Magnetic resonance imaging and ultrasound elastography in the context of preclinical pharmacological research: significance for the 3R principles.

Autor: Obrecht M; Diseases of Aging and Regenerative Medicines, Novartis Institutes for BioMedical Research, Basel, Switzerland., Zurbruegg S; Neurosciences Department, Novartis Institutes for BioMedical Research, Basel, Switzerland., Accart N; Diseases of Aging and Regenerative Medicines, Novartis Institutes for BioMedical Research, Basel, Switzerland., Lambert C; Diseases of Aging and Regenerative Medicines, Novartis Institutes for BioMedical Research, Basel, Switzerland., Doelemeyer A; Diseases of Aging and Regenerative Medicines, Novartis Institutes for BioMedical Research, Basel, Switzerland., Ledermann B; 3Rs Leader, Novartis Institutes for BioMedical Research, Basel, Switzerland., Beckmann N; Diseases of Aging and Regenerative Medicines, Novartis Institutes for BioMedical Research, Basel, Switzerland.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 Jun 28; Vol. 14, pp. 1177421. Date of Electronic Publication: 2023 Jun 28 (Print Publication: 2023).

Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.

Autor: Freedman BR; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Kuttler A; Novartis Institutes for Biomedical Research, Basel, Switzerland., Beckmann N; Novartis Institutes for Biomedical Research, Basel, Switzerland., Nam S; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Kent D; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Schuleit M; Novartis Institutes for Biomedical Research, Basel, Switzerland., Ramazani F; Novartis Institutes for Biomedical Research, Basel, Switzerland., Accart N; Novartis Institutes for Biomedical Research, Basel, Switzerland., Rock A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Li J; Department of Mechanical Engineering, McGill University, Montreal, Quebec, Canada., Kurz M; Novartis Institutes for Biomedical Research, Basel, Switzerland., Fisch A; Novartis Institutes for Biomedical Research, Basel, Switzerland., Ullrich T; Novartis Institutes for Biomedical Research, Basel, Switzerland., Hast MW; Biedermann Lab for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA., Tinguely Y; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Weber E; Novartis Institutes for Biomedical Research, Basel, Switzerland. eckhard.weber@novartis.com., Mooney DJ; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. mooneyd@seas.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. mooneyd@seas.harvard.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2022 Oct; Vol. 6 (10), pp. 1167-1179. Date of Electronic Publication: 2022 Jan 03.

Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses.

Autor: Alave Reyes-Furrer A; Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland., De Andrade S; Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland.; 3D Tissues and Biofabrication, Institute of Chemistry and Biotechnology (ICBT), Zurich University of Applied Sciences, Waedenswil, Switzerland., Bachmann D; Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland., Jeker H; Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland., Steinmann M; Analytical Sciences & Imaging, Novartis Institutes for BioMedical Research, Basel, Switzerland., Accart N; Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland., Dunbar A; Analytical Sciences & Imaging, Novartis Institutes for BioMedical Research, Basel, Switzerland., Rausch M; Analytical Sciences & Imaging, Novartis Institutes for BioMedical Research, Basel, Switzerland., Bono E; 3D Tissues and Biofabrication, Institute of Chemistry and Biotechnology (ICBT), Zurich University of Applied Sciences, Waedenswil, Switzerland.; Competence Center TEDD, Institute of Chemistry and Biotechnology (ICBT), Zurich University of Applied Sciences, Waedenswil, Switzerland., Rimann M; 3D Tissues and Biofabrication, Institute of Chemistry and Biotechnology (ICBT), Zurich University of Applied Sciences, Waedenswil, Switzerland. markus.rimann@zhaw.ch.; Competence Center TEDD, Institute of Chemistry and Biotechnology (ICBT), Zurich University of Applied Sciences, Waedenswil, Switzerland. markus.rimann@zhaw.ch., Keller H; Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland. hansjoerg.keller@novartis.com.

Publikováno v: Communications biology [Commun Biol] 2021 Oct 14; Vol. 4 (1), pp. 1183. Date of Electronic Publication: 2021 Oct 14.

Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues.

Autor: Mierke, Claudia Tanja¹ (AUTHOR) claudia.mierke@uni-leipzig.de

Publikováno v: Cells (2073-4409). Oct2024, Vol. 13 Issue 19, p1638. 86p.

Contrast enhanced longitudinal changes observed in an experimental bleomycin-induced lung fibrosis rat model by radial DCE-MRI at 9.4T.

Autor: in 't Zandt, René¹ (AUTHOR) rene.in_t_zandt@med.lu.se, Mahmutovic Persson, Irma^1,2 (AUTHOR), Tibiletti, Marta³ (AUTHOR), von Wachenfeldt, Karin⁴ (AUTHOR), Parker, Geoff J. M.^3,5 (AUTHOR), Olsson, Lars E.^2,6 (AUTHOR)

Publikováno v: PLoS ONE. 9/27/2024, Vol. 19 Issue 9, p1-15. 15p.