Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Abuzar Kaleem"'
Autor:
Megan C. Baird, Shibi B. Likhite, Tatyana A. Vetter, Joseph R. Caporale, Holly B. Girard, Florence S. Roussel, Abigail E. Howard, Maura K. Schwartz, Addison R. Reed, Abuzar Kaleem, Xiaojin Zhang, Kathrin C. Meyer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101312- (2024)
Neuroinflammation is a miscreant in accelerating progression of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). However, treatments targeting neuroinflammation alone have led to disappointing results in clinical trials
Externí odkaz:
https://doaj.org/article/e03e2e54945a4ebb95e805af30019e49
Autor:
Julieth Andrea Sierra-Delgado, Shrestha Sinha-Ray, Abuzar Kaleem, Meysam Ganjibakhsh, Mohini Parvate, Samantha Powers, Xiaojin Zhang, Shibi Likhite, Kathrin Meyer
Publikováno v:
Biology, Vol 12, Iss 6, p 867 (2023)
Spinal Muscular Atrophy (SMA) is the leading genetic cause of infant mortality. The most common form of SMA is caused by mutations in the SMN1 gene, located on 5q (SMA). On the other hand, mutations in IGHMBP2 lead to a large disease spectrum with no
Externí odkaz:
https://doaj.org/article/ec1568725af94887919d4c560a42e448
Publikováno v:
International Journal Bioautomation, Vol 14, Iss 4, Pp 233-246 (2010)
Transient Receptor Potential-Canonical (TRPC) channels are the border guards residing in the supra-molecular assembly of plasma membrane. TRPCs represent a family of channels that have dual functions of store-operated and second messenger-operated ch
Externí odkaz:
https://doaj.org/article/03356231f97d4f3d94f7af8b8adb0dd8
Autor:
Meyer, Julieth Andrea Sierra-Delgado, Shrestha Sinha-Ray, Abuzar Kaleem, Meysam Ganjibakhsh, Mohini Parvate, Samantha Powers, Xiaojin Zhang, Shibi Likhite, Kathrin
Publikováno v:
Biology; Volume 12; Issue 6; Pages: 867
Spinal Muscular Atrophy (SMA) is the leading genetic cause of infant mortality. The most common form of SMA is caused by mutations in the SMN1 gene, located on 5q (SMA). On the other hand, mutations in IGHMBP2 lead to a large disease spectrum with no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::e888584db61bc830532b9de52b2f41e5
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity
Autor:
Emily L. Relton, Nicolas J. Roth, Seda Yasa, Abuzar Kaleem, Guido Hermey, Christopher J. Minnis, Sara E. Mole, Tatyana Shelkovnikova, Stephane Lefrancois, Peter J. McCormick, Nicolas Locker
Publikováno v:
Journal of Biological Chemistry. 299:104649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3ebac2b96625591a4a42035c785b922
https://doi.org/10.1016/j.jbc.2023.104649
https://doi.org/10.1016/j.jbc.2023.104649
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity
Autor:
Emily L. Relton, Nicolas J. Roth, Seda Yasa, Abuzar Kaleem, Guido Hermey, Stephane Lefrancois, Peter J. McCormick, Nicolas Locker
The assembly of membrane-less organelles such as stress granules (SGs) is emerging as central in helping cells rapidly respond and adapt to stress. Following stress sensing, the resulting global translational shutoff leads to the condensation of stal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed33682083daa19d7d22202b97fee15
https://doi.org/10.1101/2022.05.20.492784
https://doi.org/10.1101/2022.05.20.492784
Autor:
Marcel Klein, Abuzar Kaleem, Sandra Oetjen, Daniela Wünkhaus, Lars Binkle, Sandra Schilling, Milena Gjorgjieva, Ralf Scholz, Doris Gruber-Schoffnegger, Stephan Storch, Stefan Kins, Gerard Drewes, Sabine Hoffmeister-Ullerich, Dietmar Kuhl, Guido Hermey
Publikováno v:
Autophagy. 18(9)
PSENEN/PEN2 is the smallest subunit of the γ-secretase complex, an intramembrane protease that cleaves proteins within their transmembrane domains. Mutations in components of the γ-secretase underlie familial Alzheimer disease. In addition to its p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fe3c4fe2dcef4110346d20f2bf3b9b
https://pubmed.ncbi.nlm.nih.gov/34964690
https://pubmed.ncbi.nlm.nih.gov/34964690
Autor:
Guido Hermey, Graziana Modica, Abuzar Kaleem, Etienne Sauvageau, Seda Yasa, Stephane Lefrancois
Publikováno v:
Journal of Cell Science.
Mutations in CLN3 are a cause of juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease. Clinical manifestations include cognitive regression, progressive loss of vision and motor function, epileptic seizures and a significantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c859944f455940a50786ef9ed7dd70de
https://doi.org/10.1242/jcs.234047
https://doi.org/10.1242/jcs.234047
Autor:
Abuzar Kaleem, Seda Yasa, Etienne Sauvageau, Stephane Lefrancois, Guido Hermey, Graziana Modica
Mutations in CLN3 are a cause of juvenile NCL (JNCL), also known as Batten Disease. Clinical manifestations includes cognitive regression, progressive loss of vision and motor function, epileptic seizures, and a significantly reduced lifespan. CLN3 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb491f5471c6c922c8074a559765475c
https://doi.org/10.1101/634915
https://doi.org/10.1101/634915