Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Acat1"'
Autor:
Qinghua Wang, Tingting Du, Zhihui Zhang, Qingyang Zhang, Jie Zhang, Wenbin Li, Jian-Dong Jiang, Xiaoguang Chen, Hai-Yu Hu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4431-4442 (2024)
Chlorogenic acid (CGA) is a natural product that effectively inhibits tumor growth, demonstrated in many preclinical models, and phase II clinical trials for patients with glioma. However, its direct proteomic targets and anticancer molecular mechani
Externí odkaz:
https://doaj.org/article/8247d7f9a4954166ba1c01e28325080e
Publikováno v:
The Clinical Respiratory Journal, Vol 18, Iss 10, Pp n/a-n/a (2024)
ABSTRACT Background Lung cancer, on a global scale, leads to the most common cases of cancer mortalities. Novel therapeutic approaches are urgently needed to disrupt this lethal disease. The rapid development of tumor immunology combining breakthroug
Externí odkaz:
https://doaj.org/article/34e44415d3be4b13967c60fae5b79106
Akademický článek
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Autor:
Wei He, Yanfang Li, Song-Bai Liu, Ying Chang, Shiyuan Han, Xingyu Han, Zixin Ma, Hesham M. Amin, Yao-Hua Song, Jin Zhou
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Acetyl CoA acetyltransferase 1 (ACAT1), a mitochondrial enzyme, is mainly involved in the formation and decomposition of ketones, isoleucine, and fatty acids. Previous clinical studies showed that mutations in the ACAT1 gene lead to ketoacidosis, Not
Externí odkaz:
https://doaj.org/article/1f9a994c0cab4d3da4cfeb64d6394a46
Autor:
Syed A. H. Zaidi, Tahira Lemtalsi, Zhimin Xu, Isabella Santana, Porsche Sandow, Leila Labazi, Robert W. Caldwell, Ruth B. Caldwell, Modesto A. Rojas
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background We have investigated the efficacy of a new strategy to limit pathological retinal neovascularization (RNV) during ischemic retinopathy by targeting the cholesterol metabolizing enzyme acyl-coenzyme A: cholesterol transferase 1 (AC
Externí odkaz:
https://doaj.org/article/244c1151a5824f26b7731f1f299bdc78
Autor:
Jingqian Guan, Xizi Jiang, Yaoxing Guo, Wenhui Zhao, Ji Li, Yizhuo Li, Ming Cheng, Lin Fu, Yue Zhao, Qingchang Li
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Prostate cancer is a major health issue affecting the male population worldwide, and its etiology remains relatively unknown. As presented on the Gene Expression Profiling Interactive Analysis database, acetyl-CoA acetyltransferas
Externí odkaz:
https://doaj.org/article/ac449d02b7754283844851d4d434765e
Autor:
Qiong Su, Jie Yao, Muhammad Asad Farooq, Iqra Ajmal, Yixin Duan, Cong He, Xuefei Hu, Wenzheng Jiang
Publikováno v:
Cells, Vol 13, Iss 6, p 555 (2024)
CD19-specific CAR-T immunotherapy has been extensively studied for the treatment of B-cell lymphoma. Recently, cholesterol metabolism has emerged as a modulator of T lymphocyte function and can be exploited in immunotherapy to increase the efficacy o
Externí odkaz:
https://doaj.org/article/7615062fc2944322a30aec06d00fc84d
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Vijayalakshmi Ayyagari, Maio Li, Zvi Pasman, Xinjia Wang, Somaja Louis, Paula Diaz-Sylvester, Kathleen Groesch, Teresa Wilson, Laurent Brard
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Abnormal accumulation of acyl-CoA cholesterol acyltransferase-1 (ACAT1) and ACAT1-mediated cholesterol esterified with fatty acids (CE) contribute to cancer progression in various cancers. Our findings of increased CE and ACAT1 le
Externí odkaz:
https://doaj.org/article/6bf523f619c84a648fe32dd3716b6c43