Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Abrar E Al-Shaer"'
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006937 (2019)
Gestational alcohol exposure causes fetal alcohol spectrum disorder (FASD) and is a prominent cause of neurodevelopmental disability. Whole transcriptome sequencing (RNA-Seq) offer insights into mechanisms underlying FASD, but gene-level analysis pro
Externí odkaz:
https://doaj.org/article/c3f9dc3218e74acb8aade7bec71d45a7
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Resolvin E1 (RvE1) is an immunoresolvent that is synthesized from eicosapentaenoic acid and can bind the receptor ERV1/ChemR23. We previously showed activation of the RvE1-ChemR23 axis improves hyperglycemia and hyperinsulinemia of obese mice; howeve
Externí odkaz:
https://doaj.org/article/907063cde0ea4be7b9e2931d4cbd13f1
Autor:
Nancie J. MacIver, J. Justin Milner, Saame Raza Shaikh, Qing Shi, Melinda A. Beck, Abrar E. Al-Shaer, Kymberly M Gowdy, William R. Green
Publikováno v:
Journal of Leukocyte Biology. 111:147-159
Obesity is an independent risk factor for morbidity and mortality in response to influenza infection. However, the underlying mechanisms by which obesity impairs immunity are unclear. Herein, we investigated the effects of diet-induced obesity on pul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::610b28965a4124edac31bbe1593a1156
https://doi.org/10.1002/jlb.4a0120-075rr
https://doi.org/10.1002/jlb.4a0120-075rr
Autor:
Abrar E. Al‐Shaer, Anandita Pal, Qing Shi, Meredith S. Carson, Jennifer Regan, Madeline Behee, Nicole Buddenbaum, Catie Drawdy, Traci Davis, Rafia Virk, Saame Raza Shaikh
Publikováno v:
FASEB J
Resolvin E1 (RvE1), a specialized pro-resolving mediator (SPM), improves glucose homeostasis in inbred mouse models of obesity. However, an impediment toward translation is that obesity is a highly heterogenous disease in which individuals will respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52de121da8b3e36bb83ea16e12bc32fe
https://pubmed.ncbi.nlm.nih.gov/35616343
https://pubmed.ncbi.nlm.nih.gov/35616343
Autor:
Abrar E Al-Shaer, Jennifer Regan, Nicole Buddenbaum, Sonum Tharwani, Catie Drawdy, Madeline Behee, Selin Sergin, Jenifer I Fenton, Krishna Rao Maddipati, Shawn Kane, Erik Butler, Saame Raza Shaikh
Publikováno v:
J Nutr
BACKGROUND: Specialized pro-resolving mediators (SPMs), synthesized from PUFAs, resolve inflammation and return damaged tissue to homeostasis. Thus, increasing metabolites of the SPM biosynthetic pathway may have potential health benefits for select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0f04a18c5f3af6ef2dad641e3f2c0d
https://europepmc.org/articles/PMC9258560/
https://europepmc.org/articles/PMC9258560/
Autor:
William D, Green, Abrar E, Al-Shaer, Qing, Shi, Kymberly M, Gowdy, Nancie J, MacIver, J Justin, Milner, Melinda A, Beck, Saame Raza, Shaikh
Publikováno v:
J Leukoc Biol
Obesity is an independent risk factor for morbidity and mortality in response to influenza infection. However, the underlying mechanisms by which obesity impairs immunity are unclear. Herein, we investigated the effects of diet-induced obesity on pul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80d068f3a36d9e41807f6ae5817d8923
https://pubmed.ncbi.nlm.nih.gov/33847405
https://pubmed.ncbi.nlm.nih.gov/33847405
Autor:
Qing Shi, Melinda A. Beck, Abrar E. Al-Shaer, Nancie J. MacIver, Saame Raza Shaikh, William R. Green
BackgroundObesity increases influenza disease risk in millions of adults worldwide. In this study, we investigated the effect of diet-induced obesity on pulmonary CD8+ T cell metabolism and function as a mechanism of impairment.MethodsMale C57BL/6J m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371f99034b1431f5fdb625213ed25e1b
Autor:
Michael Armstrong, Ian M. Carroll, P. Darrell Neufer, Traci Davis, Abrar E. Al-Shaer, Espen E. Spangenburg, Saame Raza Shaikh, Joan Clària, Richard P. Bazinet, Maria J. Torres, William Guesdon, Nichole Reisdorph, Ganesh V. Halade, Anandita Pal, Kevin Quinn
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
The FASEB Journal
Universidad de Barcelona
The FASEB Journal
Aims Eicosapentaenoic acid (EPA) is consumed in low levels in the western diet. Increased consumption of EPA may prevent impairments in insulin-glucose homeostasis that contribute toward cardiometabolic disorders. Here we investigated how EPA, throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21470b236e310bdb3057e01864ca0d4
http://hdl.handle.net/2445/175453
http://hdl.handle.net/2445/175453
Publikováno v:
Biochim Biophys Acta Mol Cell Biol Lipids
Chronic inflammation contributes toward the pathogenesis of numerous diseases including, but not limited to, obesity, autoimmunity, cardiovascular diseases, and cancers. The discovery of specialized pro-resolving mediators (SPMs), which are critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c554782a020947f508ef24b8a8f8c0
https://doi.org/10.1016/j.bbalip.2021.158936
https://doi.org/10.1016/j.bbalip.2021.158936
Publikováno v:
Mol Nutr Food Res
Diet-induced obesity is associated with impaired B-cell-driven humoral immunity, which coincides with chronic inflammation and has consequences for responses to infections and vaccinations. Key nutritional, cellular, and molecular mechanisms by which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bb7635c4a63fa6f3df7da3c96ae326
https://doi.org/10.1002/mnfr.201900924
https://doi.org/10.1002/mnfr.201900924