Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Abigail W Bigham"'
Autor:
Pontus K. Holmström, Taylor S. Harman, Anne Kalker, Bethany Steiner, Ella Hawkins, Kelsey C. Jorgensen, Kimberly T. Zhu, Ajaya J. Kunwar, Nilam Thakur, Sunil Dhungel, Nima Sherpa, Trevor A. Day, Erika K. Schagatay, Abigail W. Bigham, Tom D. Brutsaert
Publikováno v:
Experimental Physiology, Vol 109, Iss 4, Pp 535-548 (2024)
Abstract The human spleen contracts in response to stress‐induced catecholamine secretion, resulting in a temporary rise in haemoglobin concentration ([Hb]). Recent findings highlighted enhanced splenic response to exercise at high altitude in Sher
Externí odkaz:
https://doaj.org/article/188dfe92046541239d8dc055fbc678de
Autor:
Abigail W Bigham, Kati J Buckingham, Sofia Husain, Mary J Emond, Kathryn M Bofferding, Heidi Gildersleeve, Ann Rutherford, Natalia M Astakhova, Andrey A Perelygin, Michael P Busch, Kristy O Murray, James J Sejvar, Sharone Green, John Kriesel, Margo A Brinton, Michael Bamshad
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24745 (2011)
West Nile virus (WNV), a category B pathogen endemic in parts of Africa, Asia and Europe, emerged in North America in 1999, and spread rapidly across the continental U.S. Outcomes of infection with WNV range from asymptomatic to severe neuroinvasive
Externí odkaz:
https://doaj.org/article/3571f5782dba4ae1ba65a4328ef71a4e
Publikováno v:
Evolution: Education and Outreach, Vol 12, Iss 1, Pp 1-20 (2019)
Abstract In 1956, evolutionary biologist J.B.S. Haldane posed a question to anthropologists: “Are the biological differences between human groups comparable with those between groups of domestic animals such as greyhounds and bulldogs…?” It rea
Externí odkaz:
https://doaj.org/article/72972023e3f64e998a6f91fb2beeb3f2
Autor:
Ainash Childebayeva, Tamara R. Jones, Jaclyn M. Goodrich, Fabiola Leon-Velarde, Maria Rivera-Chira, Melisa Kiyamu, Tom D. Brutsaert, Dana C. Dolinoy, Abigail W. Bigham
Publikováno v:
Epigenetics, Vol 14, Iss 1, Pp 1-15 (2019)
Recent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain the extent of variation in
Externí odkaz:
https://doaj.org/article/a112cf0716624ca68ebef48ac3a631cd
Autor:
Ainash Childebayeva, Taylor Harman, Julien Weinstein, Jaclyn M. Goodrich, Dana C. Dolinoy, Trevor A. Day, Abigail W. Bigham, Tom D. Brutsaert
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Genetic and nongenetic factors are involved in the individual ability to physiologically acclimatize to high-altitude hypoxia through processes that include increased heart rate and ventilation. High-altitude acclimatization is thought to have a gene
Externí odkaz:
https://doaj.org/article/f5c27212468e49f6839ec4c0b50b5ae9
Autor:
Obed A Garcia, Kendall Arslanian, Daniel Whorf, Serena Thariath, Mark Shriver, Jun Z Li, Abigail W Bigham
Publikováno v:
Genome Biology and Evolution. 15
To characterize host risk factors for infectious disease in Mesoamerican populations, we interrogated 857,481 SNPs assayed using the Affymetrix 6.0 genotyping array for signatures of natural selection in immune response genes. We applied three statis
Publikováno v:
Human Genetics. 140:241-276
The suite of phenotypic diversity across geographically distributed human populations is the outcome of genetic drift, gene flow, and natural selection throughout human evolution. Human genetic variation underlying local biological adaptations to sel
Objectives: Potatoes are an important staple crop across the world and particularly in the Andes, where they were cultivated as early as 10,000 years ago. Ancient Andean populations that relied upon this high-starch food to survive could possess gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e9da3a935caea50007fcbcaff77b5c
https://hdl.handle.net/20.500.12866/12866
https://hdl.handle.net/20.500.12866/12866
Autor:
Ainash Childebayeva, Taylor Harman, Julien Weinstein, Trevor Day, Tom D. Brutsaert, Abigail W. Bigham
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology, Vol 12 (2021)
The individual physiological response to high-altitude hypoxia involves both genetic and non-genetic factors, including epigenetic modifications. Epigenetic changes in hypoxia factor pathway (HIF) genes are associated with high-altitude acclimatizati
Autor:
Jenna L Isherwood, Frank S. Lee, Tom D. Brutsaert, Melisa Kiyamu, Fabiola León-Velarde, Abigail W. Bigham, Sudipta Ghosh, Gianpietro Elias Revollendo, Maria Rivera-Ch
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 48
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Highland native Andeans have resided at altitude for millennia. They display high aerobic capacity (VO 2 max) at altitude, which may be a reflection of genetic adaptation to hypoxia. Previous genomewide (GW) scans for natural selection have nominated