Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Abraham M. deVos"'
Publikováno v:
Pharmaceutical Research. 18:1455-1460
Purpose. The primary objective of this study was to compare the effects of light-and chemical-induced oxidation of recombinant human vascular endothelial growth factor (rhVEGF) and the impact of these reactions on protein formulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8b5ac50a97503e5f1e25e097ebc3058
https://doi.org/10.1023/a:1012261024249
https://doi.org/10.1023/a:1012261024249
Autor:
Axel T. Brunger, Eiko Ohtsuka, Jarmila Jancarik, Sung-Hou Kim, Susumu Nishimura, Abraham M. deVos, Liang Tong, Ziro Yamaizumi, M. V. Milburn
Publikováno v:
Proceedings of the National Academy of Sciences. 87:4849-4853
Normal RAS proteins play a key role of molecular switch in the transduction of the growth signal from extracellular to intracellular space. The state of the switch is "on" when GTP is bound and "off" when GDP is bound to the protein. The crystal stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf260790873e7f29c1ad4b8853ac0fd
https://doi.org/10.1073/pnas.87.12.4849
https://doi.org/10.1073/pnas.87.12.4849
Autor:
James A. Wells, Michael G. Mulkerrin, Germaine Fuh, Steven H. Bass, Henry B. Lowman, Abraham M. DeVos, Mark Ultsch, Brian C. Cunningham
High-resolution mutational and structural analyses of purified components have revealed a great deal about the molecular basis for growth hormone action. The structural and functional aspects of the interactions between hGH and its receptors have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8893ee6151b3d4e4a9b963e946ddbf5
https://doi.org/10.1016/b978-0-12-571148-7.50013-0
https://doi.org/10.1016/b978-0-12-571148-7.50013-0
Publikováno v:
Proteins. 11(1)
The contribution of His64 to the function and stability of tissue plasminogen activator (t-PA) kringle-2 domain (His244 in t-PA numbering) has been studied by using microcalorimetric methods to compare the ligand binding and thermal denaturation beha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f78659cc7770af58ee41adadec1c775
https://pubmed.ncbi.nlm.nih.gov/1961700
https://pubmed.ncbi.nlm.nih.gov/1961700
Autor:
Axel T. Brunger, Sung-Hou Kim, M. V. Milburn, Ziro Yamaizumi, Abraham M. deVos, Susumu Nishimura, Liang Tong
Publikováno v:
Science (New York, N.Y.). 247(4945)
Ras proteins participate as a molecular switch in the early steps of the signal transduction pathway that is associated with cell growth and differentiation. When the protein is in its GTP complexed form it is active in signal transduction, whereas i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099ab3f0cec16aa09e0ed2173ac0ef9b
https://pubmed.ncbi.nlm.nih.gov/2406906
https://pubmed.ncbi.nlm.nih.gov/2406906