Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Abram Handly‐Santana"'
Autor:
Stephanie Kong, Pearl Moharil, Abram Handly‐Santana, Natalie Boehnke, Richard Panayiotou, Victoria Gomerdinger, Gil Covarrubias, Ivan S. Pires, Ioannis Zervantonakis, Joan Brugge, Paula T. Hammond
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 2, Pp n/a-n/a (2023)
Abstract The majority of patients with high grade serous ovarian cancer (HGSOC) develop recurrent disease and chemotherapy resistance. To identify drug combinations that would be effective in treatment of chemotherapy resistant disease, we examined t
Externí odkaz:
https://doaj.org/article/0fdb0c64b4324a05901ffd1980280b58
Autor:
Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa Yao, Faith Gorton, Junwei Shi, Craig J. Thomas, Lauren E. Brown, John A. Porco, Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and gl
Externí odkaz:
https://doaj.org/article/5805d19b9df44bceaf4b4ac6e534ad64
Autor:
Martina S.J. McDermott, Neil A. O'Brien, Benjamin Hoffstrom, KeWei Gong, Ming Lu, Jun Zhang, Tong Luo, Min Liang, Weiping Jia, Jenny J. Hong, Kevin Chau, Simon Davenport, Bin Xie, Michael F. Press, Richard Panayiotou, Abram Handly-Santana, Joan S. Brugge, Leonard Presta, John Glaspy, Dennis J. Slamon
Publikováno v:
Clinical Cancer Research. 29:2131-2143
Purpose: Claudin-6 (CLDN6) is expressed at elevated levels in multiple human cancers including ovarian and endometrial malignancies, with little or no detectable expression in normal adult tissue. This expression profile makes CLDN6 an ideal target f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::186047a357d2071af85ad13afa3d9bae
https://doi.org/10.1158/1078-0432.ccr-22-2981
https://doi.org/10.1158/1078-0432.ccr-22-2981
Autor:
Dennis J. Slamon, John Glaspy, Leonard Presta, Joan S. Brugge, Abram Handly-Santana, Richard Panayiotou, Michael F. Press, Bin Xie, Simon Davenport, Kevin Chau, Jenny J. Hong, Weiping Jia, Min Liang, Tong Luo, Jun Zhang, Ming Lu, KeWei Gong, Benjamin Hoffstrom, Neil A. O'Brien, Martina S.J. McDermott
Supplemental Figure S2: Amino acid sequence alignment of CLDN6 (P56747) and CLDN9 (O95484) with the extracellular loops highlighted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f31f48fad690aefa9ed719ee8489c6
https://doi.org/10.1158/1078-0432.22587098
https://doi.org/10.1158/1078-0432.22587098
Autor:
Dennis J. Slamon, John Glaspy, Leonard Presta, Joan S. Brugge, Abram Handly-Santana, Richard Panayiotou, Michael F. Press, Bin Xie, Simon Davenport, Kevin Chau, Jenny J. Hong, Weiping Jia, Min Liang, Tong Luo, Jun Zhang, Ming Lu, KeWei Gong, Benjamin Hoffstrom, Neil A. O'Brien, Martina S.J. McDermott
Methods for Supplemental Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bce6b4d12bf72c622fb320a86e1ecd
https://doi.org/10.1158/1078-0432.22587077
https://doi.org/10.1158/1078-0432.22587077
Autor:
Dennis J. Slamon, John Glaspy, Leonard Presta, Joan S. Brugge, Abram Handly-Santana, Richard Panayiotou, Michael F. Press, Bin Xie, Simon Davenport, Kevin Chau, Jenny J. Hong, Weiping Jia, Min Liang, Tong Luo, Jun Zhang, Ming Lu, KeWei Gong, Benjamin Hoffstrom, Neil A. O'Brien, Martina S.J. McDermott
