Výsledky vyhledávání - "AcademicSubjects/MED00994"

Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology

Autor: Erik N. Uhlmann, Rafael A Vega, Matthew P. Anderson, Hemant Varma, Martina Stippler, Justin M. Moore, Ron L. Alterman, Rosalia Rabinovsky, Rachid El Fatimy, Anna M. Krichevsky, Ajith J. Thomas, Franciela C Kipper, Ekkehard M. Kasper, Erik J. Uhlmann

Publikováno v: Journal of Neuropathology and Experimental Neurology

Meningioma is the most common primary central nervous system tumor. Although mostly nonmalignant, meningioma can cause serious complications by mass effect and vasogenic edema. While surgery and radiation improve outcomes, not all cases can be treate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8be1d485ecac5ffdcbb9706995e5980
http://europepmc.org/articles/PMC8716066

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Multiple Sclerosis: Microglia, Monocytes, and Macrophage-Mediated Demyelination

Autor: John W. Prineas, John Parratt

Publikováno v: Journal of Neuropathology and Experimental Neurology

This study examined the roles of microglia and monocytes in myelin destruction in patients with early multiple sclerosis (MS). Twenty-two cases were studied; the clinical duration was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b0bf89074c01a20709e8b33ea8b653
https://doi.org/10.1093/jnen/nlab083

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Fast Progression in Amyotrophic Lateral Sclerosis Is Associated With Greater TDP-43 Burden in Spinal Cord

Autor: Leif E. Peterson, Matthew D. Cykowski, Anithachristy S. Arumanayagam, Stanley H. Appel, Sahara J. Cathcart, Ericka P Greene, Suzanne Zein-Eldin Powell, Andreana L. Rivera

Publikováno v: Journal of Neuropathology and Experimental Neurology

Upper and lower motor neuron pathologies are critical to the autopsy diagnosis of amyotrophic lateral sclerosis (ALS). Further investigation is needed to determine how the relative burden of these pathologies affects the disease course. We performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609b3cdf867e13c37436f24bf53b4ffa
https://doi.org/10.1093/jnen/nlab061

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Silencing of lncRNA XLOC_035088 Protects Middle Cerebral Artery Occlusion-Induced Ischemic Stroke by Notch1 Signaling

Autor: Feng Wang, Hairong Wang, Miao Chen

Publikováno v: Journal of Neuropathology and Experimental Neurology

Ischemic stroke represents one of the leading causes of mortality worldwide and especially in developing countries. It is crucial for finding effective therapeutic targets that protect the brain against ischemic injury. Long noncoding RNAs (lncRNAs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ce368fb9d2317eb3587f176592dea2
http://europepmc.org/articles/PMC7749712

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Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

Publikováno v: Journal of Neuropathology and Experimental Neurology
Journal of neuropathology and experimental neurology 79(11), 1141-1146 (2020). doi:10.1093/jnen/nlaa109

Recent studies in animal models demonstrate that certain misfolded proteins associated with neurodegenerative diseases can support templated misfolding of cognate native proteins, to propagate across neural systems, and to therefore have some of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b04ff8d370b02ea54af1da56b42d2b7
http://europepmc.org/articles/PMC7577514

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Myelin Pathology Beyond White Matter in Tuberous Sclerosis Complex (TSC) Cortical Tubers

Publikováno v: Journal of Neuropathology and Experimental Neurology
Journal of neuropathology and experimental neurology, 79(10), 1054-1064. Lippincott Williams and Wilkins

Tuberous sclerosis complex (TSC) is a monogenetic disease that arises due to mutations in either the TSC1 or TSC2 gene and affects multiple organ systems. One of the hallmark manifestations of TSC are cortical malformations referred to as cortical tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d390b19cacf18a83c8b00da56c397d
http://europepmc.org/articles/PMC7559237

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Cobblestone Malformation in LAMA2 Congenital Muscular Dystrophy (MDC1A)

Autor: William B. Dobyns, John W. Day, Kelly Chen, Steven A. Moore, Joline C. Dalton, Arti Pandya, Louanne Hudgins, Sanam Zarei, Kara A. Withrow, Himali Jayakody, Huy Nguyen, Katherine D. Mathews, Jean Teasley

Publikováno v: Journal of Neuropathology and Experimental Neurology

Congenital muscular dystrophy type 1A (MDC1A) is caused by recessive variants in laminin α2 (LAMA2). Patients have been found to have white matter signal abnormalities on magnetic resonance imaging (MRI) but rarely structural brain abnormalities. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c0fe919030cdfef803df3a69b6e516
https://doi.org/10.1093/jnen/nlaa062

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