Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Achim, Kless"'
Validity of the cold pressor test and pain sensitivity questionnaire via online self-administration.
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231697 (2020)
To determine the feasibility of complex home-based phenotyping, 1,876 research participants from the customer base of 23andMe completed an online version of a Pain Sensitivity Questionnaire (PSQ) as well as a cold pressor test (CPT) which is used in
Externí odkaz:
https://doaj.org/article/fd2ae13cc92f4069ab9ad0fd019e9717
Publikováno v:
Pain. 163:1763-1776
We deployed an online pain sensitivity questionnaire (PSQ) and an at-home version of the cold pressor test (CPT) in a large genotyped cohort. We performed genome-wide association studies on the PSQ score (25,321 participants) and CPT duration (6853).
Autor:
Mona L Knapp, Dalia Alansary, Vanessa Poth, Kathrin Förderer, Frederik Sommer, David Zimmer, Yvonne Schwarz, Nicolas Künzel, Achim Kless, Khaled Machaca, Volkhard Helms, Timo Mühlhaus, Michael Schroda, Annette Lis, Barbara A Niemeyer
Publikováno v:
EMBO reports. 23
Alternative splicing is a potent modifier of protein function. Stromal interaction molecule 1 (Stim1) is the essential activator of store-operated Ca
Autor:
Juan Zeng, Riccardo Guareschi, Mangesh Damre, Ruyin Cao, Achim Kless, Bernd Neumaier, Andreas Bauer, Alejandro Giorgetti, Paolo Carloni, Giulia Rossetti
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2588 (2018)
Positron emission tomography (PET) radioligands targeting the human translocator membrane protein (TSPO) are broadly used for the investigations of neuroinflammatory conditions associated with neurological disorders. Structural information on the mam
Externí odkaz:
https://doaj.org/article/519dbc030bd54fe880cb7de79f314a95
Autor:
Xiaojing Cong, Pablo Campomanes, Achim Kless, Inga Schapitz, Markus Wagener, Thomas Koch, Paolo Carloni
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135998 (2015)
Atomistic descriptions of the μ-opioid receptor (μOR) noncovalently binding with two of its prototypical morphinan agonists, morphine (MOP) and hydromorphone (HMP), are investigated using molecular dynamics (MD) simulations. Subtle differences betw
Externí odkaz:
https://doaj.org/article/07ce42f2f7d74c9eab829753267f6531
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231697 (2020)
PLoS ONE, Vol 15, Iss 4, p e0231697 (2020)
To determine the feasibility of complex home-based phenotyping, 1,876 research participants from the customer base of 23andMe participated in an online version of a Pain Sensitivity Questionnaire (PSQ) as well as a cold pressor test (CPT) which is us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7952ac1486fb77477bdf514ceb79fd7a
https://doi.org/10.1101/19011775
https://doi.org/10.1101/19011775
Altered pain sensitivity is believed to play an important role in the development of chronic pain, a common debilitating condition affecting an estimated 1 in 5 adults. Pain sensitivity varies broadly between individuals, and it is notoriously diffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a69e1f05560a0c34b4480c2a34e4bb5
https://doi.org/10.1101/837526
https://doi.org/10.1101/837526
Autor:
Astrid S. Obrecht, Günther Schmalzing, Michael Schaefer, Anni Röse, Achim Kless, Jannis E. Meents, Ralf Hausmann, Aliaa Abdelrahman, Nicole Urban, Angelika Lampert, Christa E. Müller
Publikováno v:
Neuropharmacology. 158
The homotrimeric P2X3 receptor, one of the seven members of the ATP-gated P2X receptor family, plays a crucial role in sensory neurotransmission. P2X3 receptor antagonists have been identified as promising drugs to treat chronic cough and are suggest
Publikováno v:
Biochemical Society Transactions
Medical research has identified over 500 brain disorders. Among these, there are still only very few neuropathologies whose causes are fully understood and, consequently, very few drugs whose mechanism of action is known. No FDA drug has been identif
Autor:
Alejandro Giorgetti, Bernd Neumaier, Ruyin Cao, Giulia Rossetti, Andreas Bauer, Mangesh V. Damre, Achim Kless, Riccardo Guareschi, Paolo Carloni, Juan Zeng
Publikováno v:
International Journal of Molecular Sciences
International journal of molecular sciences 19(9), 2588-(2018). doi:10.3390/ijms19092588
Volume 19
Issue 9
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2588 (2018)
International journal of molecular sciences 19(9), 2588 (2018). doi:10.3390/ijms19092588
International journal of molecular sciences 19(9), 2588-(2018). doi:10.3390/ijms19092588
Volume 19
Issue 9
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2588 (2018)
International journal of molecular sciences 19(9), 2588 (2018). doi:10.3390/ijms19092588
Positron emission tomography (PET) radioligands targeting the human translocator membrane protein (TSPO) are broadly used for the investigations of neuroinflammatory conditions associated with neurological disorders. Structural information on the mam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d3f67d1b85100906830fce24d8cb64