Poor Concordance among Nine Immunohistochemistry Classifiers of Cell-of-Origin for Diffuse Large B-Cell Lymphoma: Implications for Therapeutic Strategies

Autor: Andrew Wilson, José Cabeçadas, Andrew Owen, Abigail M. Lee, John G. Gribben, Maria Gomes da Silva, Andrew Clear, Janet Matthews, Maria Calaminici, Rute Alvarez, Rita Coutinho

Publikováno v: Clinical Cancer Research. 19:6686-6695

Purpose: The opportunity to improve therapeutic choices on the basis of molecular features of the tumor cells is on the horizon in diffuse large B-cell lymphoma (DLBCL). Agents such as bortezomib exhibit selective activity against the poor outcome ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a56400ae77ed82c845b31a0a11424a
https://doi.org/10.1158/1078-0432.ccr-13-1482

Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells

Autor: Sameena Iqbal, John G. Gribben, Maria Calaminici, Paul Greaves, Abigail M. Lee, Andrew Wilson, Janet Matthews, Andrew Clear, Andrew Owen

Publikováno v: Blood. 122:2856-2863

CD4(+) T-helper cells (THs) dominate the classical Hodgkin lymphoma (CHL) microenvironment, but their role is poorly understood. Advances in flow cytometry and immunohistochemistry permit more detailed investigation of this aspect of CHL pathophysiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b025997d0a9c968d6a771cdb7a2463
https://doi.org/10.1182/blood-2013-06-508044

Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment

Autor: Kelly J. Morris, Alan G. Ramsay, Andrew Clear, Maria Calaminici, Finlay MacDougall, Abigail M. Lee, Gavin Kelly, T. Andrew Lister, John G. Gribben, Simon Hallam

Publikováno v: Blood. 115:5053-5056

Follicular lymphoma has considerable clinical heterogeneity, and there is a need for easily quantifiable prognostic biomarkers. Microvessel density has been shown to be a useful prognostic factor based on numerical assessment of vessel numbers within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f311b05f359d404d22cea38864e589
https://doi.org/10.1182/blood-2009-11-253260

Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications (a study from the Lunenburg Lymphoma Biomarker Consortium)

Autor: Abigail M. Lee, Andreas Rosenwald, Sandra J. Horning, Gilles Salles, Wolfram Klapper, Randy D. Gascoyne, Anton Hagenbeek, Birgitta Sander, Andrew Lister, Christoph Thorns, Wanling Xie, John M. M. Raemaekers, Thierry Jo Molina, Daphne de Jong, Philippe Gaulard, Edie Weller, Elias Campo, Mukesh Chhanabhai

Publikováno v: de Jong, D, Rosenwald, A, Chhanabhai, M, Gaulard, P, Klapper, W, Lee, A, Sander, B, Thorns, C, Campo, E, Molina, T, Norton, A, Hagenbeek, A, Horning, S, Lister, A, Raemaekers, J, Gascoyne, R D, Salles, G, Weller, E & Lunenburg Lymphoma Biomarker Consortium 2007, ' Immunohistochemical prognostic markers in diffuse large B-cell lymphoma : validation of tissue microarray as a prerequisite for broad clinical applications--a study from the Lunenburg Lymphoma Biomarker Consortium ', Journal of Clinical Oncology, vol. 25, no. 7, pp. 805-12 . https://doi.org/10.1200/JCO.2006.09.4490
Journal of clinical pathology, 62(2), 128-138. BMJ Publishing Group
Journal of Clinical Oncology, 25(7), 805-12. American Society of Clinical Oncology
Journal of Clinical Pathology : the Journal of the Association of Clinical Pathologists, 62, 128-38
Journal of Clinical Pathology : the Journal of the Association of Clinical Pathologists, 62, 2, pp. 128-38
Journal of Clinical Oncology, 25, 7, pp. 805-12
Journal of Clinical Oncology, 25, 805-12
Journal of Clinical Pathology, 62(2), 128-38. BMJ Publishing Group
Journal of clinical oncology, 25(7), 805-812. American Society of Clinical Oncology
de Jong, D, Xie, W, Rosenwald, A, Chhanabhai, M, Gaulard, P, Klapper, W, Lee, A, Sander, B, Thorns, C, Campo, E, Molina, T, Hagenbeek, A, Horning, S, Lister, A, Raemaekers, J, Salles, G, Gascoyne, R D & Weller, E 2009, ' Immunohistochemical prognostic markers in diffuse large B-cell lymphoma : validation of tissue microarray as a prerequisite for broad clinical applications (a study from the Lunenburg Lymphoma Biomarker Consortium) ', Journal of Clinical Pathology, vol. 62, no. 2, pp. 128-38 . https://doi.org/10.1136/jcp.2008.057257

PurposeThe results of immunohistochemical class prediction and prognostic stratification of diffuse large B-cell lymphoma (DLBCL) have been remarkably various thus far. Apart from biologic variations, this may be caused by differences in laboratory t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500c6a28776deb58ea913ac124c15642
https://doi.org/10.1136/jcp.2008.057257

Number of CD4+ Cells and Location of Forkhead Box Protein P3–Positive Cells in Diagnostic Follicular Lymphoma Tissue Microarrays Correlates With Outcome

Autor: T. Andrew Lister, Andrew Norton, Abigail M. Lee, Maria Calaminici, Finlay MacDougall, John G. Gribben, Andrew Clear, Janet Matthews, Suzanne Jordan, Lindsey K. Goff, Andrew Davies

Publikováno v: Journal of Clinical Oncology. 24:5052-5059

Purpose To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance. Patients and Methods Immunohistochemistry was used to study numbers and location of cells staining positive for i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5c6b538c56567a1fd6559d5306f2ed
https://doi.org/10.1200/jco.2006.06.4642