Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Abraham M. Brown"'
Publikováno v:
Neurotrauma Reports, Vol 2, Iss 1, Pp 411-423 (2021)
Spinal cord contusion injury leads to Wallerian degeneration of axonal tracts, resulting in irreversible paralysis. Contusion injury causes perfusion loss by thrombosis and vasospasm, resulting in spinal cord ischemia. In several tissues, including h
Externí odkaz:
https://doaj.org/article/b3033e86f9894ff291afe1f71c981e5d
Autor:
Alexei M. Tyryshkin, Irina G. Stavrovskaya, Bruce S. Kristal, Sergei V. Baranov, Abraham M. Brown
Publikováno v:
Journal of Biological Chemistry. 283:665-676
Cytotoxicity associated with pathophysiological Ca(2+) overload (e.g. in stroke) appears mediated by an event termed the mitochondrial permeability transition (mPT). We built and solved a kinetic model of the mPT in populations of isolated rat liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4515ce22ee690af95b7ba1b6a257e870
https://doi.org/10.1074/jbc.m703484200
https://doi.org/10.1074/jbc.m703484200
Publikováno v:
Human Heredity. 61:97-103
Patients diagnosed with a standard clinical method (subject to misclassification error) are often combined with patients diagnosed with a gold-standard method (with zero or very small misclassification error) in family-based studies of complex diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8abc32c7bf3efa0cbacf6605dc179c2
https://doi.org/10.1159/000093303
https://doi.org/10.1159/000093303
Autor:
A. A. Zaspa, Boris F. Krasnikov, Igor V. Kulikov, Abraham M. Brown, Arthur J.L. Cooper, Dmitry B. Zorov, Yuri N. Antonenko, Bruce S. Kristal
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1708:375-392
Relationships among the multiple events that precede the mitochondrial membrane permeability transition (MPT) are not yet clearly understood. A combination of newly developed instrumental and computational approaches to this problem is described. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee801d876c472f7c67727233865e185
https://doi.org/10.1016/j.bbabio.2005.05.009
https://doi.org/10.1016/j.bbabio.2005.05.009
Autor:
Sergey Kazakov, Natalia L. Klyachko, Alexander V. Efimov, Abraham M. Brown, Valentina A. Shchedrina, Irina G. Gazaryan, Bruce S. Kristal
Publikováno v:
Journal of Biological Chemistry. 280:16106-16114
Cycling of intracellular pH has recently been shown to play a critical role in ischemia-reperfusion injury. Ischemia-reperfusion also leads to mitochondrial matrix acidification and dysfunction. However, the mechanism by which matrix acidification co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11bf6f0bc134084218fc46cadb9104ce
https://doi.org/10.1074/jbc.m414285200
https://doi.org/10.1074/jbc.m414285200
Autor:
Abraham M. Brown, Hsinhwa Lee, John P. Blass, Vahram Haroutunian, John Hardy, Derek Gordon, Michael Caudy
Publikováno v:
American Journal of Medical Genetics. :60-66
Abundant biochemical evidence links deficient activity of mitochondrial α-ketoglutarate dehydrogenase with neuropathologically confirmed Alzheimer's disease (AD). Reduced α-ketoglutarate dehydrogenase activity has also been associated with anti-mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b696b83ab96bdd305bba46fc31ba73
https://doi.org/10.1002/ajmg.b.30008
https://doi.org/10.1002/ajmg.b.30008
Autor:
Wenhua Zhang, Boris F. Krasnikov, Abraham M. Brown, Robert M. Friedlander, Bruce S. Kristal, M. Flint Beal, Jill Heemskerk, John P. Blass, Malini V. Narayanan, S. Stanley Young, Irina G. Stavrovskaya
Publikováno v:
The Journal of Experimental Medicine
Substantial evidence indicates that mitochondria are a major checkpoint in several pathways leading to neuronal cell death, but discerning critical propagation stages from downstream consequences has been difficult. The mitochondrial permeability tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc15e6c511d3beec490b50a8d5107c0
https://doi.org/10.1084/jem.20032053
https://doi.org/10.1084/jem.20032053
Autor:
John P. Blass, Michael Caudy, Hsinhwa Lee, Abraham M. Brown, Derek Gordon, Vahram Haroutunian
Publikováno v:
Neurochemical Research. 29:629-635
Association of the candidate gene DLST with late-onset Alzheimer's disease (LOAD) risk has been suggested on the basis of case-control studies. This gene, located on chromosome 14q24.3, encodes a subunit of a mitochondrial component known to be defec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ff75aba0345c8603190406654f863f
https://doi.org/10.1023/b:nere.0000014833.54481.1d
https://doi.org/10.1023/b:nere.0000014833.54481.1d
Autor:
Derek Gordon, Chad Haynes, Nancy R. Mendell, Abraham M. Brown, Vahram Haroutunian, Yaning Yang, Stephen J. Finch
Publikováno v:
Statistical Applications in Genetics and Molecular Biology. 3:1-32
Phenotype and/or genotype misclassification can: significantly increase type II error probabilities for genetic case/control association, causing decrease in statistical power; and produce inaccurate estimates of population frequency parameters. We p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa0fc3a27860ac78f032b28f6d19082
https://doi.org/10.2202/1544-6115.1085
https://doi.org/10.2202/1544-6115.1085
Autor:
William J. Burke, Bruce S. Kristal, Paul A Ulluci, Abraham M. Brown, Jinesh C. Jain, Shu Wen Li, Ann D. Conway
Publikováno v:
Free Radical Biology and Medicine. 30:924-931
Parkinson's disease (PD) is a major cause of age-related morbidity and mortality, present in nearly 1% of individuals at ages 70-79 and approximately 2.5% of individuals at age 85. L-DOPA (L-dihydroxyphenylalanine), which is metabolized to dopamine b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e08bbc16df7f3cc165aed9e6682878a
https://doi.org/10.1016/s0891-5849(01)00484-1
https://doi.org/10.1016/s0891-5849(01)00484-1