Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Abigail L. LaBella"'
Autor:
Pol Solé-Navais, Julius Juodakis, Karin Ytterberg, Xiaoping Wu, Jonathan P. Bradfield, Marc Vaudel, Abigail L. LaBella, Øyvind Helgeland, Christopher Flatley, Frank Geller, Moshe Finel, Mengqi Zhao, Philip Lazarus, Hakon Hakonarson, Per Magnus, Ole A. Andreassen, Pål R. Njølstad, Struan F. A. Grant, Bjarke Feenstra, Louis J. Muglia, Stefan Johansson, Ge Zhang, Bo Jacobsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Jaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates experience more sev
Externí odkaz:
https://doaj.org/article/e3ef70ee8fd04fcf9bd96a050dcd355b
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionEukaryotic life depends on the functional elements encoded by both the nuclear genome and organellar genomes, such as those contained within the mitochondria. The content, size, and structure of the mitochondrial genome varies across orga
Externí odkaz:
https://doaj.org/article/e679e5f3a59c4d5aa832bc6d963a8be1
Autor:
Abigail L. LaBella, Abin Abraham, Yakov Pichkar, Sarah L. Fong, Ge Zhang, Louis J. Muglia, Patrick Abbot, Antonis Rokas, John A. Capra
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
There is a need for analytical frameworks to investigate the evolution of complex genetic traits. Here, the authors develop an approach to simultaneously evaluate different evolutionary signatures on trait-associated genetic variants for complex trai
Externí odkaz:
https://doaj.org/article/c07ea25152944d9985c310b525f3f635
Autor:
Jacob L. Steenwyk, Matthew E. Mead, Patrícia Alves de Castro, Clara Valero, André Damasio, Renato A. C. dos Santos, Abigail L. Labella, Yuanning Li, Sonja L. Knowles, Huzefa A. Raja, Nicholas H. Oberlies, Xiaofan Zhou, Oliver A. Cornely, Frieder Fuchs, Philipp Koehler, Gustavo H. Goldman, Antonis Rokas
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT The ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), first described in Wuhan, China. A subset of COVID-19 patients has been reported t
Externí odkaz:
https://doaj.org/article/942bab531dd244b297e53bf7fe530adc
Publikováno v:
Bioinformatics. 39
Summary GSEL is a computational framework for calculating the enrichment of signatures of diverse evolutionary forces in a set of genomic regions. GSEL can flexibly integrate any sequence-based evolutionary metric and analyze sets of human genomic re
Autor:
Ana Cristina Colabardini, Norman Van Rhijn, Abigail L. LaBella, Clara Valero, Lauren Dineen, Antonis Rokas, Gustavo H. Goldman
Publikováno v:
Antimicrob Agents Chemother
Aspergillus fumigatus is the main etiological agent of aspergillosis. The antifungal drug caspofungin (CSP) can be used against A. fumigatus, and CSP tolerance is observed. We have previously shown that the transcription factor FhdA is important for
The fungal genus Aspergillus contains a diversity of species divided into taxonomic sections of closely related species. Section Flavi contains 33 species, many of industrial, agricultural, or medical relevance. Here, we analyze the mitochondrial gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f4e12867dedecf22eacee5398d96efe
https://doi.org/10.1101/2022.08.23.505037
https://doi.org/10.1101/2022.08.23.505037
Autor:
Yuanning Li, Hongyue Liu, Jacob L. Steenwyk, Abigail L. LaBella, Marie-Claire Harrison, Marizeth Groenewald, Xiaofan Zhou, Xing-Xing Shen, Tao Zhao, Chris Todd Hittinger, Antonis Rokas
Publikováno v:
Current biology : CB.
Examination of the changes in order and arrangement of homologous genes is key for understanding the mechanisms of genome evolution in eukaryotes. Previous comparisons between eukaryotic genomes have revealed considerable conservation across species
Autor:
Patrick Abbot, Abin Abraham, Yakov Pichkar, Sarah L. Fong, Ge Zhang, John A. Capra, Antonis Rokas, Louis J. Muglia, Abigail L. LaBella
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Currently, there is no comprehensive framework to evaluate the evolutionary forces acting on genomic regions associated with human complex traits and contextualize the relationship between evolution and molecular function. Here, we develop an approac
Publikováno v:
PLOS Genetics. 18:e1010494
Natural selection shapes the genetic architecture of many human traits. However, the prevalence of different modes of selection on genomic regions associated with variation in traits remains poorly understood. To address this, we developed an efficie