Výsledky vyhledávání - "Abigail Lukowicz"

Akademický článek

Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice

Autor: Wenhui Qu, Andrea Johnson, Joo Hyun Kim, Abigail Lukowicz, Daniel Svedberg, Marija Cvetanovic

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-11 (2017)

Abstract Background Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar neurodegeneration, and

Externí odkaz: https://doaj.org/article/e6e0d051f5c24c6db0fbb361a15e5c6e

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Akademický článek

Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1.

Autor: Austin Ferro, Wenhui Qu, Abigail Lukowicz, Daniel Svedberg, Andrea Johnson, Marija Cvetanovic

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200013 (2018)

Spinocerebellar Ataxia type 1 (SCA1) is a fatal neurodegenerative genetic disease that is characterized by pronounced neuronal loss and gliosis in the cerebellum. We have previously demonstrated microglial activation, measured as an increase in micro

Externí odkaz: https://doaj.org/article/397ce78738144359a69f400714dec88d

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Astroglia contribute to the pathogenesis of spinocerebellar ataxia type 1 (SCA1) in a biphasic, stage-of-disease specific manner

Autor: Andrea Johnson, Joo Hyun Kim, Wenhui Qu, Abigail Lukowicz, Marija Cvetanovic

Publikováno v: Glia

Spinocerebellar ataxia type 1 (SCA1) is a fatal, dominantly inherited neurodegenerative disease caused by the expansion of CAG repeats in the Ataxin-1 (ATXN1) gene. SCA1 is characterized by balance and coordination deficits due to the predominant los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7d237888160aad4624516dd60150d3
https://europepmc.org/articles/PMC8049102/

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Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1

Autor: Andrea Johnson, Marija Cvetanovic, Abigail Lukowicz, Wenhui Qu, Austin Ferro, Daniel Svedberg

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200013 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5350ee3f1483f917f44152d071ff6d3d
https://pubmed.ncbi.nlm.nih.gov/29975753

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Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice

Autor: Daniel Svedberg, Andrea Johnson, Joo Hyun Kim, Marija Cvetanovic, Abigail Lukowicz, Wenhui Qu

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-11 (2017)

Background Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar neurodegeneration, and gliosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf186d7d97f9707ea33aeac324253c
https://pubmed.ncbi.nlm.nih.gov/28545543

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