Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Abraham G, Eappen"'
Autor:
Peter F. Billingsley, Kasim I. George, Abraham G. Eappen, Robert A. Harrell, Robert Alford, Tao Li, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, David A. O’Brochta
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-12 (2021)
Abstract Background Plasmodium falciparum (Pf) sporozoites (PfSPZ) can be administered as a highly protective vaccine conferring the highest protection seen to date. Sanaria® PfSPZ vaccines are produced using aseptically reared Anopheles stephensi m
Externí odkaz:
https://doaj.org/article/e171d514987a4065ad10996b149acd97
Autor:
Eric R. James, Steve Matheny, James Overby, B. Kim Lee Sim, Abraham G. Eappen, Tao Li, Ming Lin Li, Thomas L. Richie, Sumana Chakravarty, Anusha Gunasekera, Tooba Murshedkar, Peter F. Billingsley, Stephen L. Hoffman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Ionizing radiation (UV, X-ray and ɣ) administered at an appropriate dose to pathogenic organisms can prevent replication while preserving metabolic activity. We have established the GMP process for attenuation by ionizing radiation of the Plasmodium
Externí odkaz:
https://doaj.org/article/f080f2a50f604070b6453d8d6f1822f5
Autor:
Ehud Inbar, Abraham G Eappen, Robert T Alford, William Reid, Robert A Harrell, Maryam Hosseini, Sumana Chakravarty, Tao Li, B Kim Lee Sim, Peter F Billingsley, Stephen L Hoffman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1009770 (2021)
PfSPZ Vaccine against malaria is composed of Plasmodium falciparum (Pf) sporozoites (SPZ) manufactured using aseptically reared Anopheles stephensi mosquitoes. Immune response genes of Anopheles mosquitoes such as Leucin-Rich protein (LRIM1), inhibit
Externí odkaz:
https://doaj.org/article/308e0a31ba9b42e891f589e7a62a24ba
Autor:
David A. O’Brochta, Robert Alford, Robert Harrell, Channa Aluvihare, Abraham G. Eappen, Tao Li, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Peter F. Billingsley
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparu
Externí odkaz:
https://doaj.org/article/d3a86d59c8da482d945d47306f4e8d71
Autor:
Gail E Potter, Betty Kim Lee Sim, Anusha Gunasekera, Stephen L. Hoffman, Tao Li, Thomas L. Richie, Matthew Adams, Anita Manoj, Christopher V. Plowe, Tooba Murshedkar, Matthew B. Laurens, Andrea A. Berry, Kirsten E. Lyke, Gregory A. Deye, Yonas Abebe, Biraj Shrestha, Jessie K. Kennedy, Abraham G. Eappen, Kathy A. Strauss, Mark A. Travassos
Publikováno v:
J Infect Dis
Direct venous inoculation of 3.2 × 103 aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8150d3c000859774c8f8451734002dc3
https://doi.org/10.1093/infdis/jiz410
https://doi.org/10.1093/infdis/jiz410
Autor:
Abraham G. Eappen, Tao Li, Meghan Marquette, Sumana Chakravarty, Natasha KC, Gigliola Zanghi, Benjamin U. Hoffman, Hashani Hettiarachchi, Asha Patil, Yonas Abebe, Christiane Tran, Alemtaye A. Yossef, Ian McWilliams, Robert D. Morrison, Ayyappan Rathakrishnan, Ehud Inbar, Ahmed S. I. Aly, Patricia De La Vega, Maria Belmonte, Martha Sedegah, Tint Wai, Joseph J. Campo, Harley King, Stefan H. I. Kappe, MingLin Li, Peter F. Billingsley, B. Kim Lee Sim, Stephen L. Hoffman
Publikováno v:
Nature.
An effective vaccine is needed for the prevention and elimination of malaria. The only immunogens that have been shown to have a protective efficacy of more than 90% against human malaria are Plasmodium falciparum (Pf) sporozoites (PfSPZ) manufacture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a94df8792667ad97121454dc0452cd4
https://pubmed.ncbi.nlm.nih.gov/36477528
https://pubmed.ncbi.nlm.nih.gov/36477528
Autor:
Kasim I. George, Peter F. Billingsley, Sumana Chakravarty, Abraham G. Eappen, Stephen L. Hoffman, Robert Alford, David A. O'Brochta, Tao Li, B. Kim Lee Sim, Robert A. Harrell
Publikováno v:
Malaria Journal
Malaria Journal, Vol 20, Iss 1, Pp 1-12 (2021)
Malaria Journal, Vol 20, Iss 1, Pp 1-12 (2021)
BackgroundPlasmodium falciparum(Pf) sporozoites (PfSPZ) can be administered as a highly protective vaccine conferring the highest protection seen to date. Sanaria® PfSPZ vaccines are produced using aseptically rearedAnopheles stephensimosquitoes. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3cbe6933df99593ea4acbe9348eee8
https://pubmed.ncbi.nlm.nih.gov/34174879
https://pubmed.ncbi.nlm.nih.gov/34174879
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62937 (2013)
Successful development of Plasmodium in the mosquito is essential for the transmission of malaria. A major bottleneck in parasite numbers occurs during midgut invasion, partly as a consequence of the complex interactions between the endogenous microb
Externí odkaz:
https://doaj.org/article/ad6c561216f24c3cbbe7cf0f6a1ec6ad
Autor:
Matthew B Laurens, Peter Billingsley, Adam Richman, Abraham G Eappen, Matthew Adams, Tao Li, Sumana Chakravarty, Anusha Gunasekera, Christopher G Jacob, B Kim Lee Sim, Robert Edelman, Christopher V Plowe, Stephen L Hoffman, Kirsten E Lyke
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68969 (2013)
Controlled human malaria infection (CHMI) is a powerful method for assessing the efficacy of anti-malaria vaccines and drugs targeting pre-erythrocytic and erythrocytic stages of the parasite. CHMI has heretofore required the bites of 5 Plasmodium fa
Externí odkaz:
https://doaj.org/article/1d6a599bd0e248e699f3289e20aa2ba1
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002965 (2012)
The mosquito is the obligate vector for malaria transmission. To complete its development within the mosquito, the malaria parasite Plasmodium must overcome the protective action of the mosquito innate immune system. Here we report on the involvement
Externí odkaz:
https://doaj.org/article/746c2005165b400da6c7edb555eb1351