Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Abraham F. L. Van Der Spek"'
Publikováno v:
Pediatric Radiology. 47:750-754
Image-guided biopsy techniques are widely used in clinical practice. Commonly used methods employ either ultrasound (US) or computed tomography (CT) for image guidance. In certain patients, US or CT guidance may be suboptimal, or even impossible, bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b89d4c57260053274ab0830e4761c52
https://doi.org/10.1007/s00247-017-3788-y
https://doi.org/10.1007/s00247-017-3788-y
Autor:
Thommey P. Thomas, Seok-Ki Choi, James R. Baker, Alina Kotlyar, Abraham F. L. Van Der Spek, Pascale Leroueil
Publikováno v:
The Journal of Physical Chemistry B. 116:10387-10397
Oximes are important in the treatment of organophosphate (OP) poisoning, but have limited biological half-lives. Complexing these drugs with a macromolecule, such as a dendrimer, could improve their pharmacokinetics. The present study investigates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1902eed029ec32141574bd4270ae1148
https://doi.org/10.1021/jp305867v
https://doi.org/10.1021/jp305867v
Autor:
Ming Hsin Li, Ankur Desai, Hong Zong, James R. Baker, Pascale Leroueil, Seok-Ki Choi, Abraham F. L. Van Der Spek
Publikováno v:
Macromolecules. 44:4026-4029
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2a877fc234c65139435c76c949505b
https://doi.org/10.1021/ma200522m
https://doi.org/10.1021/ma200522m
Autor:
Kevin K. Tremper, Paul E. Kazanjian, Abraham F. L. Van Der Spek, Michael O'Reilly, Sachin Kheterpal
Publikováno v:
Seminars in Anesthesia, Perioperative Medicine and Pain. 23:72-85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d769479893aa2639e74a8095ee28042
https://doi.org/10.1053/j.sane.2004.05.001
https://doi.org/10.1053/j.sane.2004.05.001
Autor:
Alina Kotlyar, Baohua Huang, Pascale R. Leroueil, Thommey P. Thomas, Mark Vartanian, James R. Baker, Ankur Desai, Hong Zong, Brent B. Ward, Abraham F. L. Van Der Spek, Xiangyang Shi, Xue-Min Cheng
Publikováno v:
Pharmaceutical research. 30(1)
Design and evaluate the in vitro and in vivo efficacy of two extended release morphine formulations developed for IV administration by complexing esterase activated morphine prodrugs to surface-modified, generation 5 (G5) poly(amidoamine) (PAMAM) den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29f0c6033ffea7abddf32e9247e35dc
https://pubmed.ncbi.nlm.nih.gov/23054086
https://pubmed.ncbi.nlm.nih.gov/23054086
Autor:
Abraham F. L. Van Der Spek, Thomas Dunham, Ankur Desai, Hong Zong, Xue-Min Cheng, Alina Kotlyar, Brent B. Ward, Baohua Huang, Pascale R. Leroueil, James R. Baker, Thommey P. Thomas
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(21)
Two morphine prodrugs (‘PDA’ and ‘PDB’) were synthesized and the kinetics of esterase-mediated morphine release from these prodrugs were determined when incubated with plasma from different animal species. Morphine was rapidly released from P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7098b91b4d9f4f3bc1de3197896875
https://pubmed.ncbi.nlm.nih.gov/20833544
https://pubmed.ncbi.nlm.nih.gov/20833544
Autor:
Alina Kotlyar, James R. Baker, Ankur Desai, Xue-Min Cheng, Baohua Huang, Shengzhuang Tang, Thommey P. Thomas, Abraham F. L. Van Der Spek
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
Hypoxia is known to occur in tissues in response to narcotic analgesic therapy using as a result of respiratory depression. The aim of this study was to synthesize a narcotic antagonist pro-drug that can be activated by tissue hypoxia to prevent the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b81725025a6ff06f21f7eb471365b5
https://pubmed.ncbi.nlm.nih.gov/19632838
https://pubmed.ncbi.nlm.nih.gov/19632838
Autor:
S. L. Primo-Parmo, Abraham F. L. Van Der Spek, Harold Lightstone, Bert N. La Du, Cynthia F. Bartels
Publikováno v:
Multidisciplinary Approaches to Cholinesterase Functions ISBN: 9781461363286
The silent phenotype of human butyrylcholinesterase (BChE; E.C. 3.1.1.8) is characterized by the absence or very low levels of enzyme activity. Heterogeneity of this phenotype was recognized soon after the first apparently homozygotes were identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39c6163e64acd42d9183dbd98f145385
https://doi.org/10.1007/978-1-4615-3046-6_8
https://doi.org/10.1007/978-1-4615-3046-6_8
Autor:
Seok Ki Choi, Pascale Leroueil, Ming-Hsin Li, Ankur Desai, Hong Zong, Abraham F. L. Van Der Spek, James R. Baker
Publikováno v:
Macromolecules; Jun2011, Vol. 44 Issue 11, p4026-4029, 4p
Publikováno v:
Anesthesiology. 64:812-814
2 cas chez lesquels des gouttes de neosynephrine conduisent a des modifications hemodynamiques, et ECG chez des malades anesthesies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb59c5bceeeb677c327b98b9a76dd28b
https://doi.org/10.1097/00000542-198606000-00026
https://doi.org/10.1097/00000542-198606000-00026