Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Abraham P. Fong"'
Autor:
Abraham P. Fong, Zizhen Yao, Jun Wen Zhong, Nathan M. Johnson, Gist H. Farr III, Lisa Maves, Stephen J. Tapscott
Publikováno v:
Cell Reports, Vol 10, Iss 12, Pp 1937-1946 (2015)
MyoD and NeuroD2, master regulators of myogenesis and neurogenesis, bind to a “shared” E-box sequence (CAGCTG) and a “private” sequence (CAGGTG or CAGATG, respectively). To determine whether private-site recognition is sufficient to confer li
Externí odkaz:
https://doaj.org/article/2a676e3ab3cb4b6da4a74187b1009696
Autor:
Guillermo Garcia-Manero, Amanda Przespolewski, Yasmin Abaza, Michael Byrne, Abraham P. Fong, Feng Jin, Alison J. Forgie, Athanasios C. Tsiatis, Shanhong Guan, Harry P. Erba
Publikováno v:
Blood. 140:9046-9047
Autor:
Srinivasa R. Sanikommu, Abraham P. Fong, Guillermo Garcia-Manero, Hamid Sayar, Bart L. Scott, Alison Forgie, Sophia Randolph, Jaume Pons, Michael Byrne, Jessica K. Altman, Shanhong Guan, Feng Jin, Harry P. Erba
Publikováno v:
Blood. 138:2601-2601
Background: Evorpacept is a high affinity CD47-blocking fusion protein with an inactive human immunoglobulin Fc region designed to enhance the activity of other anti-neoplastic therapies, such as azacitidine (AZA), with minimal additional toxicity. H
Autor:
Sophia Randolph, Alison Forgie, Ons Harrabi, Hong Wan, Jaume Pons, Tracy C. Kuo, Katherine Ruffner, Amy Y. Chen, Janet Sim, Abraham P. Fong
Publikováno v:
Blood. 136:15-16
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with most patients relapsing even after initial therapies. Despite recent advances in treatment, the development of efficacious novel treatments remains an unmet need. CD47 is a mye
Autor:
Dirk Huebner, Emily K. Larsen, Scott E. Smith, Joseph D. Rosenblatt, Stephen M. Ansell, Joseph M. Connors, Ajay K. Gopal, Anas Younes, Kerry J. Savage, Robert T. Chen, Abraham P. Fong, Andreas Engert
Publikováno v:
Blood. 128:1562-1566
Presented here are the 5-year end-of-study results from the pivotal phase 2 trial of brentuximab vedotin in patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) after failed hematopoietic autologous stem cell transplantation. At 5 years, the
Autor:
Yinghui Wang, Andres Forero-Torres, Robert T. Chen, Christopher A. Yasenchak, Vivian Jean M. Cline, Patrick J. Flynn, Dipti Patel Donnelly, Abraham P. Fong, Rodolfo Bordoni, Jonathan W. Friedberg, Gregg Olsen
Publikováno v:
Blood. 130(26)
Patients aged ≥60 years with treatment-naive Hodgkin lymphoma (HL) have few treatment options and inferior survival due to treatment-related toxicities and comorbidities. This phase 2, nonrandomized, open-label study evaluated brentuximab vedotin (
Autor:
Zizhen Yao, Abraham P. Fong, Walter L. Ruzzo, Kyle L. MacQuarrie, Robert Gentleman, Stephen J. Tapscott
Publikováno v:
Bioinformatics. 30:775-783
Motivation: High-throughput ChIP-seq studies typically identify thousands of peaks for a single transcription factor (TF). It is common for traditional motif discovery tools to predict motifs that are statistically significant against a naïve backgr
Autor:
Abraham P. Fong, Stephen J. Tapscott
Publikováno v:
Current Opinion in Genetics & Development. 23:568-573
The discovery of the transcription factor MyoD and its ability to induce muscle differentiation was the first demonstration of genetically programmed cell transdifferentiation. MyoD functions by activating a feed-forward circuit to regulate muscle ge
Autor:
Kyle L. MacQuarrie, Zizhen Yao, Douglas S. Hawkins, Abraham P. Fong, Stephen J. Tapscott, Scott J. Diede, Erin R. Rudzinski
Publikováno v:
Molecular and Cellular Biology. 33:773-784
Rhabdomyosarcoma is a pediatric tumor of skeletal muscle that expresses the myogenic basic helix-loop-helix protein MyoD but fails to undergo terminal differentiation. Prior work has determined that DNA binding by MyoD occurs in the tumor cells, but
Publikováno v:
Genes & Development. 25:997-1003
Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and d