Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Abigail R. Solitro"'
Autor:
Stephanie L. Celano, Lisette P. Yco, Matthew G. Kortus, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Edward Spooner, Ronan C. O'Hagan, Peter Fuller, Katie R. Martin, Stuart D. Shumway, Jeffrey P. MacKeigan
Publikováno v:
iScience, Vol 15, Iss , Pp 109-118 (2019)
Summary: In cancer, autophagy is upregulated to promote cell survival and tumor growth during times of nutrient stress and can confer resistance to drug treatments. Several major signaling networks control autophagy induction, including the p53 tumor
Externí odkaz:
https://doaj.org/article/1963b7c4000c4a54a648f6f246f51215
Autor:
Katie R. Martin, Stephanie L. Celano, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Ronan C. O'Hagan, Stuart D. Shumway, Peter Fuller, Jeffrey P. MacKeigan
Publikováno v:
iScience, Vol 8, Iss , Pp 74-84 (2018)
Summary: In response to stress, cancer cells generate nutrients and energy through a cellular recycling process called autophagy, which can promote survival and tumor progression. Accordingly, autophagy inhibition has emerged as a potential cancer tr
Externí odkaz:
https://doaj.org/article/da31c51b36c548718b2b7aeb41c96998
Autor:
Ronan C. O'Hagan, Abigail R. Solitro, Mark E. Scott, Jeffrey P. MacKeigan, Stuart D. Shumway, Hakan Gunaydin, Katie R. Martin, Peter Fuller, Stephanie L. Celano
Publikováno v:
iScience
iScience, Vol 8, Iss, Pp 74-84 (2018)
iScience, Vol 8, Iss, Pp 74-84 (2018)
Summary In response to stress, cancer cells generate nutrients and energy through a cellular recycling process called autophagy, which can promote survival and tumor progression. Accordingly, autophagy inhibition has emerged as a potential cancer tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315b4a79e70b423e1a78cf0977eb2662
http://europepmc.org/articles/PMC6172447
http://europepmc.org/articles/PMC6172447
Hydroxychloroquine (HCQ) is a 4-aminoquinoline molecule used for the treatment of malaria, and more recently to treat rheumatoid arthritis, systemic lupus erythematosus, and cancer. In cancer, HCQ is being used in multiple cancer clinical trials as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f53bb6de5157719311e2f108f36af5c
https://doi.org/10.1101/496018
https://doi.org/10.1101/496018
Autor:
Mark E. Scott, Matthew G. Kortus, Edward Spooner, Ronan C. O'Hagan, Lisette P. Yco, Peter Fuller, Katie R. Martin, Stephanie L. Celano, Jeffrey P. MacKeigan, Stuart D. Shumway, Abigail R. Solitro, Hakan Gunaydin
Publikováno v:
iScience
iScience, Vol 15, Iss, Pp 109-118 (2019)
iScience, Vol 15, Iss, Pp 109-118 (2019)
Summary In cancer, autophagy is upregulated to promote cell survival and tumor growth during times of nutrient stress and can confer resistance to drug treatments. Several major signaling networks control autophagy induction, including the p53 tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58c128fd3d17c9b9e3ff8373d9ea684
https://pubmed.ncbi.nlm.nih.gov/31048145
https://pubmed.ncbi.nlm.nih.gov/31048145
Publikováno v:
Future Medicinal Chemistry
The search for a single silver bullet for the treatment of cancer has now been overshadowed by the identification of multiple therapeutic targets unique to each malignancy and even to each patient. In recent years, autophagy has emerged as one such t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b386dd138cb747fd1ed90e278d17177a
https://pubmed.ncbi.nlm.nih.gov/26689099
https://pubmed.ncbi.nlm.nih.gov/26689099
Publikováno v:
Molecular Cancer Therapeutics. 14:B08-B08
The discovery of cancer cells' dependency on the self-cannibalization program autophagy has spawned the investigation of its efficacy as a therapeutic target. However, the use of lysomotropic agents to inhibit autophagy as single-agent therapeutics h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1a55bcaf3ae8c0ba9e72aba4f591ed3
https://doi.org/10.1158/1538-8514.pi3k14-b08
https://doi.org/10.1158/1538-8514.pi3k14-b08