Zobrazeno 1 - 10
of 2 600
pro vyhledávání: '"Abscopal effect"'
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Radiotherapy (RT) controls local lesions, meantime it has the capability to induce systemic response to inhibit distant, metastatic, non-radiated tumors, which is referred to as the “abscopal effect”. It is widely recognized that radioth
Externí odkaz:
https://doaj.org/article/aa020035844b4b7bb900c1f4e3ad339c
Autor:
Vishali Moond, Bhumi Maniyar, Prateek Suresh Harne, Jennifer M. Bailey-Lundberg, Nirav C. Thosani
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 5, Pp 1056-1073 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognostics and substantial therapeutic challenges, with dismal survival rates. Tumor resistance in PDAC is primarily attributed to its fibrotic, hypoxic, and immune-suppressive tumor m
Externí odkaz:
https://doaj.org/article/af71d80df71c4d0aa68cc789a7429f23
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The combination of immune checkpoint inhibitors with radiotherapy can enhance the immunomodulation by RT and reduce the growth of distant unirradiated tumors (abscopal effect); however, the results are still not very satisfactory.
Externí odkaz:
https://doaj.org/article/0e3b46e589f74c6784ae1b2936175882
Publikováno v:
Cancer Communications, Vol 44, Iss 7, Pp 739-760 (2024)
Abstract Immunotherapy, particularly with immune checkpoint inhibitors, has significantly transformed cancer treatment. Despite its success, many patients struggle to respond adequately or sustain long‐lasting clinical improvement. A growing consen
Externí odkaz:
https://doaj.org/article/85912ae7e92543419e0557cbeeca5c02
Publikováno v:
陆军军医大学学报, Vol 46, Iss 13, Pp 1477-1486 (2024)
Objective To explore the sensitizing effect of manganese for radiotherapy against tumors and its possible mechanisms. Methods A total of 300 male C57BL/6 mice (6~8 weeks old, weighing 20~23 g) with subcutaneous tumor were randomly divided into 4 grou
Externí odkaz:
https://doaj.org/article/c06e0e6784c34c7589ce2a1666cebf1b
Publikováno v:
Bioactive Materials, Vol 36, Iss , Pp 541-550 (2024)
Systematic administration of small molecular drugs often suffered from the low efficacy and systemic toxicity in cancer therapy. In addition, application of single mode drug usually leads to unsatisfactory therapeutic outcomes. Currently, developing
Externí odkaz:
https://doaj.org/article/741c3b9529ab488d9e3197ac7217843a
Autor:
Wu-Yan Xia, Yu-Jia Shen, Chen-Chen Zhang, Li-Qiang Qian, Hao Wang, Kai Wang, Hai-Zhen Jin, Xue-Ru Zhu, Zheng-Ping Ding, Qin Zhang, Wen Yu, Wen Feng, Xiao-Long Fu
Publikováno v:
Translational Oncology, Vol 48, Iss , Pp 102074- (2024)
Patients with EGFR-mutated non-small cell lung cancer (NSCLC) respond poorly to immune checkpoint inhibitors (ICIs). It has been reported that the number of CD8+ T cells is reduced in EGFR-mutated NSCLC. However, the extent of heterogeneity and effec
Externí odkaz:
https://doaj.org/article/5eb143ce0a1a4c6da39f5d693b845017
Autor:
A. Gandini, V. Martelli, L. Belgioia, S. Puglisi, M. Cremante, V. Murianni, A. Damassi, C. Pirrone, F. Catalano, M. Grassi, L. Trevisan, S. Vagge, V. Andretta, S. Mammoliti, D. Comandini, G. Fornarini, A. Pessino, A. Pastorino, S. Sciallero, A. Puccini, A.F. Sobrero
Publikováno v:
ESMO Gastrointestinal Oncology, Vol 5, Iss , Pp 100069- (2024)
Background: Patients with metastatic colorectal cancer (mCRC) carrying a deficit in the mismatch repair system/microsatellite instability (dMMR/MSI) show great responses to immune checkpoint inhibitors. However, 30% of patients with dMMR/MSI are prim
Externí odkaz:
https://doaj.org/article/75eace6619974db0971a80c753cf7ddd
Publikováno v:
Urology Case Reports, Vol 56, Iss , Pp 102824- (2024)
We present the case of a 64-year-old patient with metastatic renal cell carcinoma, who experienced disease progression despite undergoing multiple lines of systemic therapy, including immune checkpoint inhibitors (ICI). Two months after stereotactic
Externí odkaz:
https://doaj.org/article/01b6feb1a1a7475590ca17beab5a395f
Autor:
Liman Qiu, Hongbing Ji, Kai Wang, Wenhan Liu, Qizhen Huang, Xinting Pan, Honghao Ye, Zhenli Li, Geng Chen, Xiaohua Xing, Xiuqing Dong, Ruijing Tang, Haipo Xu, Jingfeng Liu, Zhixiong Cai, Xiaolong Liu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 5, Pp 1193-1219 (2024)
Abstract Radiotherapy (RT) has been reported to induce abscopal effect in advanced hepatocellular carcinoma (HCC), but such phenomenon was only observed in sporadic cases. Here, we demonstrated that subcutaneous administration of Toll-like receptor 3
Externí odkaz:
https://doaj.org/article/bcba5366feb043319a556460d8015150