Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Abood Okal"'
Autor:
Takafumi Koyama, Toshio Shimizu, Toshihiko Doi, Noboru Yamamoto, Shunsuke Kondo, Abood Okal, Aman Singh, Janet Markman, Takenori Akaike, Hideaki Kagehara, Yasutoshi Kuboki
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d22ff3409ffa9f8533a7158163ad970a
https://doi.org/10.1136/jitc-2022-sitc2022.0737
https://doi.org/10.1136/jitc-2022-sitc2022.0737
Autor:
Deepa Pookot, Scott Jacobson, John M. Ketcham, David Chian, Emily Karbarz, Dennis X. Hu, James Ross Walker, Gene Cutler, Ashkaan Younai, Mikhail Zibinsky, Raymond Diokno, David J. Wustrow, Betty Abraham, Angela Wadsworth, Maureen Kay Reilly, Cesar Meleza, Jenny McKinnell, Jeffrey J. Jackson, Abood Okal, Paul D. Kassner, Lisa A. Marshall, Oezcan Talay, Berenger Biannic, Bui Minna H T, Hilary Plake Beck, Hunter P. Shunatona, Omar Robles
Publikováno v:
Journal of Medicinal Chemistry. 62:6190-6213
Recruitment of suppressive CD4+ FOXP3+ regulatory T cells (Treg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human Treg express CCR4 and can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c664d1b35dae60b88d59898f44ef53
https://doi.org/10.1021/acs.jmedchem.9b00506
https://doi.org/10.1021/acs.jmedchem.9b00506
Autor:
Jeffrey J, Jackson, John M, Ketcham, Ashkaan, Younai, Betty, Abraham, Berenger, Biannic, Hilary P, Beck, Minna H T, Bui, David, Chian, Gene, Cutler, Raymond, Diokno, Dennis X, Hu, Scott, Jacobson, Emily, Karbarz, Paul D, Kassner, Lisa, Marshall, Jenny, McKinnell, Cesar, Meleza, Abood, Okal, Deepa, Pookot, Maureen K, Reilly, Omar, Robles, Hunter P, Shunatona, Oezcan, Talay, James R, Walker, Angela, Wadsworth, David J, Wustrow, Mikhail, Zibinsky
Publikováno v:
Journal of medicinal chemistry. 62(13)
Recruitment of suppressive CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85180faa74d36bfcafdd7b76884ccac3
https://pubmed.ncbi.nlm.nih.gov/31259550
https://pubmed.ncbi.nlm.nih.gov/31259550
Autor:
Mohamed E. Salama, Stephan J. Matissek, Karina J. Matissek, Abood Okal, Margit M. Janát-Amsbury, Robert Price, Carol S. Lim
Publikováno v:
Gene therapy
Inactivation of p53 pathway is reported in more than half of all human tumors and can be correlated to malignant development. Missense mutation in the DNA binding region (DBD) of p53 is the most common mechanism of p53 inactivation in cancer cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930143123a1a0af0835a51487bf3b6a2
https://doi.org/10.1038/gt.2014.70
https://doi.org/10.1038/gt.2014.70
Autor:
Sean P. Cornillie, Karina J. Matissek, Carol S. Lim, Stephan J. Matissek, Abood Okal, Thomas E. Cheatham
Publikováno v:
Molecular Pharmaceutics
The use of the tumor suppressor p53 for gene therapy of cancer is limited by the dominant negative inactivating effect of mutant endogenous p53 in cancer cells. We have shown previously that swapping the tetramerization domain (TD) of p53 with the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3034fd2bc552bee6a25a7357603e24
https://doi.org/10.1021/mp500202p
https://doi.org/10.1021/mp500202p
Autor:
Buvana Ravishankar, Lavanya Adusumilli, Deepa Pookot Pookot, Emily Huang, Raashi Sreenivasan, Lisa Marshall, Deepika Kaveri, Oezcan Talay, Silpa Suthram, Svetlana Miakicheva, Abood Okal, Mikhail Zibinsky, Jeffrey Jackson, Grant Shibuya, Paul Leger, Parcharee Tivitmahaisoon, Scott Jacobson, Steve Wong, Angela Wadsworth, Jerick Sanchez, Martin Brovarney, David Chian, Sachie Marubayashi, Aparna Jorapur, Delia Bradford, Christophe Colas, Gene Cutler, Jacob Schwartz, David Wustrow, Paul Kassner, Dirk Brockstedt
Publikováno v:
Cancer Research. 79:1104-1104
The tumor microenvironment (TME) is characterized by deficiencies in oxygen and key nutrients, such as glucose and amino acids, resulting in an overall immune-suppressive environment. Key suppressive cell types in the TME include tumor, stromal and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d03e198aa5e2aeba4468505e8d78367
https://doi.org/10.1158/1538-7445.am2019-1104
https://doi.org/10.1158/1538-7445.am2019-1104
Autor:
Aparna Jorapur, Lisa Marshall, Delia Bradford, Martin Brovarney, David Chian, Angela Wadsworth, Jerick Sanchez, Scott Jacobson, Emily Karbarz, Omar Robles, Ashkaan Younai, John Ketcham, Andrew Ng, Parcharee Tivitmahaisoon, Deepa Pookot, Sachie Marubayashi, Nathan Kozon, Christophe Colas, Abood Okal, Gene Cutler, David Wustrow, Jacob Schwarz, Oezcan Talay, Dirk Brockstedt, Brian Wong
Publikováno v:
The Journal of Immunology. 202:119.5-119.5
Type 2 helper T cells (Th2)cells have been shown to express CCR4 receptor, and play a critical role in driving the pathogenesis of asthma and atopic dermatitis. FLX193 is a best-in-class, highly-potent and selective small molecule CCR4 antagonist und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b4b879c724a97cf4ac0c8777a58428b
https://doi.org/10.4049/jimmunol.202.supp.119.5
https://doi.org/10.4049/jimmunol.202.supp.119.5
Autor:
Karina J. Matissek, Mohanad Mossalam, Andrew S. Dixon, Carol S. Lim, Abood Okal, Philip J. Moos
Publikováno v:
Molecular Pharmaceutics. 10:3922-3933
Because of the dominant negative effect of mutant p53, there has been limited success with wild-type (wt) p53 cancer gene therapy. Therefore, an alternative oligomerization domain for p53 was investigated to enhance the utility of p53 for gene therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ecf04827d4777be1260395114a3005
https://doi.org/10.1021/mp400379c
https://doi.org/10.1021/mp400379c
Publikováno v:
Molecular Pharmaceutics. 10:1350-1359
The tumor suppressor protein p53 induces apoptosis, cell cycle arrest, and DNA repair along with other functions in a transcription-dependent manner [Vousden, K. H. Cell 2000, 103(5), 691-694]. The selection of these functions depends on sequence-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61074e856f0b0969c4e165a748a7af51
https://doi.org/10.1021/mp300598k
https://doi.org/10.1021/mp300598k
Publikováno v:
Molecular Pharmaceutics. 9:1449-1458
Targeting the tumor suppressor p53 to the mitochondria triggers a rapid apoptotic response as efficiently as transcription-dependent p53. (1, 2) p53 forms a complex with the antiapoptotic Bcl-XL, which leads to Bak and Bax oligomerization resulting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf32e9e4fe45bc3c5f3f6daeb905ea4c
https://doi.org/10.1021/mp3000259
https://doi.org/10.1021/mp3000259