Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Abraham M. Sheffield"'
Publikováno v:
Headneck. 40(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082a94f9c95b035cd9e05f70c424f195
https://pubmed.ncbi.nlm.nih.gov/30475416
https://pubmed.ncbi.nlm.nih.gov/30475416
Autor:
Michael S. Hildebrand, Stephen S. Newton, Richard J.H. Smith, John A. Chiorini, Abraham M. Sheffield, Giovanni Di Pasquale, Samuel P. Gubbels
Publikováno v:
Hearing Research. 277:28-36
Gene-based therapeutics are being developed as novel treatments for genetic hearing loss. One roadblock to effective gene therapy is the identification of vectors which will safely deliver therapeutics to targeted cells. The cellular heterogeneity th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245c08724db736208e6677fc120c23e3
https://doi.org/10.1016/j.heares.2011.03.016
https://doi.org/10.1016/j.heares.2011.03.016
Autor:
Farkhondeh Habibi, Guy Van Camp, Nicole C. Meyer, Nele Hilgert, Abraham M. Sheffield, Richard J.H. Smith, Matthew R. Avenarius, Ahmad Daneshi, Niloofar Bazazzadegan, Hossein Najmabadi, Carla Nishimura, Masoomeh Sobhani, Kimia Kahrizi, Seyedeh Sedigheh Abedini, Mohammad Farhadi
Publikováno v:
American journal of medical genetics : part A
Mutations in GJB2, encoding connexin 26 (Cx26), cause both autosomal dominant and autosomal recessive nonsyndromic hearing loss at the DFNA3 and DFNB1 loci, respectively. Most of the over 100 described GJB2 mutations cause autosomal recessive nonsynd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f39d4282b91092d21c84c337ff836e2
https://doi.org/10.1002/ajmg.a.33209
https://doi.org/10.1002/ajmg.a.33209
Publikováno v:
Cold Spring Harb Perspect Med
Hearing loss is the most common sensory deficit worldwide. It affects ∼5% of the world population, impacts people of all ages, and exacts a significant personal and societal cost. This review presents epidemiological data on hearing loss. We discus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09b2e25e537d66439c116ca7d003d31
https://doi.org/10.1101/cshperspect.a033258
https://doi.org/10.1101/cshperspect.a033258
Publikováno v:
Advances in oto-rhino-laryngology. 66
Targeting and down-regulating specific genes with antisense and decoy oligonucleotides, ribozymes or RNA interference (RNAi) offers the theoretical potential of altering a disease phenotype. This article reviews the molecular mechanism behind the in-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4996f78d3cd3ecb20ef618b622265b
https://pubmed.ncbi.nlm.nih.gov/19494570
https://pubmed.ncbi.nlm.nih.gov/19494570
Autor:
Stephen S. Newton, Michelle G. de Silva, Amit Kochhar, Scott D. Rose, Abraham M. Sheffield, Hans-Henrik M. Dahl, Richard J.H. Smith, Mark A. Behlke, Michael S. Hildebrand, Samuel P. Gubbels
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 16(2)
Development of effective therapeutics for hearing loss has proven to be a slow and difficult process, evidenced by the lack of restorative medicines and technologies currently available to the otolaryngologist. In large part this is attributable to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2147cf92dd1216fcc0bf1f79079155bb
https://pubmed.ncbi.nlm.nih.gov/28178538
https://pubmed.ncbi.nlm.nih.gov/28178538