[THU0309] CLINICAL MANIFESTATIONS IN LATE VS EARLY –ONSET SYSTEMIC SCLEROSIS (SSC) G. Cuomo, M. Iudici, G. Abignano, G. Valentini. Second Universty of Naples, Rheumatology Unit, Naples, Italy Background: Differences have been so far pointed out in the clinical manifestations and disease course in patients with a number of autoimmune rheumatic diseases and different age at onset (1-3). Objectives: To investigate the occurrence of differences between early and late onset SSc. Methods: 260 SSc patients (233 females) with a median age at the onset of the disease of 40.5 years (range 8-74) were consecutively admitted to a tertiary centre from November 1st 2000 to October 31st 2008. They were divided into 2 groups: early onset (<40.5 years) and late onset (≥40.5 years). Differences in each of the epidemiological, clinical and serological aspects collected in all the patients at admission were analysed. Results: Table 1 lists the significant differences detected between the 2 groups. Early onset patients were found to have a longer disease duration at presentation, a higher prevalence of anti-Scl70 positivity and a higher prevalence of scleroderma renal crisis; a lower prevalence of antinucleolar antibody positivity; a lower percentage of pulmonary hypertension; a lower HAQ-DI and a lower prevalence of heart involvement. No difference was detected in clinical subset distribution. Late onset (138) Early onset (122) p Disease duration mean (sd) 6 (6) 10 (10) 0.003 Range (median) 0.5-26 (5) 0.5-45 (6) Serological subset Scl70 43 54 0.04 Nucleolar 9 23 0.004 PAPs ≥40mmHG (echocardiography) 14/124 3/119 0.01 HAQ-DI mean (sd) 0.65 (0.7) 0.5 (0.7) 0.037 Range (median) 0-0.275 (0.375) 0-0.25 (0.125) Severity scale Late onset (138) Early onset(122) p 0-1 2-3-4 0-1 2-3-4 Heart 117 21 121 1 <0.0001 Kidney 138 0 117 5 0.02 Conclusion: Our study demonstrate that similarly to systemic lupus erithematosus and rheumatoid arthritis, distinct differences related to age at onset also occur in SSc patients. References: • Calvo-Alen J. et al, Clin Rheumatol 2005 • Lalani S. et al, J Rheumatol 2010 • Ho CT et al, Ann Rheum 1998 Disclosure of Interest: None declared Citation: Ann Rheum Dis 2010;69(Suppl3):247 Session: Scleroderma, Myositis and related syndromes

Autor: CUOMO, Giovanna, Iudici, M., Abignano, G., Valentini, G.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::3dc27bfa3b2e2fd45059b30b16975a18
http://hdl.handle.net/11591/371418

Three‐dimensional nail imaging by optical coherence tomography: a novel biomarker of response to therapy for nail disease in psoriasis and psoriatic arthritis.

Autor: Abignano, G.^1,2,3 g.abignano@hotmail.com, Laws, P.⁴, Del Galdo, F.^1,2, Marzo‐Ortega, H.^1,2, McGonagle, D.^1,2

Publikováno v: Clinical & Experimental Dermatology. Jun2019, Vol. 44 Issue 4, p462-465. 4p. 2 Color Photographs, 3 Diagrams, 2 Charts.

Practice pattern for the use of intravenous iloprost for the treatment of peripheral vasculopathy in systemic sclerosis: A case-control study from the Italian national multicenter "SPRING" (Systemic Sclerosis Progression InvestiGation) Registry.

