Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Abigail Shelton"'
Autor:
Prachi Bajpai, Sumit Agarwal, Farrukh Afaq, Sameer Al Diffalha, Darshan S. Chandrashekar, Hyung-Gyoon Kim, Abigail Shelton, C. Ryan Miller, Santosh K. Singh, Rajesh Singh, Sooryanarayana Varambally, Ganji Purnachandra Nagaraju, Ashish Manne, Ravi Paluri, Moh’d Khushman, Upender Manne
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)
Abstract Background Treatment with regorafenib, a multiple-kinase inhibitor, to manage metastatic colorectal cancers (mCRCs) shows a modest improvement in overall survival but is associated with severe toxicities. Thus, to reduce regorafenib-induced
Externí odkaz:
https://doaj.org/article/0aee3c95ec79417fba66f7c7f7661819
Autor:
Xing Cheng, Jing An, Jitong Lou, Qisheng Gu, Weimin Ding, Gaith Nabil Droby, Yilin Wang, Chenghao Wang, Yanzhe Gao, Jay Ramanlal Anand, Abigail Shelton, Andrew Benson Satterlee, Breanna Mann, Yun-Chung Hsiao, Chih-Wei Liu, Kun Lu, Shawn Hingtgen, Jiguang Wang, Zhaoliang Liu, C. Ryan Miller, Di Wu, Cyrus Vaziri, Yang Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome maintenance mechanisms responsible
Externí odkaz:
https://doaj.org/article/30b03460503c40948e61ba53f8ff91ba
Autor:
Zainab Shonibare, Mehri Monavarian, Kathleen O’Connell, Diego Altomare, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D. Starr, Regina Whitaker, Andrew Berchuck, Andrew B. Nixon, Rebecca C. Arend, Nam Y. Lee, C. Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111066- (2022)
Summary: Growth factors in tumor environments are regulators of cell survival and metastasis. Here, we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin and their downstream SMAD effectors. Gene expression profilin
Externí odkaz:
https://doaj.org/article/20e1a0843b1f45028091a733956f68ac
Indigenous Languages and the Promise of Archives captures the energy and optimism that many feel about the future of community-based scholarship, which involves the collaboration of archives, scholars, and Native American communities. The American Ph
Autor:
Zainab Shonibare, Mehri Monavarian, Kathleen O’ Connell, Diego Altomare, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D. Starr, Regina Whitaker, Andrew Berchuck, Andrew B Nixon, Rebecca Arend, Nam Y Lee, C. Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
SummaryGrowth factors in the tumor environment are key regulators of cell survival and metastasis. Here we reveal, dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin, and their downstream SMAD effectors. Gene expression profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d79db4b8f8c92947d5cb0e48d046a7
https://doi.org/10.1101/2022.01.11.475900
https://doi.org/10.1101/2022.01.11.475900
Autor:
Benjamin Lin, Julia Ziebro, Kasey R. Skinner, Abigail Shelton, Erin Smithberger, Ryan Bash, Frank B. Furnari, Ryan Miller
Publikováno v:
Cancer Research. 82:1125-1125
Glioblastoma (GBM) is the most common malignant brain tumor in adults with a dismal 15-month median survival. Standard therapy consisting of surgical resection, radiation, and temozolomide has been unsuccessful in meaningfully extending survival and
Autor:
Zainab M. Shonibare, Mehri Monavarian, Kathleen O'Connell, Diego Altamore, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Andrew Berchuck, Andrew B. Nixon, Rebecca Arend, Nam Y. Lee, Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
Publikováno v:
Cancer Research. 82:107-107
The tumor ascites environment is enriched with cytokines and growth factors especially members of the Transforming Growth Factor-β (TGF-β) family, that play crucial roles in modulating anoikis sensitivity and consequently metastatic progression in
Autor:
Prachi Bajpai, Sumit Agarwal, Darshan S Chandrashekar, Amr Elkholy, Hyung Gyoon Kim, Farrukh Afaq, Santosh K Singh, Abigail Shelton, Ryan Bash, Rajesh Singh, Sooryanarayana Varambally, C Ryan Miller, Ravi Kumar Paluri, Moh'd M. Khushman, Sameer Al Diffalha, Upender Manne
Publikováno v:
Journal of Clinical Oncology. 40:e15597-e15597
e15597 Background: In the US, colorectal cancer (CRC) is the third most common cancer. Patients receiving regorafenib, a multiple-kinase inhibitor, recommended to manage metastatic CRCs (mCRCs), has a modest improvement in median overall survival but
Autor:
Gary L. Johnson, Ryan Bash, Abigail Shelton, Erin Smithberger, Michael P. East, Steven Angus, C. Ryan Miller, Frank B. Furnari, Madison Butler, Michael E. Berens, Allie Stamper
Publikováno v:
Neuro Oncol
Glioblastoma (GBM) is an aggressive primary brain tumor with poor survival and limited treatment options. However, it is an attractive candidate for precision therapeutic approaches due to the frequency of amplification and/or activating mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba47ea7bf08b0f9c3d807b6c74147983
https://europepmc.org/articles/PMC7650463/
https://europepmc.org/articles/PMC7650463/
Autor:
Frank B. Furnari, Steven P. Angus, Noah Sciaky, Ryan Miller, Abigail Shelton, Michael E. Berens, Madison Butler, Gary L. Johnson, Ryan E. Bash, Erin Smithberger, Alex Flores, Harshil Dhruv
Glioblastoma (GBM) has poor survival and lacks effective treatments. Due to frequent amplification and mutation of epidermal growth factor receptor (EGFR), several EGFR tyrosine kinase inhibitors have been trialed, but none have proven successful. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831542740a1cd67572994de62727c5a0
https://europepmc.org/articles/PMC6216460/
https://europepmc.org/articles/PMC6216460/