Enhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications.

Autor: Davis E; The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Avniel-Polak S; The Neuroendocrine Tumor Unit, European Neuroendocrine Tumor Society Center of Excellence, Division of Internal Medicine, Hadassah Medical Center, Jerusalem 9112102, Israel., Abu-Kamel S; The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Antman I; The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Saadoun T; The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Brim C; The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Jumaa M; Department of Pathology, Hadassah Medical Center, Jerusalem 9112102, Israel., Maron Y; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Maimon O; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.; Department of Oncology, Hadassah Medical Center, Jerusalem 9112102, Israel., Bel-Ange A; The Neuroendocrine Tumor Unit, European Neuroendocrine Tumor Society Center of Excellence, Division of Internal Medicine, Hadassah Medical Center, Jerusalem 9112102, Israel., Atlan K; Department of Pathology, Hadassah Medical Center, Jerusalem 9112102, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Tzur T; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.; Department of Plastic and Reconstructive Surgery, Hadassah Medical Center, Jerusalem 9112102, Israel., Abu Akar F; The Edith Wolfson Medical Center, Holon 5822012, Israel.; Department of General Surgery, Faculty of Medicine, Al-Quds University, East Jerusalem, Palestinian Territories.; Department of Thoracic Surgery, Affiliated to the Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel., Wald O; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.; Department of General Surgery, Faculty of Medicine, Al-Quds University, East Jerusalem, Palestinian Territories., Izhar U; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.; Department of General Surgery, Faculty of Medicine, Al-Quds University, East Jerusalem, Palestinian Territories., Hecht M; The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Grozinsky-Glasberg S; The Neuroendocrine Tumor Unit, European Neuroendocrine Tumor Society Center of Excellence, Division of Internal Medicine, Hadassah Medical Center, Jerusalem 9112102, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Drier Y; The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 08; Vol. 121 (41), pp. e2405001121. Date of Electronic Publication: 2024 Oct 03.

Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid.

Autor: Domingo-Sabugo C; National Heart and Lung Institute, Imperial College London, London, UK., Willis-Owen SA; National Heart and Lung Institute, Imperial College London, London, UK., Mandal A; National Heart and Lung Institute, Imperial College London, London, UK., Nastase A; National Heart and Lung Institute, Imperial College London, London, UK., Dwyer S; National Heart and Lung Institute, Imperial College London, London, UK., Brambilla C; National Heart and Lung Institute, Imperial College London, London, UK.; Department of Histopathology, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., Gálvez JH; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montréal, QC, Canada., Zhuang Q; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montréal, QC, Canada., Popat S; Royal Marsden Hospital NHS Foundation Trust, London and Surrey, UK.; The Institute of Cancer Research, London, UK., Eveleigh R; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montréal, QC, Canada., Munter M; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montréal, QC, Canada., Lim E; Department of Thoracic Surgery, Royal Brompton Hospital, London, UK., Nicholson AG; National Heart and Lung Institute, Imperial College London, London, UK.; Department of Histopathology, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., Lathrop GM; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, Montréal, QC, Canada., Cookson WO; National Heart and Lung Institute, Imperial College London, London, UK., Moffatt MF; National Heart and Lung Institute, Imperial College London, London, UK.

Publikováno v: The Journal of pathology [J Pathol] 2024 Nov; Vol. 264 (3), pp. 332-343. Date of Electronic Publication: 2024 Sep 27.

Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation.

Autor: Xia, Lei, Komissarova, Anastasia, Jacover, Arielle, Shovman, Yehuda, Arcila-Barrera, Sebastian, Tornovsky-Babeay, Sharona, Jaya Prakashan, Milsee Mol, Nasereddin, Abdelmajeed, Plaschkes, Inbar, Nevo, Yuval, Shiff, Idit, Yosefov-Levi, Oshri, Izhiman, Tamara, Medvedev, Eleonora, Eilon, Elad, Wilensky, Asaf, Yona, Simon, Parnas, Oren

Publikováno v: Nature Communications; 10/9/2023, Vol. 14 Issue 1, p1-19, 19p