Autor: Riccieri V; Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Pellegrino G; Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.; Department of Rheumatology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy., Cipolletta E; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Giuggioli D; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Bajocchi G; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Bellando-Randone S; Department of Experimental and Clinical Medicine, Division of Rheumatology, AOUC, University of Florence, Florence, Italy., Dagna L; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milano, Italy., Zanframundo G; Department of Rheumatology, Policlinico San Matteo, Pavia, Italy., Foti R; Rheumatology Unit, A.O.U Policlinico S. Marco, Catania, Italy., Cacciapaglia F; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy., Cuomo G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Ariani A; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero Universitaria di Parma, Parma, Italy., Rosato E; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Lepri G; Department of Experimental and Clinical Medicine, Division of Rheumatology, AOUC, University of Florence, Florence, Italy., Girelli F; Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy., Zanatta E; Rheumatology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy., Bosello SL; Institute of Rheumatology and Affine Sciences, Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy., Cavazzana I; Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia and University of Brescia, Brescia, Italy., Ingegnoli F; Division of Clinical Rheumatology, ASST Pini, Department of Clinical Sciences & Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Research Center for Environmental Health, Università degli Studi di Milano, Milan, Italy., De Santis M; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy., Murdaca G; Department of Internal Medicine, University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Abignano G; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Romeo N; Rheumatology Unit, ASO Santa Croce e Carle, Cuneo, Italy., Della Rossa A; Department of Rheumatology, University of Pisa, Pisa, Italy., Caminiti M; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Iuliano A; Rheumatology Unit, San Camillo Forlanini Hospital, Rome, Italy., Ciano G; Hospital of Ariano Irpino, Local Health Department, Ariano Irpino, Italy., Beretta L; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy., Bagnato G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Lubrano E; Department of Rheumatology, University of Molise, Campobasso, Italy., De Andres I; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione 'Garibaldi,' Catania, Italy., Giollo A; Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy., Saracco M; Ospedale Mauriziano, Torino, Italy., Agnes C; San Lorenzo Hospital, Turin, Italy., Lumetti F; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Spinella A; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Magnani L; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Campochiaro C; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milano, Italy., De Luca G; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milano, Italy., Codullo V; Department of Rheumatology, Policlinico San Matteo, Pavia, Italy., Visalli E; Rheumatology Unit, A.O.U Policlinico S. Marco, Catania, Italy., Di Vico C; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Gigante A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Saccon F; Department of Medicine, Villa Salus Hospital, Venice, Italy., Grazia Lazzaroni M; Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia and University of Brescia, Brescia, Italy., Franceschini F; Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia and University of Brescia, Brescia, Italy., Generali E; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy., Mennillo G; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Barsotti S; Department of Rheumatology, University of Pisa, Pisa, Italy., Pagano Mariano G; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Calabrese F; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Furini F; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Vultaggio L; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Parisi S; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy., Peroni CL; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy., Bianchi G; Rheumatology Unit, Department of Musculoskeletal Sciences, Local Health Trust 3, La Colletta Hospital, Genoa, Italy., Conti F; Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Cozzi F; Department of Medicine, Villa Salus Hospital, Venice, Italy., D'Angelo S; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Doria A; Rheumatology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy., Fusaro E; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy., Govoni M; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Guiducci S; Department of Experimental and Clinical Medicine, Division of Rheumatology, AOUC, University of Florence, Florence, Italy., Iannone F; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy., Salvarani C; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Sebastiani GD; Rheumatology Unit, San Camillo Forlanini Hospital, Rome, Italy., Ferri C; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Matucci-Cerinic M; Department of Experimental and Clinical Medicine, Division of Rheumatology, AOUC, University of Florence, Florence, Italy., De Angelis R; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.

Publikováno v: Journal of scleroderma and related disorders [J Scleroderma Relat Disord] 2024 Feb; Vol. 9 (1), pp. 38-49. Date of Electronic Publication: 2024 Jan 11.

Impact of COVID-19 and vaccination campaign on 1,755 systemic sclerosis patients during first three years of pandemic. Possible risks for individuals with impaired immunoreactivity to vaccine, ongoing immunomodulating treatments, and disease-related lung involvement during the next pandemic phase.

