Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Abrey J Yeo"'
Autor:
Abrey J Yeo, Olivier J Becherel, John E Luff, Jason K Cullen, Thidathip Wongsurawat, Piroon Jenjaroenpun, Vladimir A Kuznetsov, Peter J McKinnon, Martin F Lavin
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90219 (2014)
Disruption of the Setx gene, defective in ataxia oculomotor apraxia type 2 (AOA2) leads to the accumulation of DNA/RNA hybrids (R-loops), failure of meiotic recombination and infertility in mice. We report here the presence of R-loops in the testes f
Externí odkaz:
https://doaj.org/article/795d1e476f5a48abafc5e5b7e4872206
Autor:
Olivier J Becherel, Abrey J Yeo, Alissa Stellati, Evelyn Y H Heng, John Luff, Amila M Suraweera, Rick Woods, Jean Fleming, Dianne Carrie, Kristine McKinney, Xiaoling Xu, Chuxia Deng, Martin F Lavin
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003435 (2013)
Senataxin, mutated in the human genetic disorder ataxia with oculomotor apraxia type 2 (AOA2), plays an important role in maintaining genome integrity by coordination of transcription, DNA replication, and the DNA damage response. We demonstrate that
Externí odkaz:
https://doaj.org/article/2ecf92590ec44c4b86789df144fc8688
Autor:
Shu-xian Li, Chao Li, Xin-ru Pang, Juan Zhang, Gong-chang Yu, Abrey J. Yeo, Martin F. Lavin, Hua Shao, Qiang Jia, Cheng Peng
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Long-term exposure to crystalline silica particles leads to silicosis characterized by persistent inflammation and progressive fibrosis in the lung. So far, there is no specific treatment to cure the disease other than supportive care. In this study,
Externí odkaz:
https://doaj.org/article/5d159afa657940dc889d9bc6bf212b24
Autor:
Abrey J. Yeo, Kok L. Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah Withey, Ernst Wolvetang, Robert G. Parton, Adam D. Brown, Michael B. Kastan, David Coman, Martin F. Lavin
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101972- (2021)
Summary: There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved. We demonstrate here that ATM-deficient cells are exquisitely sens
Externí odkaz:
https://doaj.org/article/395a2dfe24654d80a406b2e92e5fabf0
Autor:
Ayaho Yamamoto, Peter D Sly, Keng Yih Chew, Lavrent Khachatryan, Nelufa Begum, Abrey J Yeo, Luan D Vu, Kirsty R Short, Stephania A Cormier, Emmanuelle Fantino
Publikováno v:
Experimental Biology and Medicine. 248:271-279
Epidemiological evidence links lower air quality with increased incidence and severity of COVID-19; however, mechanistic data have yet to be published. We hypothesized air pollution-induced oxidative stress in the nasal epithelium increased viral rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c181b94cd4b1ec4fda06823dc2c26fd6
https://doi.org/10.1177/15353702221142616
https://doi.org/10.1177/15353702221142616
Autor:
Martin F. Lavin, Abrey J. Yeo
Publikováno v:
Neuron. 109:3897-3900
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4144362573de8ad8916d98fc20bed2a7
https://doi.org/10.1016/j.neuron.2021.11.019
https://doi.org/10.1016/j.neuron.2021.11.019
Autor:
Xinru Pang, Haojun Shi, Xiaoshu Chen, Chao Li, Bin Shi, Abrey J. Yeo, Martin F. Lavin, Qiang Jia, Hua Shao, Juan Zhang, Gongchang Yu
Publikováno v:
Environmental toxicologyREFERENCES. 37(8)
Silica dust particles are representative of air pollution and long-term inhalation of silicon-containing dust through the respiratory tract can cause pulmonary fibrosis. Epithelial-mesenchymal transformation (EMT) plays an important role in the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99edd778e5f07d647acbdb398695f26a
https://pubmed.ncbi.nlm.nih.gov/35499148
https://pubmed.ncbi.nlm.nih.gov/35499148
Autor:
Xiaoshu Chen, Xinru Pang, Abrey J. Yeo, Siwen Xie, Mengting Xiang, Bin Shi, Gongchang Yu, Chao Li
Publikováno v:
Frontiers in cellular neuroscience. 16
The blood-brain barrier (BBB) is a selective, semi-permeable layer of endothelial cells that protects the central nervous system from harmful substances circulating in blood. It is one of the important barriers of the nervous system. BBB dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be70f93ae24d3af0c7cd1361014fae3
https://pubmed.ncbi.nlm.nih.gov/35663422
https://pubmed.ncbi.nlm.nih.gov/35663422
Autor:
U Wang Lei, Abrey J. Yeo, Keerat Junday, Ashmitha Sundarrajan, Michelle Pewarchuk, Hannah C Leeson, Amanda W. Kijas, Ernst J. Wolvetang, Sarah L. Withey, Dmitry A. Ovchinnikov, Martin F. Lavin
Publikováno v:
Human Molecular Genetics. 29:990-1001
Patients with ataxia-telangiectasia (A-T) lack a functional ATM kinase protein and exhibit defective repair of DNA double-stranded breaks and response to oxidative stress. We show that CRISPR/Cas9-assisted gene correction combined with piggyBac (PB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4be0a21c534d1c7e2c36bc1c00b09a
https://doi.org/10.1093/hmg/ddaa023
https://doi.org/10.1093/hmg/ddaa023
Autor:
Qiang Jia, Abrey J. Yeo, Xiaoqun Wang, Cunxiang Bo, Yu Zhang, Linlin Sai, Hua Shao, Martin F. Lavin, Cheng Peng, Gongchang Yu
Publikováno v:
Toxicology Letters. 317:59-67
Toluene-diisocyanate (TDI) is mainly used in the manufacturing process of polyurethane foams, and is a potent inducer of occupational asthma characterized by airway inflammation and airway hyperreactivity. Thymic stromal lymphopoietin (TSLP) plays an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff97c9de419f19da9111e8f423d42ee6
https://doi.org/10.1016/j.toxlet.2019.09.021
https://doi.org/10.1016/j.toxlet.2019.09.021