Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Abraham Fong"'
Autor:
Sara A. Hurvitz, Jorge Chaves, Adam Brufsky, Alberto J. Montero, Bruno Fang, Kay Yeung, Manish R. Patel, Ritesh Parajuli, Adam Omidpanah, Elaina Gartner, Abraham Fong, Sophia Randolph, Funda Meric-Bernstam
Publikováno v:
Cancer Research. 82:OT1-14
Background: HER2-targeted therapies have led to marked improvements in survival for patients with HER2-positive breast cancer. Despite the gains obtained with current HER2-targeted therapies, an unmet medical need remains for patients with HER2-expre
Autor:
Erika Hamilton, Gini F. Fleming, Roisin E. O'Cearbhaill, Bilal Tariq, Dorothy French, Mihaela C. Cristea, David M. O'Malley, Kathleen N. Moore, Daniel Brickman, Abraham Fong, Michael Rossi
Publikováno v:
Gynecol Oncol
Objective Epithelial ovarian carcinoma (EOC) is diagnosed at advanced stage in the majority of women and, despite being initially chemosensitive, eventually recurs and develops resistance to known therapies. SC-003 is a pyrrolobenzodiazepine-based an
Autor:
Michael Rossi, Daniel Brickman, Mirella Lazarov, Melissa Lynne Johnson, Charles M. Rudin, Daniel Morgensztern, Abraham Fong
Publikováno v:
Lung Cancer
Objectives This phase 1 study investigated safety/tolerability, pharmacokinetics, and preliminary efficacy of SC-002, a delta-like ligand 3-directed antibody-drug conjugate, in advanced small cell lung cancer and large cell neuroendocrine carcinoma.
Autor:
Michael Rossi, Johanna C. Bendell, Susanna Varkey Ulahannan, Amit Mahipal, Andrea Cercek, Daniel Brickman, Katrina S. Pedersen, Abraham Fong
Publikováno v:
Cancer Research. 80:CT167-CT167
Background: Colorectal cancer (CRC) is the third most common cancer in the United States. Aberrant activation of the Wnt signaling pathway is associated with CRC progression. Ring finger protein 43 (RNF43) is a single-pass type 1 transmembrane protei
Autor:
Vivek Subbiah, Gini F. Fleming, Erika Hamilton, Daniel Brickman, Chris Chen, Premal H. Thaker, Kathleen N. Moore, Abraham Fong
Publikováno v:
Cancer Research. 80:CT124-CT124
Background: More than 90% of ovarian cancers are epithelial ovarian cancers (EOC), and approximately 70% of EOCs are serous histology. Despite advancements with the development of PARP inhibitors and incorporation of bevacizumab, a clear unmet need r
Publikováno v:
Journal of Biological Chemistry. 279:30099-30105
The processing of the nfκb2 gene product p100 to generate p52 is a regulated event, which is important for the instrumental function of NF-κB. We previously demonstrated that this tightly controlled event is regulated positively by NF-κB-inducing
Publikováno v:
Journal of Biological Chemistry. 277:40697-40702
Proteasome-mediated processing of the nfkappab2 gene product p100 is a regulated event that generates the NF-kappaB subunit p52. This event can be induced through p100 phosphorylation by a signaling pathway involving the nuclear factor-kappaB-inducin
Publikováno v:
Journal of Biological Chemistry. 276:40385-40388
The Tax oncoprotein encoded by human T-cell leukemia virus induces both T-cell activation and apoptosis. The mechanism by which Tax induces apoptosis has remained unclear. Using genetically manipulated T-cell lines, we demonstrate that Tax-induced T-
Autor:
Uwe Senftleben, Gutian Xiao, Florian R. Greten, Yi Chen, Gertraud Krähn, Michael Karin, Abraham Fong, Yinling Hu, Yixue Cao, Giuseppina Bonizzi, Shao Cong Sun
Publikováno v:
Science. 293:1495-1499
In mammals, the canonical nuclear factor kappaB (NF-kappaB) signaling pathway activated in response to infections is based on degradation of IkappaB inhibitors. This pathway depends on the IkappaB kinase (IKK), which contains two catalytic subunits,