Non-small cell lung cancer sensitisation to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors.

Autor: Gamal H; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Ismail KA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.; Faculty of Pharmacy, Alamein International University (AIU), Alamein City, Egypt., Omar AME; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Teleb M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Abu-Serie MM; Department of Medical Biotechnology, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Egypt., Huang S; Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada., Abdelsattar AS; Center for Microbiology and Phage Therapy, Zewail City of Sciences and Technology, October Gardens, Giza, Egypt., Zamponi GW; Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada., Fahmy H; Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, South Dakota State University, Brookings, SD, USA.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2388209. Date of Electronic Publication: 2024 Aug 14.

Superior cuproptotic efficacy of diethyldithiocarbamate-Cu 4 O 3 nanoparticles over diethyldithiocarbamate-Cu 2 O nanoparticles in metastatic hepatocellular carcinoma.

Autor: Abu-Serie MM; Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt., Barakat A; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Ramadan S; Chemistry Department, Michigan State University, East Lansing, MI, United States.; Department of Chemistry, Benha University, Benha, Egypt., Habashy NH; Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jul 15; Vol. 15, pp. 1388038. Date of Electronic Publication: 2024 Jul 15 (Print Publication: 2024).

Exploiting spirooxindoles for dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy; synthesis, evaluation, and molecular modelling studies.

Autor: Islam MS; Department of Chemistry, College of Science, King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia mislam@ksu.edu.sa refaahaljassas@gmail.com amajid@ksu.edu.sa mayyaf@ksu.edu.sa ambarakat@ksu.edu.sa., Al-Jassas RM; Department of Chemistry, College of Science, King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia mislam@ksu.edu.sa refaahaljassas@gmail.com amajid@ksu.edu.sa mayyaf@ksu.edu.sa ambarakat@ksu.edu.sa., Al-Majid AM; Department of Chemistry, College of Science, King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia mislam@ksu.edu.sa refaahaljassas@gmail.com amajid@ksu.edu.sa mayyaf@ksu.edu.sa ambarakat@ksu.edu.sa., Haukka M; Department of Chemistry, University of Jyväskylä P.O. Box 35 FI-40014 Jyväskylä Finland matti.o.haukka@jyu.fi., Nafie MS; Department of Chemistry, College of Sciences, University of Sharjah Sharjah (P.O. Box 27272) United Arab Emirates mohamed.ElSayed@sharjah.ac.ae.; Chemistry Department, Faculty of Science, Suez Canal University Ismailia 41522 Egypt mohamed_nafie@science.suez.edu.eg., Abu-Serie MM; Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City) Egypt marwaelhedaia@gmail.com., Teleb M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University Alexandria 21521 Egypt mohamed.t.ismail@alexu.edu.eg marwa.mamdouh@alexu.edu.eg., El-Yazbi A; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University Alexandria Egypt elyazbiamira@gmail.com., Alayyaf AMA; Department of Chemistry, College of Science, King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia mislam@ksu.edu.sa refaahaljassas@gmail.com amajid@ksu.edu.sa mayyaf@ksu.edu.sa ambarakat@ksu.edu.sa., Barakat A; Department of Chemistry, College of Science, King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia mislam@ksu.edu.sa refaahaljassas@gmail.com amajid@ksu.edu.sa mayyaf@ksu.edu.sa ambarakat@ksu.edu.sa., Shaaban MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University Alexandria 21521 Egypt mohamed.t.ismail@alexu.edu.eg marwa.mamdouh@alexu.edu.eg.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2024 Jul 11; Vol. 15 (8), pp. 2937-2958. Date of Electronic Publication: 2024 Jul 11 (Print Publication: 2024).

Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation.

Autor: Shaban NZ; Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt. Electronic address: nshaban2001@yahoo.co.uk., Hegazy WA; Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt. Electronic address: walaa_hegazy@alexu.edu.eg., Abu-Serie MM; Department of Medical Biotechnology, Genetic Engineering, and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg EL-Arab, Alexandria 21934, Egypt., Talaat IM; Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; Clinical Sciences Department, College of Medicine, University of Sharjah, United Arab Emirates. Electronic address: iman_talaat@yahoo.com., Awad OM; Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt. Electronic address: olfatmoheyeldin1@gmail.com., Habashy NH; Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Jun; Vol. 175, pp. 116638. Date of Electronic Publication: 2024 Apr 29.

Design and Synthesis of Quinoxaline Hybrids as Modulators of HIF-1a, VEGF, and p21 for Halting Colorectal Cancer.

Autor: Ayoup MS; Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria 21321, Egypt., Rabee AR; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria 21321, Egypt., Abdel-Hamid H; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria 21321, Egypt., Amer A; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria 21321, Egypt., Abu-Serie MM; Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El Arab, Alexandria 21934, Egypt., Ashraf S; Bio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, 21511 Alexandria, Egypt., Ghareeb DA; Bio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, 21511 Alexandria, Egypt.; Center of Excellence for Drug Preclinical Studies (CE-DPS), Pharmaceutical and Fermentation Industry Development Center, City of Scientific Research & Technological Applications (SRTA-city), New Borg El Arab, Alexandria 21934, Egypt., Ibrahim RS; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt., Hawsawi MB; Department of Chemistry, Faculty of Science, Umm Al-Qura University, Al Taif Road, Makkah 24382, Saudi Arabia., Negm A; Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.; Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt., Ismail MMF; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.

Publikováno v: ACS omega [ACS Omega] 2024 May 29; Vol. 9 (23), pp. 24643-24653. Date of Electronic Publication: 2024 May 29 (Print Publication: 2024).