Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Abraham Sunshine"'
Publikováno v:
Osteoarthritis and Cartilage. 14:1111-1118
SummaryBackgroundOsteoarthritis (OA) is frequently treated only during periods of flare, in which rapid onset of analgesia is the outcome target.ObjectiveTo assess an acute pain model of knee OA in flare.MethodsIn a multicenter, randomized, double-bl
Autor:
Nancy Z. Olson, Angel M. Otero, Stephen A. Cooper, Geraldine Doyle, Shyamalie Jayawardena, Ivan Marrero, Abraham Sunshine, Sylma Tirado
Publikováno v:
The Journal of Clinical Pharmacology. 41:1238-1247
Ibuprofen is a peripherally acting nonsteroidal anti-inflammatory drug indicated fo ranalgesia, antipyresis, and various arthritic conditions. A solubilized 200 mg liquigel formulation of ibuprofen has been shown to have a more rapid rate of absorpti
Autor:
Abraham Sunshine
Publikováno v:
The Journal of Pain. 1:10-13
The newer COX-2 drugs are safer analgesics than the older NSAIDs. At the usual dose used in osteoarthritis, they have less analgesic effect than the older NSAIDs. The non-narcotic analgesics such as acetaminophen, salicylate, NSAIDs, and the newer CO
Publikováno v:
The Journal of Clinical Pharmacology. 37:908-915
Hydrocodone is a semisynthetic opioid with analgesic and antitussive properties qualitatively similar to other opioid agonists. Ibuprofen is a nonsteroidal antiinflammatory agent with analgesic and antipyretic activity and is an effective, primarily
Autor:
Ivan Marrero, Nancy Z. Olson, Sylma Tirado, Eugene M. Laska, Carole Siegel, Abraham Sunshine, Robert F. Kaiko
Publikováno v:
American Journal of Therapeutics. 3:427-434
Autor:
Abraham Sunshine
Publikováno v:
Drugs. 47:8-18
The analgesic efficacy of tramadol has been recently reassessed as part of a new clinical development programme to support an application for registration in the USA. This article reviews the results of single dose and short term studies of oral tram
Publikováno v:
Clinical Pharmacology and Therapeutics. 51:740-746
Tramadol hydrochloride is a synthetic opiate agonist with a plasma elimination half-life of 5 to 6 hours and peak plasma levels at about 1½ hours. It derives its activity from attachment to the μ-receptor and blockage of norepinephrine reuptake. Th
Publikováno v:
Clinical Pharmacology and Therapeutics. 49:1-5
Autor:
Arthur Elkind, Nancy Z. Olson, Carolyn R. Sikes, Abraham Sunshine, Mary Almas, Serena A. Mulhern
Publikováno v:
Clinical therapeutics. 28(8)
Background: The standard measure of efficacy used in migraine trials is a 4-point patient-rated headache pain intensity (HPI) scale. However, it has been suggested that using a stopwatch to measure the time to meaningful pain relief can provide a mor
Autor:
Timothy R. Smith, Susan E. Spruill, W. James Alexander, Diane E. Littlefield, Stuart R. Stark, Abraham Sunshine
Publikováno v:
Headache. 45(8)
Objective.—To evaluate the efficacy and tolerability of treatment with a combination of sumatriptan 50 mg (encapsulated) and naproxen sodium 500 mg administered concurrently in the acute treatment of migraine. Background.—The pathogenesis of migr