Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Abramova Mv"'
Autor:
Valery A. Pospelov, S. B. Svetlikova, Nikolai D. Aksenov, Kukushkin An, Tatiana V. Pospelova, Abramova Mv
Publikováno v:
Cancer Biology & Therapy. 12:1069-1077
HDAC inhibitors (HDACi) suppress the growth of tumor cells due to induction of cell cycle arrest, senescence or apoptosis. Recent data demonstrate that HDACi can interfere with DNA Damage Response (DDR) thereby sensitizing the cells to DNA damaging a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae4c9ba1263aeaa4ebc479e47f96efe
https://doi.org/10.4161/cbt.12.12.18365
https://doi.org/10.4161/cbt.12.12.18365
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 42:1847-1855
HDAC inhibitors (HDACIs) are capable of suppressing the cell growth of tumour cells due to the induction of apoptosis and/or cell cycle arrest. This allows of considering HDACIs as promising agents for tumour therapy. The final outcome – apoptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85e714bb2bdc5549e39c567948d6ff8
https://doi.org/10.1016/j.biocel.2010.08.001
https://doi.org/10.1016/j.biocel.2010.08.001
Publikováno v:
Biochemical and Biophysical Research Communications. 391:142-146
HDAC inhibitors induce cell cycle arrest of E1A+Ras-transformed cells accompanied by e2f1 gene down-regulation and activation of Wnt pathway. Here we show that e2f1 expression is regulated through the Wnt/Tcf-pathway: e2f1 promoter activity is inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af90be488eecb2e0a2600033798138a7
https://doi.org/10.1016/j.bbrc.2009.11.020
https://doi.org/10.1016/j.bbrc.2009.11.020
Publikováno v:
Biochemical and Biophysical Research Communications. 306:483-487
Transformation of REF cells by oncogenes E1A and cHa-ras leads to activation of AP-1 factor concomitantly with down-regulation of c-fos gene transcription. Here we addressed two issues: (i) how does transcription of Fos/Jun-regulated genes change in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfa8602b745185fa156cb222fd15cf1
https://doi.org/10.1016/s0006-291x(03)00996-3
https://doi.org/10.1016/s0006-291x(03)00996-3
Publikováno v:
Molecular Biology. 36:50-57
As compared with normal rat embryo fibroblasts (REF), c-fos transcription is suppressed in REF transformed with the E1A and cHa-ras complementing oncogenes. Negative regulation of the fos promoter is due to the serum-responsive element (SRE) constant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdc62d255a395f9d35e4e8ddebb7c7dc
https://doi.org/10.1023/a:1014294306405
https://doi.org/10.1023/a:1014294306405
Autor:
Valery A. Pospelov, Vasily S. Romanov, Svetlana G. Zubova, S. B. Svetlikova, Albert J. Fornace, Tatiana V. Pospelova, Bykova Tv, Abramova Mv, Nikolai D. Aksenov
Publikováno v:
Cell cycle (Georgetown, Tex.). 9(19)
Cell senescence is characterized by senescent morphology and permanent loss of proliferative potential. HDAC inhibitors (HDACI) induce senescence and/or apoptosis in many types of tumor cells. Here, we studied the role of cyclin-kinase inhibitor p21(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760347836a5baf8b2a38010daee8e007
https://pubmed.ncbi.nlm.nih.gov/20935470
https://pubmed.ncbi.nlm.nih.gov/20935470
Autor:
Tatiana V. Pospelova, Valery A. Pospelov, Abramova Mv, Fedor P. Nikulenkov, Albert J. Fornace, Christine M. Hollander
Publikováno v:
The Journal of biological chemistry. 281(30)
Tumor cells are often characterized by a high and growth factor-independent proliferation rate. We have previously shown that REF cells transformed with oncogenes E1A and c-Ha-Ras do not undergo G(1)/S arrest of the cell cycle after treatment with ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad2bd7628d267dcc1e3b419385f46ca
https://pubmed.ncbi.nlm.nih.gov/16717102
https://pubmed.ncbi.nlm.nih.gov/16717102
Autor:
Kukushkin An, Valery A. Pospelov, Tatiana V. Pospelova, Zalfia A Darieva, Abramova Mv, S. B. Svetlikova
Publikováno v:
Oncogene. 21(5)
REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the transcription of c-fos gene has been found to be downregulated. To elucidate the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11225817e4b7b261c1cc039d49039a32
https://pubmed.ncbi.nlm.nih.gov/11850800
https://pubmed.ncbi.nlm.nih.gov/11850800
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Akademický článek
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