Výsledky vyhledávání - "Abigail Vallejo"

Efficacy of the Piperidine Nitroxide 4-MethoxyTEMPO in Ameliorating Serum Amyloid A-Mediated Vascular Inflammation

Autor: Abigail Vallejo, Belal Chami, Gulfam Ahmad, Nathan Martin, Albaraa A. Mojadadi, Paul K. Witting

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 4549, p 4549 (2021)
Volume 22
Issue 9

Intracellular redox imbalance in endothelial cells (EC) can lead to endothelial dysfunction, which underpins cardiovascular diseases (CVD). The acute phase serum amyloid A (SAA) elicits inflammation through stimulating production of reactive oxygen s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177f3f7165ec3c9a983281d05ba79459
http://europepmc.org/articles/PMC8123591

Zobrazit plný text záznamu

NFkB Inhibition Mitigates Serum Amyloid A-Induced Pro-Atherogenic Responses in Endothelial Cells and Leukocyte Adhesion and Adverse Changes to Endothelium Function in Isolated Aorta

Autor: Nathan Martin, Belal Chami, Martin Simone, Waled A. Shihata, Joanne M. Dennis, Jaye P. F. Chin-Dusting, Judy B. de Haan, Gulfam Ahmad, Arpeeta Sharma, Paul K. Witting, Abigail Vallejo, Adrian I Abdo

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 1, p 105 (2018)
Volume 20
Issue 1

The acute phase protein serum amyloid A (SAA) is associated with endothelial dysfunction and early-stage atherogenesis. Stimulation of vascular cells with SAA increases gene expression of pro-inflammation cytokines and tissue factor (TF). Activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac4fec82ae8d767d931a68c2a739990
https://doi.org/10.20944/preprints201810.0766.v1

Zobrazit plný text záznamu

Role for neutrophil-derived myeloperoxidase in promoting acute colitis; inhibition of disease progression with 4-Methoxy TEMPO

Autor: Belal Chami, Abigail Vallejo, Nina Dickerhof, Joanne M. Dennis, Stephen Kum-Jew, Anthony J. Kettle, Paul K. Witting

Publikováno v: Free Radical Biology and Medicine. 120:S38

Inflammatory bowel disease (IBD) is a condition characterised by severe leukocyte recruitment to the colon. Leukocyte-myeloperoxidase (MPO)-derived oxidants may exacerbate colon injury in IBD. The nitroxide 4-MethoxyTEMPO (MetT) inhibits MPO activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2ef19a4d72594c30469eea77afa1406
https://doi.org/10.1016/j.freeradbiomed.2018.04.131

Zobrazit plný text záznamu

Inhibition of the Pro-Atherogenic Action of Serum Amyloid a (SAA) by Pharmacological Blockade of NFκB Pathway

Autor: Maryam Eghtedari, Belal Chami, Paul K. Witting, Nicola Barrie, Abigail Vallejo

Publikováno v: Free Radical Biology and Medicine. 100:S62-S63

The acute phase protein serum amyloid A (SAA) is a biomarker of inflammation. Elevated circulating SAA in chronic inflammatory disorders such as diabetes mellitus is associated with endothelial dysfunction and the earliest stages of atherosclerosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9faebed1974b883ccc6becc4eebe7d3
https://doi.org/10.1016/j.freeradbiomed.2016.10.164

Zobrazit plný text záznamu

4-Methoxy TEMPO Attenuates Murine Experimental Colitis

Autor: Abigail Vallejo, Gloria Jeong, Paul K. Witting, Adrina F. Varda, Belal Chami

Publikováno v: Free Radical Biology and Medicine. 100:S94-S95

Inflammatory bowel disease (IBD) is a chronic condition characterised by leukocyte recruitment to the gut mucosa, where MPO-mediated oxidative damage plays an important role in exacerbating tissue injury. Aim To test whether the MPO-inhibotor, 4-Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ca44081ca46d35e0bd36767960bc97d
https://doi.org/10.1016/j.freeradbiomed.2016.10.236

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání