Age-Related Decrease in Abdominal Pain and Associated Structural- and Functional Mechanisms: An Exploratory Study in Healthy Individuals and Irritable Bowel Syndrome Patients

Autor: Abraham B. Beckers, Ellen Wilms, Zlatan Mujagic, Béla Kajtár, Kata Csekő, Zsa Zsa R. M. Weerts, Lisa Vork, Freddy J. Troost, Joanna W. Kruimel, José M. Conchillo, Zsuzsanna Helyes, Ad A. M. Masclee, Daniel Keszthelyi, Daisy M. A. E. Jonkers

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Introduction: The world population is ageing, resulting in increased prevalence of age-related comorbidities and healthcare costs. Limited data are available on intestinal health in elderly populations. Structural and functional changes, including al

Externí odkaz: https://doaj.org/article/4971bfc3e0a9427ab7eca00c4deac986

Comparing the efficacy of data-driven denoising methods for a multi-echo fMRI acquisition at 7T

Autor: Abraham B. Beckers, Benedikt A. Poser, Daniel Keszthelyi

In functional magnetic resonance imaging (fMRI) of the brain the signal is dominated by (physiological) noise. Imaging at ultrahigh field strength is becoming increasingly popular as it offers increased spatial accuracy. The latter is of particular b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::737a8ffadc4dec61c7c0371821e433b3
https://doi.org/10.1101/2022.07.03.498599

Digital Instruments for Reporting of Gastrointestinal Symptoms in Clinical Trials

Autor: Fabienne G M Smeets, Ad A.M. Masclee, Daniel Keszthelyi, Zsa Zsa R. M. Weerts, Johanna T. W. Snijkers, Abraham B. Beckers, Tim Klaassen, Lisa Vork

Publikováno v: JMIR Formative Research, 5(11):e31678. JMIR Publications Inc.
JMIR Formative Research

Background Questionnaires are necessary tools for assessing symptoms of disorders of the brain-gut interaction in clinical trials. We previously reported on the excellent adherence to a smartphone app used as symptom diary in a randomized clinical tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c22fff66e9b2e0c94eab58302229876
https://doi.org/10.2196/31678

Evidence for engagement of the nucleus of the solitary tract in processing intestinal chemonociceptive input irrespective of conscious pain response in healthy humans

Autor: Abraham B, Beckers, Lukas, van Oudenhove, Zsa Zsa R M, Weerts, Heidi I L, Jacobs, Nikos, Priovoulos, Benedikt A, Poser, Dimo, Ivanov, Ali, Gholamrezaei, Qasim, Aziz, Sigrid, Elsenbruch, Ad A M, Masclee, Daniel, Keszthelyi

Publikováno v: Pain. 163(8)

Neuroimaging studies have revealed important pathomechanisms related to disorders of brain-gut interactions, such as irritable bowel syndrome and functional dyspepsia. More detailed investigations aimed at neural processing in the brainstem, includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be980842af76d676d049c10ed2416e75
https://pubmed.ncbi.nlm.nih.gov/34799534

Colonoscopy is safe and not associated with higher pain scores in patients with hypermobility spectrum disorder: results from an exploratory prospective study

Autor: Rogier de Ridder, Lisa Vork, Abraham B. Beckers, Ad A.M. Masclee, Qasim Aziz, Daniel Keszthelyi, Asma Fikree

Publikováno v: Therapeutic Advances in Gastroenterology
Therapeutic Advances in Gastroenterology, Vol 13 (2020)
Therapeutic Advances in Gastroenterology, 13:1756284820927310. SAGE Publications Inc.

Background: Patient perception of colonoscopy varies greatly. Young slender women and patients with irritable bowel syndrome (IBS) appear to be at risk for periprocedural pain. Recent evidence suggests a high prevalence of joint hypermobility related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9d673973ee58c197043a0d0eeb6e9d
https://doi.org/10.1177/1756284820927310