Výsledky vyhledávání - "Abraian Miller"

Honokiol-Loaded Methoxy Poly (Ethylene Glycol) Polycaprolactone Micelles for the Treatment of Age-Related Macular Degeneration

Autor: Priyanka Bhatt, Abraian Miller, Amna Shahid, Vijaykumar Sutariya

Publikováno v: ASSAY and Drug Development Technologies. 19:350-360

Age-related macular degeneration (AMD), a multifactorial age-related retinal hypoxic disorder resulting in irreversible loss of vision, is the foremost cause of blindness in the United States. Current treatment strategies involve multiple intraocular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309808679e21e9f4d7e5a9fcacb63ffb
https://doi.org/10.1089/adt.2021.003

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The role of hypusinated eIF5A in TDP‐43 cytoplasmic sequestration in AD and TDP‐43 related dementia

Autor: Dale Chaput, Maj-Linda B. Selenica, Daniel C. Lee, Abraian Miller, Frank Zamudio, Shayna Smeltzer, Zainnudin Quadri

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e430f74254ce43590fc146ee7de737d
https://doi.org/10.1002/alz.038432

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Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model

Autor: Sheba Saji, Nicholas J. F. Stewart, Jordan Hunter, Abraian Miller, Zainuddin Quadri, Maj-Linda B. Selenica, Daniel C. Lee, Shayna Smeltzer, Dale Chaput, Frank Zamudio

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1867:165939

TAR DNA-binding protein 43 (TDP-43) is a nuclear RNA/DNA binding protein involved in mRNA metabolism. Aberrant mislocalization to the cytoplasm and formation of phosphorylated/aggregated TDP-43 inclusions remains the hallmark pathology in a spectrum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8468dbdd2b009ae39e08d7f4f8336e0d
https://doi.org/10.1016/j.bbadis.2020.165939

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Overexpression of human wtTDP-43 causes impairment in hippocampal plasticity and behavioral deficits in CAMKII-tTa transgenic mouse model

Autor: Daniel C. Lee, Melinda M. Peters, Edwin J. Weeber, Frank Zamudio, Nicholas Johnson, Kevin Nash, Jerry B. Hunt, Abraian Miller, Christopher M. Norris, Maj-Linda B. Selenica, Zainuddin Quadri, Susan D. Kraner, Steven B. Housley, Breanna Brown, Shayna Smeltzer

Publikováno v: Mol Cell Neurosci

Aims The current study utilizes the adeno-associated viral gene transfer system in the CAMKIIα-tTA mouse model to overexpress human wild type TDP-43 (wtTDP-43) and α-synuclein (α-Syn) proteins. The co-existence of these proteins is evident in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cfb6160f2982abd1751af9858a0120
https://doi.org/10.1016/j.mcn.2019.103418

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