Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Abraham Kovoor"'
Autor:
J Christopher Octeau, Joseph M Schrader, Ikuo Masuho, Meenakshi Sharma, Christopher Aiudi, Ching-Kang Chen, Abraham Kovoor, Jeremy Celver
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105791 (2014)
G beta 5 (Gbeta5, Gβ5) is a unique G protein β subunit that is thought to be expressed as an obligate heterodimer with R7 regulator of G protein signaling (RGS) proteins instead of with G gamma (Gγ) subunits. We found that D2-dopamine receptor (D2
Externí odkaz:
https://doaj.org/article/57c65d263ef84be59288b515d21880a6
Autor:
Jeffrey L Waugh, Jeremy Celver, Meenakshi Sharma, Robert L Dufresne, Dimitra Terzi, S Craig Risch, William G Fairbrother, Rachael L Neve, John P Kane, Mary J Malloy, Clive R Pullinger, Harvest F Gu, Christos Tsatsanis, Steven P Hamilton, Stephen J Gold, Venetia Zachariou, Abraham Kovoor
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27984 (2011)
Regulator of G protein signaling 9-2 (RGS9-2) is a protein that is highly enriched in the striatum, a brain region that mediates motivation, movement and reward responses. We identified a naturally occurring 5 nucleotide deletion polymorphism in the
Externí odkaz:
https://doaj.org/article/540498c151d14f688ea36e5e43397dd0
Autor:
Craig M. Irving, Joseph Conti, Joseph M. Schrader, Joseph A. Christian, Timothy J. Aballo, J. Christopher Octeau, Dean J. Kareemo, Abraham Kovoor, Jonathan A. Javitch, Jodi L. Camberg, J. Robert Lane
Most clinically available antipsychotic drugs (APDs) bind dopamine D2 receptors (D2R) at therapeutic concentrations, and it is thought that they suppress psychotic symptoms by serving as competitive antagonists of dopamine at D2R. Here, we present da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671c676caedded477c208693fc2d86bf
https://europepmc.org/articles/PMC6462534/
https://europepmc.org/articles/PMC6462534/
Autor:
Chandra M Menendez, Jonathan Zuccolo, Sean Reim, Susan Swedo, Abraham Kovoor, Madeleine W Cunningham
Publikováno v:
The Journal of Immunology. 206:52.06-52.06
Neuropsychiatric diseases in autoimmune basal ganglia encephalitis (BGE) are associated with anti-neuronal autoantibodies which target the basal ganglia. BGE includes the group A streptococcal sequelae Sydenham chorea (SC) and pediatric autoimmune ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::627455e3f78253f478a77d5b579701d3
https://doi.org/10.4049/jimmunol.206.supp.52.06
https://doi.org/10.4049/jimmunol.206.supp.52.06
Autor:
Jeremy P. Clever, Abraham Kovoor, Grace Lincourt, Brenton DeBoef, Michael A. McGregor, Gregory R. Naumiec
Publikováno v:
Organic & Biomolecular Chemistry. 13:2537-2540
The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (Kd = 303 nM) is described. This molecular probe could be used for in vivo or in vitro studies of the DAT via MRI, PET or SPECT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850dc9ac0927d896eb6ad051b02eed46
https://doi.org/10.1039/c4ob02165g
https://doi.org/10.1039/c4ob02165g
Autor:
Amanda L C Chen, Rajendra D Badgaiyan, David Smith, Panayotis K. Thanos, Alphonso Kenison Roy, Edwin Chapman, Marcelo Febo, Edward J Modestino, Abraham Kovoor, Lyle Fried, Thomas J H Chen, Kenneth Blum, Kristina Dushaj, David Baron, Bruce Steinberg, Zsolt Demetrovics
Publikováno v:
Frontiers in bioscience (Elite edition). 10(1)
The interaction of neurotransmitters and genes that control the release of dopamine is the Brain Reward Cascade (BRC). Variations within the BRC, whether genetic or epigenetic, may predispose individuals to addictive behaviors and altered pain tolera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0b67b6d708f370d917a0932c7d1c6a
https://pubmed.ncbi.nlm.nih.gov/28930612
https://pubmed.ncbi.nlm.nih.gov/28930612
Publikováno v:
Journal of Biological Chemistry. 288:12554-12568
Plasma membrane microcompartments could allow different signaling pathways to operate more efficiently and prevent cross-talk. We utilized a novel in-cell biotin transfer assay to demonstrate that the majority of plasma membrane-expressed D2 dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb9943be55bf2078acffcb9e9d634a7
https://doi.org/10.1074/jbc.m112.443945
https://doi.org/10.1074/jbc.m112.443945
Autor:
Kerstin Brismar, Mohammed Seed Ahmed, Abraham Kovoor, Sofia Nordman, S. Efendic, Claes-Göran Östenson, Harvest F. Gu, Norhashimah Abu Seman, Tianwei Gu
Publikováno v:
Islets. 4:343-348
Adenylyl cyclase 3 (AC3) is expressed in pancreatic islets of the Goto-Kakizaki (GK) rat, a spontaneous animal model of type 2 diabetes (T2D), and also exerts genetic effects on the regulation of body weight in man. In addition to pancreatic islets,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67aa8e252ab44f33b84459d1747e571e
https://doi.org/10.4161/isl.22283
https://doi.org/10.4161/isl.22283
Publikováno v:
Journal of Neurochemistry. 120:56-69
J. Neurochem. (2012) 120, 56–69. Abstract Detergent-resistant membranes (DRM) are thought to contain structures such as lipid rafts that are involved in compartmentalizing cell membranes. We report that the majority of D2-dopamine receptors (D2R) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::019137e4eec55a8cf379179cfbff126c
https://doi.org/10.1111/j.1471-4159.2011.07559.x
https://doi.org/10.1111/j.1471-4159.2011.07559.x
Publikováno v:
Journal of Neurochemistry. 114:739-749
Regulator of G protein signaling 9-2 (RGS9-2), a member of the RGS family of GTPase accelerating proteins, is expressed specifically in the striatum, a brain region involved in controlling movement, motivation, mood and addiction. RGS9-2 can be found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a05406ce7105f5d8803100bac840ce5
https://doi.org/10.1111/j.1471-4159.2010.06805.x
https://doi.org/10.1111/j.1471-4159.2010.06805.x