Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Achilles Dugaiczyk"'
Autor:
Rosaleen Gibbons, Achilles Dugaiczyk
Publikováno v:
Genome. 48:160-167
There are over a million Alu repetitive elements dispersed throughout the human genome, and a high level of Alu-sequence similarity ensures a strong propensity for unequal crossover events, some of which have lead to deleterious oncogenic rearrangeme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c866e48be75a3510a4fe76d745983890
https://doi.org/10.1139/g04-085
https://doi.org/10.1139/g04-085
Publikováno v:
Journal of Molecular Biology. 308:587-596
When viewed from the perspective of time, human genetic disorders give new insights into their etiology and evolution. Here, we have correlated a specific set of Alu repetitive DNA elements, known to be the basis of certain genetic defects, with thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c59a2cb520fca4ccd90064ac9d7d23af
https://doi.org/10.1006/jmbi.2001.4755
https://doi.org/10.1006/jmbi.2001.4755
Publikováno v:
Journal of Molecular Biology. 299:931-939
Differential gene expression lies at the heart of biology and is responsible for all developmental processes, including the growth and differentiation of cells. Perhaps even speciation could be defined as a change in differential gene expression over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c604fd4f694b44ac6e96bf2f0257311d
https://doi.org/10.1006/jmbi.2000.3795
https://doi.org/10.1006/jmbi.2000.3795
Publikováno v:
Biological Chemistry. 380:1431-1434
The albumin gene family arose in a series of duplication events which gave rise to symmetry in its structure. The four genes are tandemly linked on human chromosome 4q in the order: 5′ ALB-5′ AFP-5′ ALF-5′ DBP-centromere, and their introns di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd26dad2d933a5fa3c2d4df79da4783c
https://doi.org/10.1515/bc.1999.183
https://doi.org/10.1515/bc.1999.183
Publikováno v:
Journal of Molecular Biology. 289:861-871
Over the past 60 million years, or so, approximately one million copies of Alu DNA repeats have accumulated in the genome of primates, in what appears to be an ongoing process. We determined the phylogenetic distribution of specific Alu (and other) D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2400f491190ddb3e0a058f83796f9734
https://doi.org/10.1006/jmbi.1999.2797
https://doi.org/10.1006/jmbi.1999.2797
Publikováno v:
Journal of Molecular Evolution. 46:552-561
The serum albumin gene family is composed of four members that have arisen by a series of duplications from a common ancestor. From sequence differences between members of the gene family, we infer that a gene duplication some 580 Myr ago gave rise t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5760373b222f6fd5e2e7c6274b958f2a
https://doi.org/10.1007/pl00006336
https://doi.org/10.1007/pl00006336
Publikováno v:
Gene. 162:213-220
The chimpanzee (Pan troglodytes) alpha-fetoprotein (AFP)-encoding gene (AFP) spans 18,867 bp from the transcription start point to the polyadenylation site, and the nucleotide (nt) sequence reveals that the gene is composed of 15 exons, which are sym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7d91f247c38284f18141a79a8e6aa4
https://doi.org/10.1016/0378-1119(95)00303-n
https://doi.org/10.1016/0378-1119(95)00303-n
Autor:
Achilles Dugaiczyk, Peter E. M. Gibbs
Publikováno v:
Proceedings of the National Academy of Sciences. 91:3413-3417
The closely related serum albumin, alpha-fetoprotein, and vitamin D-binding proteins are derived from a common ancestor, which itself was the result of a triplication of an ancestral gene. We have aligned the sequences of these proteins against thems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f427d10997151ce52cfb9dc2883afe
https://doi.org/10.1073/pnas.91.8.3413
https://doi.org/10.1073/pnas.91.8.3413
Publikováno v:
Proceedings of the National Academy of Sciences. 90:1872-1876
We have identified four genetic novelties that are fixed in specific primate lineages and hence can serve as phylogenetic time markers. One Alu DNA repeat is present in the human lineage but is absent from the great apes. Another Alu DNA repeat is pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1329eaf39b7b0446743cee2b83095284
https://doi.org/10.1073/pnas.90.5.1872
https://doi.org/10.1073/pnas.90.5.1872
Autor:
Rosaleen, Gibbons, Lars J, Dugaiczyk, Thomas, Girke, Brian, Duistermars, Rita, Zielinski, Achilles, Dugaiczyk
Publikováno v:
Journal of molecular biology. 339(4)
Humans and chimpanzees share some 99% of DNA and amino acid identity, yet they exhibit important biomedical, morphological, and cognitive differences, difficult to accommodate within the remaining 1% of sequence diversity. Other types of genetic vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::301fb529951a30810a249ff675c590c8
https://pubmed.ncbi.nlm.nih.gov/15165846
https://pubmed.ncbi.nlm.nih.gov/15165846