Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Abigail L Sedlacek"'
Autor:
David O. Osei-Hwedieh, Abigail L. Sedlacek, Luis Mena Hernandez, Archibald Agyekum Yamoah, Swati G. Iyer, Kurt R. Weiss, Robert J. Binder
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
T cells recognize tumor-derived mutated peptides presented on MHC by tumors. The recognition of these neo-epitopes leads to rejection of tumors, an event that is critical for successful cancer immunosurveillance. Determination of tumor-rejecting neo-
Externí odkaz:
https://doaj.org/article/d8f0223374d04824b7fc12598b9767b9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The release of Heat Shock Proteins (HSPs) from aberrant cells can initiate immune responses following engagement of the HSPs with antigen presenting cells (APCs). This is an important mechanism for cancer immunosurveillance and can also be m
Externí odkaz:
https://doaj.org/article/97d4f75192d24757a9d884d4ad3eb92d
Autor:
Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins, Robert J. Binder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasm
Externí odkaz:
https://doaj.org/article/cf78ebbf481d47ad9ecf5de60d0357a8
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
The release of Heat Shock Proteins (HSPs) from aberrant cells can initiate immune responses following engagement of the HSPs with antigen presenting cells (APCs). This is an important mechanism for cancer immunosurveillance and can also be modeled by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681aff4b23fa6a8646591204a47b21b9
http://europepmc.org/articles/PMC8352880
http://europepmc.org/articles/PMC8352880
Autor:
Abigail L Sedlacek, David Osei-Hwedieh, Archibald Agyekum-Yamoah, Luis Mena, Swati Iyer, Kurt Weiss, Robert J Binder
Publikováno v:
The Journal of Immunology. 208:179.12-179.12
T cells recognize tumor neoantigens (TNag) in the context of MHC and eliminate cells which express these antigens, leaving those lacking immunodominant epitopes. Central to investigating tumor immunoediting is the ability to define immunogenic TNag.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95ce8529fce6cdc4464b3a2edf02e3a8
https://doi.org/10.4049/jimmunol.208.supp.179.12
https://doi.org/10.4049/jimmunol.208.supp.179.12
Autor:
Tatiana Shcheglova, Yu Jerry Zhou, Ion I. Mandoiu, Robert J. Binder, Theodore P Younker, Lisa Borghesi, Abigail L. Sedlacek
Publikováno v:
JCI Insight. 4
The immune system detects aberrant, premalignant cells and eliminates them before the development of cancer. Immune cells, including T cells, have been shown to be critical components in eradicating these aberrant cells, and when absent in the host,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96b8d1c2d9a9555091e7116d0b05599
https://doi.org/10.1172/jci.insight.127239
https://doi.org/10.1172/jci.insight.127239
Autor:
Abigail L Sedlacek, Robert J Binder
Publikováno v:
The Journal of Immunology. 206:64.19-64.19
Heat shock protein (HSP)-mediated immune responses encompass both antigen-specific pro-inflammatory responses as well as non-antigen specific regulatory responses. The type of immune response primed depends on antigen presenting cell engaged by the H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3106f8080f60e1725aca9ebae27ade41
https://doi.org/10.4049/jimmunol.206.supp.64.19
https://doi.org/10.4049/jimmunol.206.supp.64.19
Publikováno v:
The Journal of Immunology. 204:166.21-166.21
Immunization with Heat shock proteins (HSPs) elicits a spectrum of immune responses including non-antigen specific immunoregulatory responses and proinflammatory antigen specific responses. While some of the aspects of these mechanisms have been dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8114f5105489c907098050c691d9ba2
https://doi.org/10.4049/jimmunol.204.supp.166.21
https://doi.org/10.4049/jimmunol.204.supp.166.21
Autor:
Yifei Wang, Melanie J. Scott, Haiyan Xu, Robert J. Binder, Sudesh Pawaria, Abigail L. Sedlacek
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(8)
Several heat shock proteins (HSPs) prime immune responses, which are, in part, a result of activation of APCs. APCs respond to these immunogenic HSPs by upregulating costimulatory molecules and secreting cytokines, including IL-1β. These HSP-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0953f0c05a1b6edc2e8ff5918c4b07
https://pubmed.ncbi.nlm.nih.gov/30209191
https://pubmed.ncbi.nlm.nih.gov/30209191
Autor:
Robert J. Binder, Abigail L. Sedlacek, Lauren B. Kinner-Bibeau, Simon C. Watkins, Michelle N. Messmer
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Immune responses primed by endogenous heat shock proteins, specifically gp96, can be varied, and mechanisms controlling these responses have not been defined. Immunization with low doses of gp96 primes T helper type 1 (Th1) immune responses, whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca3c5a557bc14b6b28101fa90558ff8
https://doi.org/10.1038/ncomms15648
https://doi.org/10.1038/ncomms15648