Výsledky vyhledávání - "Aboukameel Amro"

Akademický článek

I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma

Autor: Al-Katib Ayad, Arnold Alan A, Aboukameel Amro, Sosin Angela, Smith Peter, Mohamed Anwar N, Beck Frances W, Mohammad Ramzi M

Publikováno v: Molecular Cancer, Vol 9, Iss 1, p 228 (2010)

Abstract Background IKK-2 is an important regulator of the nuclear factor-κB (NF-κB) which has been implicated in survival, proliferation and apoptosis resistance of lymphoma cells. In this study, we investigated whether inhibition of IKK-2 impacts

Externí odkaz: https://doaj.org/article/c9ec62dd19ce42f4b52f675ac311c50d

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Akademický článek

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

Autor: Yang Dajun, Wu Sherwin, Sosin Angela, Aboukameel Amro, Azmi Asfar S, Wu Jack, Mohammad Ramzi M, Wang Shaomeng, Al-Katib Ayad M

Publikováno v: Molecular Cancer, Vol 8, Iss 1, p 115 (2009)

Abstract Background MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this study was to evaluate

Externí odkaz: https://doaj.org/article/81a58f5fbce244b69ec40a23e23173f1

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Akademický článek

SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status

Autor: Aboukameel Amro, Chen Ben, Azmi Asfar, Goustin Anton, Sun Yuan, Al-Katib Ayad M, Mohammad Ramzi M

Publikováno v: Journal of Hematology & Oncology, Vol 2, Iss 1, p 8 (2009)

Abstract The Bcl-2 family of proteins is critical to the life and death of malignant B-lymphocytes. Interfering with their activity using small-molecule inhibitors (SMI) is being explored as a new therapeutic strategy for treating B-cell tumors. We e

Externí odkaz: https://doaj.org/article/ee7268782bab4644ad164c2e861190ad

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Akademický článek

Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

Autor: Al-Katib Ayad, Wang Shaomeng, Yang Dajun, Chen Jianyong, Aboukameel Amro, Arnold Alan A, Mohammad Ramzi M

Publikováno v: Molecular Cancer, Vol 7, Iss 1, p 20 (2008)

Abstract Elevated expression of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL). This prompted us to evaluate a very potent non-peptidic Small-Molecule Inhibitor (SMI) targeting

Externí odkaz: https://doaj.org/article/7b02aea47f0c4316a8cda266db9f6c18

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