Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.

Autor: Abrahamsen HL; Department of Microbiology & Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Sanford TC; Department of Microbiology & Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Collamore CE; Department of Microbiology & Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Johnstone BA; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia., Coyne MJ; Duchossois Family Institute and Department of Microbiology, University of Chicago, Chicago, IL, USA., García-Bayona L; Duchossois Family Institute and Department of Microbiology, University of Chicago, Chicago, IL, USA., Christie MP; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia., Evans JC; Department of Microbiology & Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Wheeler Bio, Oklahoma City, OK, 73104, USA., Farrand AJ; Department of Microbiology & Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Wheeler Bio, Oklahoma City, OK, 73104, USA., Flores K; Duchossois Family Institute and Department of Microbiology, University of Chicago, Chicago, IL, USA., Morton CJ; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.; CSIRO Biomedical Manufacturing Program, Clayton, VIC, 3168, Australia., Parker MW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia. mwp@unimelb.edu.au.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia. mwp@unimelb.edu.au.; Australian Cancer Research Foundation Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, VIC, 2065, Australia. mwp@unimelb.edu.au., Comstock LE; Duchossois Family Institute and Department of Microbiology, University of Chicago, Chicago, IL, USA. lecomstock@uchicago.edu., Tweten RK; Department of Microbiology & Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. rod-tweten@ouhsc.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 12; Vol. 15 (1), pp. 5028. Date of Electronic Publication: 2024 Jun 12.