Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Abraham K. Gebre"'
Autor:
Mingxia Liu, Cecilia Frej, Carl D. Langefeld, Jasmin Divers, Donald W. Bowden, J. Jeffrey Carr, Abraham K. Gebre, Jianzhao Xu, Benny Larsson, Björn Dahlbäck, Barry I. Freedman, John S. Parks
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 8, Pp 1425-1431 (2019)
apoM is a minor HDL apolipoprotein and carrier for sphingosine-1-phosphate (S1P). HDL apoM and S1P concentrations are inversely associated with atherosclerosis progression in rodents. We evaluated associations between plasma concentrations of S1P, pl
Externí odkaz:
https://doaj.org/article/796ea88d525e4e4a9bbbfc53943d9f5f
Autor:
Allison Weckerle, James A. Snipes, Dongmei Cheng, Abraham K. Gebre, Julie A. Reisz, Mariana Murea, Gregory S. Shelness, Gregory A. Hawkins, Cristina M. Furdui, Barry I. Freedman, John S. Parks, Lijun Ma
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 1, Pp 120-130 (2016)
APOL1 gene renal-risk variants are associated with nephropathy and CVD in African Americans; however, little is known about the circulating APOL1 variant proteins which reportedly bind to HDL. We examined whether APOL1 G1 and G2 renal-risk variant se
Externí odkaz:
https://doaj.org/article/c843542b63f14ce39b6c120e2cdb620b
Autor:
Xuewei Zhu, Soonkyu Chung, Xin Bi, Chia-Chi Chuang, Amanda L. Brown, Mingxia Liu, Jeongmin Seo, Helen Cuffe, Abraham K. Gebre, Elena Boudyguina, John S. Parks
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2708-2717 (2013)
Obesity-associated low-grade chronic inflammation plays an important role in the development of insulin resistance. The membrane lipid transporter ATP-binding cassette transporter A1 (ABCA1) promotes formation of nascent HDL particles. ABCA1 also dam
Externí odkaz:
https://doaj.org/article/8e7eb044fee143e58882d545debd80fb
Autor:
John S. Parks, Perry L. Colvin, Thomas L. Smith, Abraham K. Gebre, Elena Y. Boudyguina, Soonkyu Chung, Lolita M. Forrest, Christopher M. Lough
Publikováno v:
Nutrients, Vol 5, Iss 7, Pp 2629-2645 (2013)
Echium oil (EO), which is enriched in SDA (18:4 n-3), reduces plasma triglyceride (TG) concentrations in humans and mice. We compared mechanisms by which EO and fish oil (FO) reduce plasma TG concentrations in mildly hypertriglyceridemic male apoB100
Externí odkaz:
https://doaj.org/article/9bc4425229524a6f9b66f50ec868ded8
Autor:
Shunxing Rong, Qiang Cao, Mingxia Liu, Jeongmin Seo, Lin Jia, Elena Boudyguina, Abraham K. Gebre, Perry L. Colvin, Thomas L. Smith, Robert C. Murphy, Nilamadhab Mishra, John S. Parks
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 4, Pp 686-695 (2012)
12/15 lipoxygenase (12/15LO) oxidizes polyunsaturated fatty acids (PUFAs) to form bioactive lipid mediators. The role of 12/15LO in atherosclerosis development remains controversial. We evaluated atherosclerosis development and lipid metabolism in 12
Externí odkaz:
https://doaj.org/article/e01e069bb0fa4b40be7d94acf82a9726
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 729-742 (2010)
In Tangier disease, absence of ATP binding cassette transporter A1 (ABCA1) results in reduced plasma HDL and elevated triglyceride (TG) levels. We hypothesized that hepatocyte ABCA1 regulates VLDL TG secretion through nascent HDL production. Silencin
Externí odkaz:
https://doaj.org/article/1db1d55a872f488a85edcaad0fd9f1cf
Autor:
Anny Mulya, Jeongmin Seo, Amanda L. Brown, Abraham K. Gebre, Elena Boudyguina, Gregory S. Shelness, John S. Parks
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 3, Pp 514-524 (2010)
Apolipoprotein M (apoM) is a novel apolipoprotein that is reportedly necessary for preβ HDL formation; however, its detailed function remains unknown. We investigated the biogenesis and properties of apoM and its effects on the initial steps of nasc
Externí odkaz:
https://doaj.org/article/0e747f7234874826af81dc193d25e48c
Autor:
Anny Mulya, Ji-Young Lee, Abraham K. Gebre, Elena Y. Boudyguina, Soon-Kyu Chung, Thomas L. Smith, Perry L. Colvin, Xian-Cheng Jiang, John S. Parks
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 11, Pp 2390-2401 (2008)
We investigated the in vivo metabolic fate of pre-β HDL particles in human apolipoprotein A-I transgenic (hA-ITg) mice. Pre-β HDL tracers were assembled by incubation of [125I]tyramine cellobiose-labeled apolipoprotein A-I (apoA-I) with HEK293 cell
Externí odkaz:
https://doaj.org/article/ad73da9052dd4726b5be331eb8cf196a
Autor:
Lee Ji-Young, Robert M. Badeau, Mulya Anny, Boudyguina Elena, Abraham K. Gebre, Thomas L. Smith, John S. Parks
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 5, Pp 1052-1061 (2007)
Reduction of plasma LCAT activity has been observed in several conditions in which the size of HDL particles is increased; however, the mechanism of this reduction remains elusive. We investigated the plasma activity, mass, and in vivo catabolism of
Externí odkaz:
https://doaj.org/article/815738e2377840279a3a6cfc46762456
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 12, Pp 2310-2316 (2004)
We identified two regions of human LCAT (hLCAT) that when mutated separately to the corresponding rat sequence (E149A and Y292H/W294F) and transiently expressed in COS-1 cells increased phospholipase A2 (PLA2) activity by 5.5- and 2.8-fold, respectiv
Externí odkaz:
https://doaj.org/article/bf604f2a9fc64cf8837bc190f8a311b3