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Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture

Autor: Gunduz Feyza, Aboulnasr Fatma M, Chandra Partha K, Hazari Sidhartha, Poat Bret, Baker Darren P, Balart Luis A, Dash Srikanta

Publikováno v: Virology Journal, Vol 9, Iss 1, p 143 (2012)

Abstract Background Hepatic steatosis is recognized as a major risk factor for liver disease progression and impaired response to interferon based therapy in chronic hepatitis C (CHC) patients. The mechanism of response to interferon-alpha (IFN-α) t

Externí odkaz: https://doaj.org/article/88eff9118e7a4bb1a090ef827fd8004b

Human Cancers Express TRAILshort, a Dominant Negative TRAIL Splice Variant, Which Impairs Immune Effector Cell Killing of Tumor Cells.

Autor: Aboulnasr F; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota., Krogman A; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota., Graham RP; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota., Cummins NW; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota., Misra A; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota., Garcia-Rivera E; Nference, Cambridge, Massachusetts., Anderson JR; Office of Translation to Practice, Mayo Clinic, Rochester, Minnesota., Natesampillai S; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota., Kogan N; Nference, Cambridge, Massachusetts., Aravamudan M; Nference, Cambridge, Massachusetts., Nie Z; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota., Chung TDY; Office of Translation to Practice, Mayo Clinic, Rochester, Minnesota., Buick R; Fusion Antibodies, Belfast, United Kingdom., Feldman AL; Division of Hematopathology, Mayo Clinic, Rochester, Minnesota., King RL; Division of Hematopathology, Mayo Clinic, Rochester, Minnesota., Novak AJ; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Ansell SM; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Kenderian S; Division of Hematology, Mayo Clinic, Rochester, Minnesota.; Department of Immunology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota., Badley AD; Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota. badley.andrew@mayo.edu.; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Nov 01; Vol. 26 (21), pp. 5759-5771. Date of Electronic Publication: 2020 Jul 15.