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Hyperspectral autofluorescence (AF) imaging of the retinal pigment epithelium (RPE) ex vivo in AMD

Autor: Smith, R. Theodore, Ablonczy, Z., Gerig, G., Hong, S., Tong, Y., Ami, T.B., Curcio, C., Ach, T.

Publikováno v: VI. International Symposium on AMD-Age-Related Macular Degeneration-Emerging Concepts-Exploring known and Identifying new Pathways; 20150911-20150912; Baden-Baden; DOC15amd34 /20151001/

Background: We have previously demonstrated that hyperspectral imaging is capable of extracting and localizing individual signals of abundant fluorophore families from normal RPE and Bruch’s-membrane (BrM) ex-vivo (Smith et al, Biomed Opt Express 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de24431879cb88625ed241d09705ec8d
http://www.egms.de/en/meetings/amd2015/15amd34.shtml

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Multimodal imaging of the retinal pigment epithelium and Bruch’s membrane to uncover molecular predictors of AMD

Autor: Ablonczy, Z, Bowrey, HE, Schey, KL, Crouch, RK

Background: Lipofuscin in the retinal pigment epithelium (RPE) and drusen deposits on Bruch’s membrane (BrM) are utilized to diagnose ocular aging and age-related macular degeneration (AMD). However, the molecules responsible for these signals and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b2b4f0550a530115d02d7fc40f0bb7

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As the bright light dims: loss of lipofuscin-attributable autofluorescence from RPE in aging and AMD

Autor: Ach, T, Smith, RT, Ablonczy, Z, Hillenkamp, J, Heintzmann, R, Sloan, KR, Curcio, CA

Background: In healthy persons, fundus autofluorescence (AF) intensity diminishes after age 70 [ref:1], with the underlying mechanisms still unknown. In age-related macular degeneration (AMD), hypoautofluorescent areas in fundus AF-imaging are often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6bfd1a6060bd75859d4e867b448859

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Quantitative Autofluoreszenz (AF)- und Zelldichte-Karten des humanen retinalen Pigmentepithels (RPE)

Autor: Ach, Thomas, Huisingh, C., McGwin, G., Messinger, J.D., Zhang, T., Bentley, M.J., Gutierrez, D.B., Ablonczy, Z., Smith, R.T., Sloan, K.R., Curcio, C.A.

Publikováno v: 27. Jahrestagung der Retinologischen Gesellschaft; 20140613-20140614; Düsseldorf; DOC14rg35 /20140612/

Hintergrund: Der Akkumulation von Lipofuszin wird eine zentrale Rolle in der Pathogenese der altersbedingten Makuladegeneration zugeschrieben. Allerdings existieren bis dato keine ausreichenden histologischen Daten zu AF und simultan ermittelter RPE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2b550f6b9676c8174ef6f951882cc3

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