Pulmonary delivery of siRNA-loaded lipid-polymer hybrid nanoparticles: Effect of nanoparticle size

Autor: Abishek Wadhwa, Thomas R. Bobak, Lennart Bohrmann, Reka Geczy, Sathiya Sekar, Gowtham Sathyanarayanan, Jörg P. Kutter, Henrik Franzyk, Camilla Foged, Katayoun Saatchi, Urs O. Häfeli

Publikováno v: OpenNano, Vol 13, Iss , Pp 100180- (2023)

Nanomedicines based on nanoparticles rely both on the potency of the drug as well as the efficiency of the delivery system, for which particle size plays a crucial role. For the intracellular delivery of small interference RNA (siRNA), lipid-polymer

Externí odkaz: https://doaj.org/article/a24eb0be3e2c4dbe91a0350992d611c3

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Autor: Abishek Wadhwa, Anas Aljabbari, Abhijeet Lokras, Camilla Foged, Aneesh Thakur

Publikováno v: Pharmaceutics, Vol 12, Iss 2, p 102 (2020)

In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies, t

Externí odkaz: https://doaj.org/article/0448043441a7465b892b92f6d65c2b5a

Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

Autor: Kaushik Thanki, Abishek Wadhwa, Henrik Franzyk, Camilla Foged, Aneesh Thakur, Abhijeet Lokras

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Lokras, A, Thakur, A, Wadhwa, A, Thanki, K, Franzyk, H & Foged, C 2020, ' Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles ', Frontiers in Bioengineering and Biotechnology, vol. 8, 601155 . https://doi.org/10.3389/fbioe.2020.601155
Frontiers in Bioengineering and Biotechnology

RNA interference (RNAi) has an unprecedented potential as a therapeutic strategy for reversibly silencing the expression of any gene. Therapeutic delivery of the RNAi mediator, i.e., small interfering RNA (siRNA), can be used to address diseases char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7fc72eaecd6903b9a181ca1c23e048

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

Autor: Abhijeet Lokras, Guillermo Cano-Garcia, Fabrice Rose, Henrik Franzyk, Kaushik Thanki, Cypriane Dormenval, Aneesh Thakur, Camilla Foged, Abishek Wadhwa

Publikováno v: Pharmaceutical research. 36(10)

Background With the recent approval of the first small interfering RNA (siRNA) therapeutic formulated as nanoparticles, there is increased incentive for establishing the factors of importance for the design of stable solid dosage forms of such comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599ad996a8632b1a802bda0a07fef335
https://pubmed.ncbi.nlm.nih.gov/31376020

EMERGING NOVEL NANOPHARMACEUTICALS FOR DRUG DELIVERY

Autor: Shaila A. Lewis, Vashish Mathura, Abishek Wadhwa

Publikováno v: Asian Journal of Pharmaceutical and Clinical Research. 11:35

Nanotechnology is an area of growing public interest. Employing nanotechnology in the field of drug delivery has led to the advent of nanopharmaceuticals. Nanopharmaceuticals are bound to surmount various obstacles that the field of pharmacy is curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4870cfe006f06fad443fbcfe10de790
https://doi.org/10.22159/ajpcr.2018.v11i7.25149