Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Abigail L. Shearin"'
Publikováno v:
Molecular Metabolism, Vol 5, Iss 7, Pp 472-479 (2016)
Objective: Adipose depot mass is tightly regulated to maintain energy homeostasis. AKT is a critical kinase in the insulin-signaling cascade that is required for the process of adipogenesis in vitro. However, the role of AKT in the maintenance and/or
Externí odkaz:
https://doaj.org/article/53077c18c5c14f349703017f9efffff5
Autor:
Elaine A. Ostrander, Heidi G. Parker, Catherine André, Gerard R. Rutteman, Matthew Breen, Francis Galibert, Mary Lynch, Danielle M. Karyadi, Maud Rimbault, Patrick Devauchelle, Andrea Gröne, Erika M. Kwon, Jerome Abadie, John Cullen, Daniel L. Faden, Emmett V. Schmidt, Suzanne A. Erich, Edouard Cadieu, Benoit Hedan, Abigail L. Shearin
Background: Advantages offered by canine population substructure, combined with clinical presentations similar to human disorders, makes the dog an attractive system for studies of cancer genetics. Cancers that have been difficult to study in human f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2702bc74d1a03c07b6fd41f88c6ca412
https://doi.org/10.1158/1055-9965.c.6515439
https://doi.org/10.1158/1055-9965.c.6515439
Autor:
Elaine A. Ostrander, Heidi G. Parker, Catherine André, Gerard R. Rutteman, Matthew Breen, Francis Galibert, Mary Lynch, Danielle M. Karyadi, Maud Rimbault, Patrick Devauchelle, Andrea Gröne, Erika M. Kwon, Jerome Abadie, John Cullen, Daniel L. Faden, Emmett V. Schmidt, Suzanne A. Erich, Edouard Cadieu, Benoit Hedan, Abigail L. Shearin
PDF file - 493K, The MTAP-CDKN2A Locus Confers Susceptibility to Cancer in a Naturally Occurring Canine Model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb667d2cc47081b859cf6cebf5b1384b
https://doi.org/10.1158/1055-9965.22436502.v1
https://doi.org/10.1158/1055-9965.22436502.v1
Autor:
Abigail L Shearin, Elaine A Ostrander
Publikováno v:
PLoS Biology, Vol 8, Iss 3, p e1000310 (2010)
Externí odkaz:
https://doaj.org/article/5ca79dd239254d7d815b58cc84a0d427
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 7, Pp 472-479 (2016)
Molecular Metabolism, Vol 5, Iss 7, Pp 472-479 (2016)
Objective Adipose depot mass is tightly regulated to maintain energy homeostasis. AKT is a critical kinase in the insulin-signaling cascade that is required for the process of adipogenesis in vitro. However, the role of AKT in the maintenance and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d4fff8242a86acd305f67e906d03bf
http://europepmc.org/articles/PMC4921941
http://europepmc.org/articles/PMC4921941
Autor:
Bob R. Monks, Abigail L. Shearin, Matthew J. Emmett, Qingwei Chu, Lisa M. DiPilato, Morris J. Birnbaum, Shlomit Koren
Publikováno v:
Diabetologia. 58:1063-1070
The release of fatty acids from adipocytes, i.e. lipolysis, is maintained under tight control, primarily by the opposing actions of catecholamines and insulin. A widely accepted model is that insulin antagonises catecholamine-dependent lipolysis thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483bf8a679b671dbedf9a66e0c168703
https://doi.org/10.1007/s00125-015-3532-9
https://doi.org/10.1007/s00125-015-3532-9
Publikováno v:
Clinical Cancer Research. 24:IA08-IA08
Histiocytic sarcoma (HS) is a rare human hematopoietic neoplasm that accounts for less than 1% of hematolymphoid cancers and occurs either concurrently with or subsequently to B- or T-lymphoblastic lymphoma and other B-cell cancers. As such, its gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c06e62dc896b6da4c5946f2c4a4431
https://doi.org/10.1158/1557-3265.sarcomas17-ia08
https://doi.org/10.1158/1557-3265.sarcomas17-ia08
Publikováno v:
Disease Models & Mechanisms. 3:27-34
In recent years Canis familiaris, the domestic dog, has drawn considerable attention as a system in which to investigate the genetics of disease susceptibility, morphology and behavior. Because dogs show remarkable intrabreed homogeneity, coupled wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417bfe5ff62e91ad74ea0ae8b1a6c992
https://doi.org/10.1242/dmm.004358
https://doi.org/10.1242/dmm.004358
Publikováno v:
Annual review of genetics. 44
In the last five years, canine genetics has gone from map construction to complex disease deconstruction. The availability of a draft canine genome sequence, dense marker chips, and an understanding of the genome architecture has changed the types of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5e26f0a02318b4f6d83dfc2c266807
https://pubmed.ncbi.nlm.nih.gov/21047261
https://pubmed.ncbi.nlm.nih.gov/21047261
Autor:
Matthew Breen, Cathryn S. Mellersh, Abigail L. Shearin, Elaine A. Ostrander, Emmett V. Schmidt, Heidi G. Parker
Publikováno v:
Cancer Research. 70:4745-4745
Histiocytic sarcoma (HS) is a cancer characterized by unregulated proliferation of histiocytes. In the flat-coated retriever (FCR), the primary tumor site is frequently appendicular with a high rate of local and distant metastases. The disease occurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::725c717400870bf474525fc4e7478386
https://doi.org/10.1158/1538-7445.am10-4745
https://doi.org/10.1158/1538-7445.am10-4745