Autor: Ferri C; Rheumatology Unit, University of Modena & RE., School of Medicine, Modena, Italy.; Rheumatology Clinic 'Madonna Dello Scoglio' Cotronei, Crotone, Italy., Raimondo V; Rheumatology Clinic 'Madonna Dello Scoglio' Cotronei, Crotone, Italy., Giuggioli D; Rheumatology Unit, University of Modena & RE., School of Medicine, Modena, Italy., Gragnani L; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy., Lorini S; MASVE Interdepartmental Hepatology Center, Department of Experimental and Clinical Medicine, University of Florence, Center for Research and Innovation CRIA-MASVE, AOU Careggi, Florence, Italy., Dagna L; Department of Ospedale S. Raffaele, Milano, Italy., Bosello SL; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy., Foti R; AOU Policlinico Vittorio Emanuele, Catania, Italy., Riccieri V; Rheumatology, Sapienza-University of Rome, Roma, Italy., Guiducci S; Rheumatology, University of Florence, Italy., Cuomo G; University of Campania, Luigi Vanvitelli, Napoli, Italy., Tavoni A; Clinical Immunology, University of Pisa, Pisa, Italy., De Angelis R; Rheumatology Clinic, Department of Clinical & Molecular Sciences, Marche Polytechnic University, Ancona, Italy., Cacciapaglia F; UO Reumatologia - DETO, Università di Bari, Bari, Italy., Zanatta E; Rheumatology, University of Padova, Padova, Italy., Cozzi F; Ospedale 'Villa Salus', Mestre, Italy., Murdaca G; Ospedale Policlinico S. Martino-University of Genova, Genova, Italy., Cavazzana I; Rheumatology, Spedali Civili di Brescia, Brescia, Italy., Romeo N; ASO S. Croce e Carle, Cuneo, Italy., Codullo V; Rheumatology, Policlinico San Matteo, Pavia, Italy., Pellegrini R; U.O.C. Medicina Interna 'M.Valentini' P.O, Annunziata, Cosenza, Italy., Varcasia G; U.O.S. Reumatologia, Ospedale Castrovillari, Cosenza, Italy., De Santis M; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Milan, Italy., Selmi C; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Milan, Italy., Abignano G; AOR San Carlo di Potenza, Potenza, Italy., Caminiti M; UOD Reumatologia- Grande Ospedale Metropolitano, Reggio Calabria, Italy., L'Andolina M; Rheumatology Outpatient Clinic, ASP- Vibo Valentia-Tropea Hospital, Italy., Olivo D; Rheumatology Outpatient Clinic, San Giovanni di Dio Hospital, Crotone, Italy., Lubrano E; Rheumatology, Università Del Molise, Campobasso, Italy., Spinella A; Rheumatology Unit, University of Modena & RE., School of Medicine, Modena, Italy., Lumetti F; Rheumatology Unit, University of Modena & RE., School of Medicine, Modena, Italy., De Luca G; Department of Ospedale S. Raffaele, Milano, Italy., Ruscitti P; Rheumatology Unit, Department of Biotechnological & Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Urraro T; Rheumatology Unit, 'M. Scarlato' Hospital, Scafati, Italy., Visentini M; Department of Translational and Precision Medicine, Sapienza University, Rome, Italy., Bellando-Randone S; Rheumatology, University of Florence, Italy., Visalli E; AOU Policlinico Vittorio Emanuele, Catania, Italy., Testa D; Clinical Immunology, University of Pisa, Pisa, Italy., Sciascia G; Clinical Immunology, University of Pisa, Pisa, Italy., Masini F; University of Campania, Luigi Vanvitelli, Napoli, Italy., Pellegrino G; Rheumatology, Sapienza-University of Rome, Roma, Italy., Saccon F; Rheumatology, University of Padova, Padova, Italy., Balestri E; Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy., Elia G; Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy., Ferrari SM; Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Pisa, Italy., Tonutti A; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Milan, Italy., Dall'Ara F; Child and Adolescent Neuropsychiatric Service (UONPIA) Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Pagano Mariano G; UOD Reumatologia- Grande Ospedale Metropolitano, Reggio Calabria, Italy., Pettiti G; ASO S. Croce e Carle, Cuneo, Italy., Zanframundo G; Rheumatology, Policlinico San Matteo, Pavia, Italy., Brittelli R; Rheumatology Clinic 'Madonna Dello Scoglio' Cotronei, Crotone, Italy., Aiello V; Rheumatology Clinic 'Madonna Dello Scoglio' Cotronei, Crotone, Italy., Dal Bosco Y; AOU Policlinico Vittorio Emanuele, Catania, Italy., Foti R; AOU Policlinico Vittorio Emanuele, Catania, Italy., Di Cola I; Rheumatology Unit, Department of Biotechnological & Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Scorpiniti D; Rheumatology Clinic 'Madonna Dello Scoglio' Cotronei, Crotone, Italy., Fusaro E; Rheumatology Unit, Azienda Ospedaliero Universitaria Città Della Salute e Della Scienza, Torino, Italy., Ferrari T; U.O.S. Reumatologia, Ospedale Castrovillari, Cosenza, Italy., Gigliotti P; U.O.T. Specialistica Ambulatoriale ASP 201, Cosenza, Italy., Campochiaro C; Department of Ospedale S. Raffaele, Milano, Italy., Francioso F; Rheumatology Clinic, Department of Clinical & Molecular Sciences, Marche Polytechnic University, Ancona, Italy., Iandoli C; University of Campania, Luigi Vanvitelli, Napoli, Italy., Caira V; U.O.S. Reumatologia, Ospedale Castrovillari, Cosenza, Italy., Zignego AL; MASVE Interdepartmental Hepatology Center, Department of Experimental and Clinical Medicine, University of Florence, Center for Research and Innovation CRIA-MASVE, AOU Careggi, Florence, Italy., D'Angelo S; AOR San Carlo di Potenza, Potenza, Italy., Franceschini F; Rheumatology, Spedali Civili di Brescia, Brescia, Italy., Matucci-Cerinic M; Rheumatology, University of Florence, Italy., Giacomelli R; Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Doria A; Rheumatology, University of Padova, Padova, Italy., Santini SA; Department of Basic, Clinical, Intensive and Perioperative Biotechnological Sciences, Catholic University School of Medicine, Rome, Italy.; Synlab Lazio, Roma, Italy., Fallahi P; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy., Iannone F; UO Reumatologia - DETO, Università di Bari, Bari, Italy., Antonelli A; Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.

Publikováno v: Journal of translational autoimmunity [J Transl Autoimmun] 2023 Oct 09; Vol. 7, pp. 100212. Date of Electronic Publication: 2023 Oct 09 (Print Publication: 2023).

Use of optical coherence tomography for the diagnosis of preclinical lesions of circumscribed palmar hypokeratosis.

Autor: Abignano, G.^1,2 g.abignano@hotmail.com, Kapadia, A.³, Lettieri, G.^1,2, Goodfield, M.⁴, Emery, P.^1,2, McGonagle, D.^1,2, Del Galdo, F.^1,2, Mikeljevic, J.³

Publikováno v: Clinical & Experimental Dermatology. Mar2017, Vol. 42 Issue 2, p192-195. 4p.