Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Achiel Haemers"'
Autor:
Louis Maes, Jana Rudolf, Jurgen Joossens, Pieter Van der Veken, Jeremy C. Mottram, Paul Cos, Graham H. Coombs, Catherine X. Moss, Koen Augustyns, Achiel Haemers, Venkatraj Muthusamy, Maya Berg, Matthias Breugelmans
Publikováno v:
Bioorganic and medicinal chemistry letters
Metacaspase (MCA) is an important enzyme in Trypanosoma brucei, absent from humans and differing significantly from the orthologous human caspases. Therefore MCA constitutes a new attractive drug target for antiparasitic chemotherapeutics, which need
Publikováno v:
Expert opinion on therapeutic patents
Dipeptidyl peptidase IV (DPP IV) is a validated target for the treatment of Type 2 diabetes, with several inhibitors currently in Phase III clinical trials. This review will mainly focus on DPP IV inhibitors that were published in scientific literatu
Autor:
Christian V. Stevens, Ibrahim El Sayed, Jurgen Joossens, Achiel Haemers, Koen Augustyns, Pieter Van der Veken
Publikováno v:
Publons
ResearcherID
Synthesis : journal of synthetic organic chemistry
ResearcherID
Synthesis : journal of synthetic organic chemistry
Diphenyl α-aminomethylphosphonates are prepared in good yields using a Lewis acid catalyzed Birum-Oleksyszyn reaction. This approach enlarges the scope of this reaction, allowing the use of aldehydes and ketones and the use of acid-labile groups in
Publikováno v:
Tetrahedron letters
( E )- and ( Z )-fluoro-olefin analogues of potent dipeptidyl peptidase IV inhibitors were synthesized. A Wadsworth–Horner–Emmons reaction, followed by amide formation and reduction of the amide were used for the construction of the α-fluoro-α,
Autor:
Liesbeth Daniels, Achiel Haemers, Koen Augustyns, Simon Scharpé, Pieter Van der Veken, Ingrid De Meester, Kristel Senten, Anne-Marie Lambeir
Publikováno v:
Journal of Combinatorial Chemistry
In this paper, we present a parallel synthesis of several series of dipeptide diphenyl phosphonates that are known to be irreversible inhibitors of serine proteases. Polymer-assisted solution-phase synthesis (PASP) is used for the rapid and clean cou
Autor:
Geert Rombouts, Guy L. F. Lemiere, Roger Dommisse, Achiel Haemers, Luc Pieters, Tim H. M. Jonckers, Bert U. W. Maes
Publikováno v:
Synlett. :0615-0618
Isocryptolepine (cryptosanguinolentine) has been synthesized in three steps via a new approach starting from commercially available 4-chloroquinoline and 2-chloroaniline. The new methodology consists of two consecutive palladium-catalyzed reactions;
Autor:
Guy L. F. Lemiere, Kristof T. J. Loones, Roger Dommisse, Bert U. W. Maes, Tim H. M. Jonckers, Achiel Haemers
Publikováno v:
Synlett : accounts and rapid communications in synthetic organic chemistry
Regioselective palladium-catalyzed aminations with anilines on 2-chloro-3-iodo- and 2-chloro-5-iodopyridine have been performed with excellent yields and good selectivity. The use of a large excess of Cs 2 CO 3 in combination with Pd-BINAP catalyst w
Autor:
Bert U. W. Maes, Jef Rozenski, Achiel Haemers, Janez Košmrlj, Guy L. F. Lemiere, Omar R'kyek, E. L. Esmans, Roger Dommisse
Publikováno v:
Tetrahedron
The synthesis of 4-aryl-5-methoxy-, 5-aryl-4-methoxy- and 4,5-diaryl-3(2H)-pyridazinones via Suzuki palladium-catalysed cross-coupling reactions with the corresponding chloro-3(2H)-pyridazinones is described.
Publikováno v:
Journal of heterocyclic chemistry
The synthesis of N1-substituted 4-pyrimidones is described. These compounds were prepared from their corresponding 4-oxopyrimidinium perchlorates or from a reaction of a primary amine with a N-acyl-β-ketoamide.
Publikováno v:
Journal of Mass Spectrometry. 33:631-643
The effect of the metal ion on the high-energy collision-induced dissociation (CID) of alkali metal-cationized n-butyl and methyl ester derivatives of palmitic and oleic acid was examined. The results show that the alkali metal ion has a pronounced e