Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Abigail Pearce"'
Autor:
Abigail Pearce, Theo Redfern-Nichols, Matthew Harris, David R. Poyner, Mark Wigglesworth, Graham Ladds
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Signalling of the calcitonin-like receptor (CLR) is multifaceted, due to its interaction with receptor activity modifying proteins (RAMPs), and three endogenous peptide agonists. Previous studies have focused on the bias of G protein signalling media
Externí odkaz:
https://doaj.org/article/62f96b5f3c2843e0a635455b9b303c4f
Autor:
Dewi Safitri, Matthew Harris, Abigail Pearce, Xianglin Huang, Matthew Rosa, Kerry Barkan, Edward Wills, Maria Marti-Solano, Matthew D. Falk, Graham Ladds
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and are a common drug target. They can be stabilised in different conformational states by ligands to activate multiple transducers and effectors leading to a variet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b190e886edf3c9b677c806c5dd5adaa
https://doi.org/10.1101/2022.09.01.506210
https://doi.org/10.1101/2022.09.01.506210
Publikováno v:
Current Opinion in Endocrine and Metabolic Research. 16:28-36
The processes by which agonist binding promotes biological activity is a key issue in G protein-coupled receptor (GPCR) pharmacology, with much of our understanding governed by the application of mathematical models to experimental data. Models are b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dbb4aff59bf2f72a323c8661e9af0ae
https://doi.org/10.1016/j.coemr.2020.07.002
https://doi.org/10.1016/j.coemr.2020.07.002
Autor:
Junmin Peng, Graham Ladds, Manojkumar A. Puthenveedu, Amanda E. Mackenzie, Christian Munk, Matthew Harris, Xusheng Wang, Graeme Milligan, Tezz Quon, Stephanie E Crilly, M. Madan Babu, David E. Gloriam, Andrew B. Tobin, Maria Marti-Solano, Duccio Malinverni, Abigail Pearce
Publikováno v:
Nature
G protein-coupled receptors (GPCRs) are transmembrane proteins that modulate physiology across diverse tissues in response to extracellular signals. GPCR signalling can differ due to variation in the sequence (e.g. polymorphisms) or in the expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f813b5ad61b15e126f5fb5e2853cd8
https://pubmed.ncbi.nlm.nih.gov/33244189
https://pubmed.ncbi.nlm.nih.gov/33244189
Publikováno v:
Anaesthesia. 64:337-337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0366f4382149e689dfcd8822ef65c35e
https://doi.org/10.1111/j.1365-2044.2009.05883.x
https://doi.org/10.1111/j.1365-2044.2009.05883.x
Autor:
Abigail Pearce, Tonny Veenith
Publikováno v:
International Archives of Medicine, Vol 1, Iss 1, p 3 (2008)
International Archives of Medicine
International Archives of Medicine
Introduction Lactic acidosis often occurs in severely unwell patients presenting to Accident and Emergency. It is commonly associated with either hypoxia or decreased tissue perfusion secondary due to cardiovascular collapse or sepsis. Case presentat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bddd4ca7694bd931ab22fe942223a5
https://doi.org/10.1186/1755-7682-1-3
https://doi.org/10.1186/1755-7682-1-3