Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Absorn Sriratana"'
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean, Christina A. Mitchell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endoso
Externí odkaz:
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Autor:
Sandra J Feeney, Meagan J McGrath, Absorn Sriratana, Stefan M Gehrig, Gordon S Lynch, Colleen E D'Arcy, John T Price, Catriona A McLean, Rossella Tupler, Christina A Mitchell
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117665 (2015)
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease with no effective treatment. The genetic cause of FSHD is complex and the primary pathogenic insult underlying the muscle disease is unknown. Several disease candidate gen
Externí odkaz:
https://doaj.org/article/07bab8db7cf243d98f24598e7f2f1235
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Matthew J. Eramo, Helen E. Abud, Lisa M Ooms, Samuel J. Rodgers, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie K. Rynkiewicz, Absorn Sriratana, Georg Ramm, Genevieve Kerr, Catriona McLean, Viola Oorschot, Ralf B. Schittenhelm, Sherene Loi, Andrew M. Ellisdon, Rajendra Gurung, Christina Anne Mitchell, Clare G Fedele, Antonella Papa, Roger J. Daly, Franco Caramia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e2bc82108595261d2a16543c76a05
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Autor:
Sandra J Feeney, Sonia Raveena Lourdes, Catriona McLean, Stefan M. Gehrig, Gordon S. Lynch, Michael Lazarou, Christina Anne Mitchell, Absorn Sriratana, Matthew J. Eramo, Rajendra Gurung, Meagan Jane Mcgrath, Frank Koentgen
Publikováno v:
Autophagy
The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic lysosome reformation (ALR), a lysosome recycling pathway, in muscle. INPP5K hydrolyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14704e97659121574b8375cc7a48168
https://doi.org/10.1172/jci135124
https://doi.org/10.1172/jci135124
Autor:
Monica J. Naughtin, Malene R. Jepsen, Sandra J. Feeney, Ross L. Coppel, David A. Sheffield, Christina Anne Mitchell, Jennifer M. Dyson, Absorn Sriratana, Micka C. Bertucci
Publikováno v:
J Biol Chem
Macrophage phagocytosis is required for effective clearance of invading bacteria and other microbes. Coordinated phosphoinositide signaling is critical both for phagocytic particle engulfment and subsequent phagosomal maturation to a degradative orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dfb6b2e9ab207e9dce88027ab1aab0
https://pubmed.ncbi.nlm.nih.gov/31543504
https://pubmed.ncbi.nlm.nih.gov/31543504
Autor:
Jennifer M Dyson, Absorn Sriratana, Monica N. Koenig, Sharon D. Ricardo, Sandra Hakim, Robin M. Hobbs, Ian M. Smyth, Elizabeth M Davies, Sandra J Feeney, Christina Anne Mitchell, Olga V. Plotnikova
Publikováno v:
Human Molecular Genetics. 25:2295-2313
Polycystic kidney disease (PKD) is a common cause of renal failure with few effective treatments. INPP5E is an inositol polyphosphate 5-phosphatase that dephosphorylates phosphoinositide 3-kinase (PI3K)-generated PI(3,4,5)P3 and is mutated in ciliopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f664b682f0537b256ba2895e14f97a15
https://doi.org/10.1093/hmg/ddw097
https://doi.org/10.1093/hmg/ddw097
Autor:
Gordon S. Lynch, Absorn Sriratana, M. Eramo, Stefan M. Gehrig, R. Gurung, Sandra J Feeney, Meagan Jane Mcgrath, Christina Anne Mitchell, M. Lazarou, Catriona McLean
Publikováno v:
Neuromuscular Disorders. 29:S126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e850394fceba2e7a49d5b3a9e26a4acd
https://doi.org/10.1016/j.nmd.2019.06.319
https://doi.org/10.1016/j.nmd.2019.06.319
Autor:
Parvin Rahman, Absorn Sriratana, Rajendra Gurung, Hidetoshi Takada, Fenny Wiradjaja, Jennifer M Dyson, Richard D Huysmans, Meredith J. Layton, David A. Sheffield, Christina Anne Mitchell, Lisa M Ooms, Tony Tiganis
Publikováno v:
Journal of Biological Chemistry. 286:29758-29770
Phosphoinositide 3-kinase (PI3K) regulates cell polarity and migration by generating phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) at the leading edge of migrating cells. The serine-threonine protein kinase Akt binds to PI(3,4,5)P(3), resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d0c1c111d69d5a34414a0c91929129
https://doi.org/10.1074/jbc.m111.263103
https://doi.org/10.1074/jbc.m111.263103
Autor:
Rajendra Gurung, Kristy A. Horan, Alex J. Fulcher, Absorn Sriratana, Carol Wicking, Georg Ramm, Tia DiTommaso, Sandra Hakim, Ian M. Smyth, Sarah E Conduit, Sandra J Feeney, Christina Anne Mitchell, Jennifer M Dyson
Publikováno v:
The Journal of Cell Biology
Dyson et al. demonstrate that the inositol polyphosphate 5-phosphatase INPP5E is essential for Hedgehog-dependent embryonic development. By regulating PI(4,5)P2 and PI(3,4,5)P3 signals at cilia, INPP5E contributes to cilia transition zone function an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6132dcd0e1a60df9b4fbdfa3d17f553
https://pubmed.ncbi.nlm.nih.gov/27998989
https://pubmed.ncbi.nlm.nih.gov/27998989
Autor:
Absorn Sriratana, Christina Anne Mitchell, Stefan M. Gehrig, Colleen Elizabeth D'Arcy, Gordon S. Lynch, Meagan Jane Mcgrath, Sandra J Feeney, Catriona McLean, Rossella Tupler, John T. Price
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 2, p e0117665 (2015)
PLoS ONE, Vol 10, Iss 2, p e0117665 (2015)
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease with no effective treatment. The genetic cause of FSHD is complex and the primary pathogenic insult underlying the muscle disease is unknown. Several disease candidate gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972362df3395f9a9c97edf79ad832872
http://europepmc.org/articles/PMC4335040
http://europepmc.org/articles/PMC4335040