Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Achim, Aigner"'
Autor:
Leoni Lorenz, Tamara Zenz, Denys Oliinyk, Florian Meier-Rosar, Robert Jenke, Achim Aigner, Thomas Büch
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1080 (2024)
Histone deacetylase inhibitors (HDACi) show high antineoplastic potential in preclinical studies in various solid tumors, including gastric carcinoma; however, their use in clinical studies has not yet yielded convincing efficacies. Thus, further stu
Externí odkaz:
https://doaj.org/article/1129247439b8483c9cb26744a377bf8a
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 995 (2024)
Compared to other forms of drug administration, the use of Transdermal Drug Delivery Systems (TDDSs) offers significant advantages, including uniform drug release profiles that contribute to lower side effects and higher tolerability, avoidance of di
Externí odkaz:
https://doaj.org/article/8ace9d676840454a99558622448f856a
Autor:
Andreas Konopa, Melanie A. Meier, Miriam J. Franz, Emanuele Bernardinelli, Anna-Lena Voegele, Raja Atreya, Silvia Ribback, Stephanie Roessler, Achim Aigner, Kerstin Singer, Stephan Singer, Antonio Sarikas, Susanne Muehlich
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Myocardin-related transcription factors A and B (MRTFs) are coactivators of Serum Response Factor (SRF), which controls fundamental biological processes such as cell growth, migration, and differentiation. MRTF and SRF transcriptional activi
Externí odkaz:
https://doaj.org/article/470cbd2eb6b54616968344e265c1703a
Autor:
Elke Boxhammer, Vera Paar, Bernhard Wernly, Attila Kiss, Moritz Mirna, Achim Aigner, Eylem Acar, Simon Watzinger, Bruno K. Podesser, Roland Zauner, Verena Wally, Michael Ablinger, Matthias Hackl, Uta C. Hoppe, Michael Lichtenauer
Publikováno v:
Cells, Vol 12, Iss 19, p 2369 (2023)
(1) Background and Objective: MicroRNAs (miRs) are biomarkers for assessing the extent of cardiac remodeling after myocardial infarction (MI) and important predictors of clinical outcome in heart failure. Overexpression of miR-30d-5p appears to have
Externí odkaz:
https://doaj.org/article/3ee57e1640524b839369bfdde9eb29e5
Autor:
Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher, Daniel Wicklein
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Abstract Background Mesothelial E- and P-selectins substantially mediate the intraperitoneal spread of Pancreatic ductal adenocarcinoma (PDA) cells in xenograft models. In the absence of selectins in the host, the integrin subunit alpha-V (ITGAV, CD5
Externí odkaz:
https://doaj.org/article/74ad8fbecb82403c9e846f168a4d146c
Autor:
Maik Friedrich, Gabriele Pfeifer, Stefanie Binder, Achim Aigner, Philippe Vollmer Barbosa, Gustavo R. Makert, Jasmin Fertey, Sebastian Ulbert, Jochen Bodem, Eva-Maria König, Nina Geiger, Axel Schambach, Erik Schilling, Tilo Buschmann, Sunna Hauschildt, Ulrike Koehl, Katherina Sewald
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
In 2019, the novel highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak rapidly led to a global pandemic with more than 346 million confirmed cases worldwide, resulting in 5.5 million associated deaths (January 2022
Externí odkaz:
https://doaj.org/article/5e20b36e65524f26869b0193cc22cccf
Autor:
Michael Rode, Kolja Nenoff, Kerstin Wirkner, Katrin Horn, Andrej Teren, Ralf Regenthal, Markus Loeffler, Joachim Thiery, Achim Aigner, Janne Pott, Holger Kirsten, Markus Scholz
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266897 (2022)
BackgroundFor many drugs, mechanisms of action with regard to desired effects and/or unwanted side effects are only incompletely understood. To investigate possible pleiotropic effects and respective molecular mechanisms, we describe here a catalogue
Externí odkaz:
https://doaj.org/article/6ecbecd541b34b4086b21ffc807746f3
Autor:
Sven Wach, Madeleine Brandl, Hannes Borchardt, Katrin Weigelt, Sabine Lukat, Elke Nolte, Omar Al-Janabi, Martin Hart, Friedrich Grässer, Johannes Giedl, Rudolf Jung, Robert Stöhr, Arndt Hartmann, Verena Lieb, Sabrina Höbel, Anna Peters, Claudia Stäubert, Bernd Wullich, Helge Taubert, Achim Aigner
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 272-283 (2019)
MIR143 is pathologically downregulated and may function as a tumor suppressor in prostate cancer. Likewise, the urokinase plasminogen activator receptor (UPAR) is overexpressed in prostate carcinoma, representing a negative prognostic marker and puta
Externí odkaz:
https://doaj.org/article/d8d765c582e04b049197e5a16a0b421e
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1692 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer mortality. Considering its very poor prognosis, novel treatment options are urgently needed. MicroRNAs (miRNAs) are involved in the regulation of various physiological and pathologi
Externí odkaz:
https://doaj.org/article/a6e6359579494ee78b2be9cb9210814a
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1184 (2022)
Transdermal drug delivery systems (TDDSs) play important roles in therapy due to distinct advantages over other forms and types of drug application. While common TDDS patches mainly consist of polymeric matrices so far, inorganic carriers show numero
Externí odkaz:
https://doaj.org/article/d1dd64eed41e43008160c6d1715a3354