Antimicrobial Activity of Arthrospira platensis -Mediated Gold Nanoparticles against Streptococcus pneumoniae : A Metabolomic and Docking Study.

Autor: Azmy L; Department of Botany and Microbiology, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt., Al-Olayan E; Department of Zoology, College of Science, King Saud University, Riyadh 11472, Saudi Arabia., Abdelhamid MAA; Biology Department, Faculty of Education and Arts, Sohar University, Sohar 311, Oman.; Department of Biotechnology and Bioinformatics, Korea University, Sejong-Ro 2511, Sejong 30019, Republic of Korea., Zayed A; Department of Pharmacognosy, College of Pharmacy, Tanta University, Elguish Street (Medical Campus), Tanta 31527, Egypt., Gheda SF; Department of Botany, Faculty of Science, Tanta University, Tanta 31527, Egypt., Youssif KA; Department of Pharmacognosy, Faculty of Pharmacy, El Saleheya El Gadida University, Sharkia 44813, Egypt., Abou-Zied HA; Department of Medicinal Chemistry, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt., Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Ibraheem IBM; Department of Botany and Microbiology, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt., Pack SP; Department of Biotechnology and Bioinformatics, Korea University, Sejong-Ro 2511, Sejong 30019, Republic of Korea., Elsayed KNM; Department of Botany and Microbiology, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 19; Vol. 25 (18). Date of Electronic Publication: 2024 Sep 19.

Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF ^V600E inhibitors.

Autor: Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University Riyadh 11671 Saudi Arabia., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University Assiut 71526 Egypt bgyoussif2@gmail.com +20 10 9829 4419., Abou-Zied HA; Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University Minia Egypt., Bräse S; Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology 76131 Karlsruhe Germany braese@kit.edu., Brown AB; Florida Institute of Technology 150 W University Blvd Melbourne FL 32901 USA., Tawfeek HN; Chemistry Department, Faculty of Science, Minia University El Minia 61519 Egypt +20 10 6489 0489., El-Sheref EM; Chemistry Department, Faculty of Science, Minia University El Minia 61519 Egypt +20 10 6489 0489.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2024 Jun 24; Vol. 15 (7), pp. 2538-2552. Date of Electronic Publication: 2024 Jun 24 (Print Publication: 2024).

New pyrrolidine-carboxamide derivatives as dual antiproliferative EGFR/CDK2 inhibitors.

Autor: Frejat FOA; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, PR China.; Zhengzhou Key laboratory of new veterinary Drug preparation innovation, Zhengzhou, PR China., Zhao B; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, PR China., Furaijit N; School of pharmacy, Xi'an Jiaotong University, Xi'an, PR China., Wang L; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, PR China., Abou-Zied HA; Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt., Fathy HM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt., Mohamed FAM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences at Al-Qurayyat, Jouf University, Al-Qurayyat, Saudi Arabia.; Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Wu C; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou, PR China.; Zhengzhou Key laboratory of new veterinary Drug preparation innovation, Zhengzhou, PR China.; Henan Qunbo Pharmaceutical Research Institute Co. LTD., Zhengzhou, PR China.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2024 Jan; Vol. 103 (1), pp. e14422.

Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF ^V600E Inhibitory Pathways.

Autor: Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi Arabia., Abou-Zied HA; Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt., Hisham M; Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt., Beshr EAM; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Bräse S; Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany., Hayallah AM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Sphinx University, Assiut 71515, Egypt., Abdel-Aziz M; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Sep 12; Vol. 28 (18). Date of Electronic Publication: 2023 Sep 12.

Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAF ^V600E with promising antiproliferative properties.

Autor: Abou-Zied HA; Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt., Beshr EAM; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt., Gomaa HAM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia., Mostafa YA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Hayallah AM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Sphinx University, Assiut, Egypt., Abdel-Aziz M; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2023 Apr; Vol. 356 (4), pp. e2200464. Date of Electronic Publication: 2022 Dec 16.