Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies

Autor: Abigail Harland, Xia Liu, Mattia Ghirardello, M. Carmen Galan, Claire M. Perks, Kathreena M. Kurian

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Glioma stem-like cells (GSCs) were first described as a population which may in part be resistant to traditional chemotherapeutic therapies and responsible for tumour regrowth. Knowledge of the underlying metabolic complexity governing GSC growth and

Externí odkaz: https://doaj.org/article/343bfe4cdb0d40628831d705a914bc96

The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity

Autor: Deborah K. Shoemark, Sarah Ratcliffe, Anna Meletiou, Matthew P. Crump, Abigail Harland, J. L. Ross Anderson, Christopher Williams, Paul Curnow, Christopher J. Arthur, Olivia Wilson, Virginie Dufour, Chiratchaya Vamasiri, Christophe J. Lalaurie, Richard B. Sessions

Publikováno v: Lalaurie, C J, Dufour, V, Meletiou, A, Ratcliffe, S, Harland, A, Wilson, O, Vamasiri, C, Shoemark, D K, Williams, C, Arthur, C J, Sessions, R B, Crump, M P, Anderson, J L R & Curnow, P 2018, ' The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity ', Scientific Reports, vol. 8, 14564 . https://doi.org/10.1038/s41598-018-31964-8
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

The de novo design of integral membrane proteins remains a major challenge in protein chemistry. Here, we describe the bottom-up design of a genetically-encoded synthetic membrane protein comprising only four amino acids (L, S, G and W) in the transm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4018a37067562731d77462da3bf8b23
https://hdl.handle.net/1983/a6edeb98-412e-420e-8e74-766d7e88da99