Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Achia Urbach"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4520 (2024)
The significant heterogeneity of Wilms’ tumors between different patients is thought to arise from genetic and epigenetic distortions that occur during various stages of fetal kidney development in a way that is poorly understood. To address this,
Externí odkaz:
https://doaj.org/article/19d6f6750c574c47bb76e40d4a803f8c
Autor:
Yishay Wineberg, Itamar Kanter, Nissim Ben-Haim, Naomi Pode-Shakked, Efrat Bucris, Tali Hana Bar-Lev, Sarit Oriel, Harel Reinus, Yishai Yehuda, Rotem Gershon, Rachel Shukrun, Dekel Dov Bar-Lev, Achia Urbach, Benjamin Dekel, Tomer Kalisky
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Nephrons are the functional units of the kidney. During kidney development, cells from the cap mesenchyme—a transient kidney-specific progenitor state—undergo a mesenchymal to epithelial transition (MET) and subsequently differentiate in
Externí odkaz:
https://doaj.org/article/e0c40f40f54d4a0192db098dd6e00014
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3532 (2023)
Wilms’ tumors are pediatric malignancies that are thought to arise from faulty kidney development. They contain a wide range of poorly differentiated cell states resembling various distorted developmental stages of the fetal kidney, and as a result
Externí odkaz:
https://doaj.org/article/6f087ecfe57f4510854bfb26377fd0e1
Autor:
Yam Ben-Haim, Leah Armon, Boris Fichtman, Irina Epshtein, Ronen Spiegel, Amnon Harel, Achia Urbach
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102539- (2021)
LAP1 is an inner nuclear membrane protein encoded by TOR1AIP1. A homozygous c.961C > T loss of function mutation in TOR1AIP1 that affects both isoforms of LAP1 was recently described. This mutation leads to the development of a severe multisystemic n
Externí odkaz:
https://doaj.org/article/1df3462861af41a4802e536d62a54806
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 8, Pp 871-881 (2018)
Wilms' tumor is a pediatric malignancy that is thought to originate from faulty kidney development during the embryonic stage. However, there is a large variation between tumors from different patients in both histology and gene expression that is no
Externí odkaz:
https://doaj.org/article/a3026384a0d84ac69cfdb2c45e8ec968
Autor:
Oren Pleniceanu, Racheli Shukrun, Dorit Omer, Einav Vax, Itamar Kanter, Klaudyna Dziedzic, Naomi Pode‐Shakked, Michal Mark‐Daniei, Sara Pri‐Chen, Yehudit Gnatek, Hadas Alfandary, Nira Varda‐Bloom, Dekel D Bar‐Lev, Naomi Bollag, Rachel Shtainfeld, Leah Armon, Achia Urbach, Tomer Kalisky, Arnon Nagler, Orit Harari‐Steinberg, Jack L Arbiser, Benjamin Dekel
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 4, Pp 508-530 (2017)
Abstract Angiomyolipoma (AML), the most common benign renal tumor, can result in severe morbidity from hemorrhage and renal failure. While mTORC1 activation is involved in its growth, mTORC1 inhibitors fail to eradicate AML, highlighting the need for
Externí odkaz:
https://doaj.org/article/04ce0232c4284454b179f5026fd0dc37
Autor:
Achia Urbach, Nissim Benvenisty
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4175 (2009)
Turner's syndrome (caused by monosomy of chromosome X) is one of the most common chromosomal abnormalities in females. Although 3% of all pregnancies start with XO embryos, 99% of these pregnancies terminate spontaneously during the first trimester.
Externí odkaz:
https://doaj.org/article/a2375b4a39074f10ac2160e516b32a9e
Publikováno v:
Stem Cell Reports
Summary Epigenetic regulation by the SWI/SNF complex is essential for normal self-renewal capacity and pluripotency of human pluripotent stem cells (hPSCs). It has been shown that different subunits of the complex have a distinct role in this regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfb82795f2c6f9a17081778264ffbf0
http://europepmc.org/articles/PMC7664050
http://europepmc.org/articles/PMC7664050
Publikováno v:
SSRN Electronic Journal.
Wilms’ tumors are pediatric malignancies that are thought to arise from faulty kidney development. To date, the course of treatment depends on manual histopathological classification which is difficult since the tumors differ between patients in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2dcab385445be6eade388db149d0cd
https://doi.org/10.2139/ssrn.4186255
https://doi.org/10.2139/ssrn.4186255
Publikováno v:
Biology of the cellREFERENCES. 113(11)
BACKGROUND INFORMATION Lin28A and its paralog Lin28B are RNA binding proteins expressed in stem and progenitor cells, regulating the balance between their proliferation and differentiation. In-vivo and in-vitro experiments have shown that overexpress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a1fc752d7878a5e32c98692743dc9b
https://pubmed.ncbi.nlm.nih.gov/34437724
https://pubmed.ncbi.nlm.nih.gov/34437724