Purpose:Claudin-6 (CLDN6) is expressed at elevated levels in multiple human cancers including ovarian and endometrial malignancies, with little or no detectable expression in normal adult tissue. This expression profile makes CLDN6 an ideal target fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7453626687b6f997a6df7cd4f91fd346
https://doi.org/10.1158/1078-0432.c.6571949.v1
https://doi.org/10.1158/1078-0432.c.6571949.v1
Autor:
Dennis J. Slamon, John Glaspy, Leonard Presta, Joan S. Brugge, Abram Handly-Santana, Richard Panayiotou, Michael F. Press, Bin Xie, Simon Davenport, Kevin Chau, Jenny J. Hong, Weiping Jia, Min Liang, Tong Luo, Jun Zhang, Ming Lu, KeWei Gong, Benjamin Hoffstrom, Neil A. O'Brien, Martina S.J. McDermott
File containing supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24338cd0e5788a80b222542c494e0a88
https://doi.org/10.1158/1078-0432.22587074
https://doi.org/10.1158/1078-0432.22587074
Autor:
Stephanie Kong, Pearl Moharil, Abram Handly‐Santana, Natalie Boehnke, Richard Panayiotou, Victoria Gomerdinger, Gil Covarrubias, Ivan S. Pires, Ioannis Zervantonakis, Joan Brugge, Paula T. Hammond
Publikováno v:
Bioengineering & Translational Medicine. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2efb89efed20c9d48e98b386f113ecb
https://doi.org/10.1002/btm2.10429
https://doi.org/10.1002/btm2.10429
Autor:
Martina S. McDermott, Ke Wei Gong, Neil A. O'Brien, Dylan Conklin, Benjamin Hoffstrom, Ming Lu, Jun Zhang, Tong Luo, Weiping Jia, Jenny J. Hong, Kevin Chau, Simon Davenport, Michael F. Press, Abram Handly-Santana, Joan S. Brugge, Ronny Drapkin, John A. Glaspy, Leonard Presta, Dennis J. Slamon
Publikováno v:
Cancer Research. 82:342-342
Background: Claudin 6 (CLDN6), a member of the claudin family of tight junction proteins, is expressed at high levels in multiple human malignancies including ovarian and endometrial cancers. Conversely it has little or no expression in normal tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd883071859dd87d3fccd96831eefc8d
https://doi.org/10.1158/1538-7445.am2022-342
https://doi.org/10.1158/1538-7445.am2022-342
Autor:
Mariano Ponz-Sarvise, Abram Handly-Santana, David A. Tuveson, Vincenzo Corbo, Iok In Christine Chio, Lindsey A. Baker, Eun Jung Lee, Dannielle D. Engle, Mikala Egeblad, Stephen Hearn, Douglas T. Fearon, Christine Feig, Giulia Biffi, Hans Clevers, Chang-Il Hwang, Ana S. Almeida, Tobiloba E. Oni, Hervé Tiriac, Daniel Öhlund, Ela Elyada, Young-Kyu Park, James M. Crawford, Anne Kultti
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 214(3), 579-596. Rockefeller University Press
The Journal of experimental medicine, vol 214, iss 3
Journal of Experimental Medicine, 214(3), 579. Rockefeller University Press
Journal of Experimental Medicine, 214(3), 579-596. Rockefeller University Press
The Journal of experimental medicine, vol 214, iss 3
Journal of Experimental Medicine, 214(3), 579. Rockefeller University Press
Öhlund et al. develop a three-dimensional co-culture platform of neoplastic pancreatic ductal organoids and pancreatic stellate cells (PSCs) to characterize the dynamic crosstalk between cancer cells and stromal cells, and to address stromal heterog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec1441ac4a16e9419ef1d76dc992ecc
https://hdl.handle.net/20.500.11755/5c35c003-6f17-4c49-9729-51e2a031bc3e
https://hdl.handle.net/20.500.11755/5c35c003-6f17-4c49-9729-51e2a031bc3e