Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin

Autor: K. Ravi Acharya, Clifford C. Shone, Mareike G. Posner, Abigail H. Davies, Joanna McGlashan, April K. Roberts

Publikováno v: Davies, A H, McGlashan, J, Posner, M G, Roberts, A K, Shone, C C & Acharya, K R 2016, ' Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin ', Biochemistry and Biophysics Reports, vol. 8, pp. 55-61 . https://doi.org/10.1016/j.bbrep.2016.08.011
Biochemistry and Biophysics Reports

Clostridium difficile binary toxin (CDT) is an ADP-ribosyltransferase which is linked to enhanced pathogenesis of C. difficile strains. CDT has dual function: domain a (CDTa) catalyses the ADP-ribosylation of actin (enzymatic component), whereas doma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474adf64a5b77c2cccf228000955c8cc
https://purehost.bath.ac.uk/ws/files/147587906/Published_Version.pdf

Molecular features of the sortase enzyme family

Autor: April K. Roberts, Clifford C. Shone, Christopher J. Chambers, William J. Bradshaw, K. Ravi Acharya, Abigail H. Davies

Publikováno v: The FEBS journal. 282(11)

Bacteria possess complex and varying cell walls with many surface exposed proteins. Sortases are responsible for the covalent attachment of specific proteins to the peptidoglycan of the cell wall of Gram-positive bacteria. Sortase A of Staphylococcus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49af9f210c5bd26ae04cf94e784ce59
https://pubmed.ncbi.nlm.nih.gov/25845800