Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.

Autor: Williams WB; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA. Electronic address: wilton.williams@duke.edu., Meyerhoff RR; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA., Edwards RJ; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA., Li H; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Manne K; Duke Human Vaccine Institute, Durham, NC 27710, USA., Nicely NI; Duke Human Vaccine Institute, Durham, NC 27710, USA., Henderson R; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA., Zhou Y; Department of Computer Science, Duke University, Durham, NC 27708, USA., Janowska K; Duke Human Vaccine Institute, Durham, NC 27710, USA., Mansouri K; Duke Human Vaccine Institute, Durham, NC 27710, USA., Gobeil S; Duke Human Vaccine Institute, Durham, NC 27710, USA., Evangelous T; Duke Human Vaccine Institute, Durham, NC 27710, USA., Hora B; Duke Human Vaccine Institute, Durham, NC 27710, USA., Berry M; Duke Human Vaccine Institute, Durham, NC 27710, USA., Abuahmad AY; Duke Human Vaccine Institute, Durham, NC 27710, USA., Sprenz J; Duke Human Vaccine Institute, Durham, NC 27710, USA., Deyton M; Duke Human Vaccine Institute, Durham, NC 27710, USA., Stalls V; Duke Human Vaccine Institute, Durham, NC 27710, USA., Kopp M; Duke Human Vaccine Institute, Durham, NC 27710, USA., Hsu AL; Genome Integrity and Structural Biology Laboratory, NIEHS, NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Borgnia MJ; Genome Integrity and Structural Biology Laboratory, NIEHS, NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Stewart-Jones GBE; Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA., Lee MS; Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Bronkema N; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA., Moody MA; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Immunology, Duke University, Durham, NC 27710, USA; Department of Pediatrics, Duke University, Durham, NC 27710, USA., Wiehe K; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA., Bradley T; Duke Human Vaccine Institute, Durham, NC 27710, USA., Alam SM; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA., Parks RJ; Duke Human Vaccine Institute, Durham, NC 27710, USA., Foulger A; Duke Human Vaccine Institute, Durham, NC 27710, USA., Oguin T; Duke Human Vaccine Institute, Durham, NC 27710, USA., Sempowski GD; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA., Bonsignori M; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA., LaBranche CC; Department of Surgery, Duke University, Durham, NC 27710, USA., Montefiori DC; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Surgery, Duke University, Durham, NC 27710, USA., Seaman M; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA., Santra S; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA., Perfect J; Department of Medicine, Duke University, Durham, NC 27710, USA., Francica JR; Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA., Lynn GM; Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA; Avidea Technologies, Inc., Baltimore, MD, USA., Aussedat B; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Walkowicz WE; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Laga R; Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic., Kelsoe G; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Immunology, Duke University, Durham, NC 27710, USA., Saunders KO; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Immunology, Duke University, Durham, NC 27710, USA; Department of Surgery, Duke University, Durham, NC 27710, USA., Fera D; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA., Kwong PD; Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA., Seder RA; Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA., Bartesaghi A; Department of Computer Science, Duke University, Durham, NC 27708, USA; Department of Biochemistry, Duke University, Durham, NC 27705, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA., Shaw GM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Acharya P; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Surgery, Duke University, Durham, NC 27710, USA. Electronic address: priyamvada.acharya@duke.edu., Haynes BF; Duke Human Vaccine Institute, Durham, NC 27710, USA; Department of Medicine, Duke University, Durham, NC 27710, USA; Department of Immunology, Duke University, Durham, NC 27710, USA. Electronic address: hayne002@mc.duke.edu.

Publikováno v: Cell [Cell] 2021 May 27; Vol. 184 (11), pp. 2955-2972.e25. Date of Electronic Publication: 2021 May 20.